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UniProtKB/Swiss-Prot entry P31822

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name POL_FIVT2
Primary accession number P31822
Secondary accession numbers None
Integrated into Swiss-Prot on July 1, 1993
Sequence was last modified on July 1, 1993 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 80)
Name and origin of the protein
Protein name Pol polyprotein
Synonyms None
Contains Protease
     (EC 3.4.23.-)
     (Retropepsin)
Reverse transcriptase/ribonuclease H
     (RT)
     (EC 2.7.7.49)
     (EC 3.1.26.4)
Deoxyuridine 5'-triphosphate nucleotidohydrolase
     (dUTPase)
     (EC 3.6.1.23)
Integrase
     (IN)
Gene name
Name: pol
From
Feline immunodeficiency virus (isolate TM2) (FIV) [TaxID: 31676] 
Taxonomy Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Feline lentivirus group.
Virus host Felidae (cat family) [TaxID: 9681]
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=1649349 [NCBI, ExPASy, EBI, Israel, Japan]
Kiyomasu T., Miyazawa T., Furuya T., Shibata R., Sakai H., Sakuragi J.I., Fukasawa M., Maki N., Hasegawa A., Mikami T., Adachi A.;
"Identification of feline immunodeficiency virus rev gene activity.";
J. Virol. 65:4539-4542(1991).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC RNA].
DOI=10.1007/BF01317136; PubMed=1312825 [NCBI, ExPASy, EBI, Israel, Japan]
Maki N., Miyazawa T., Fukasawa M., Hasegawa A., Hayami M., Miki K., Mikami T.;
"Molecular characterization and heterogeneity of feline immunodeficiency virus isolates.";
Arch. Virol. 123:29-45(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M59418; AAA43071.1; -; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B45557; B45557.
3D structure databases
HSSP P16088; 4FIV. [HSSP ENTRY / PDB]
SMR P31822; 41-153, 710-843.
ModBase P31822.
Protein family/group databases
MEROPS A02.007; -.
Ontologies
GO
GO:0004190; Molecular function: aspartic-type endopeptidase activity (inferred from electronic annotation from InterPro).
GO:0003677; Molecular function: DNA binding (inferred from electronic annotation from InterPro).
GO:0004170; Molecular function: dUTP diphosphatase activity (inferred from electronic annotation from EC).
GO:0008907; Molecular function: integrase activity (inferred from electronic annotation from InterPro).
GO:0004523; Molecular function: ribonuclease H activity (inferred from electronic annotation from InterPro).
GO:0003723; Molecular function: RNA binding (inferred from electronic annotation from InterPro).
GO:0003964; Molecular function: RNA-directed DNA polymerase activity (inferred from electronic annotation from InterPro).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0015074; Biological process: DNA integration (inferred from electronic annotation from InterPro).
GO:0006310; Biological process: DNA recombination (inferred from electronic annotation from UniProtKB-KW).
GO:0046080; Biological process: dUTP metabolic process (inferred from electronic annotation from InterPro).
GO:0006508; Biological process: proteolysis (inferred from electronic annotation from InterPro).
GO:0006278; Biological process: RNA-dependent DNA replication (inferred from electronic annotation from InterPro).
GO:0032196; Biological process: transposition (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR008180; DeoxyUTPase.
IPR000477; DNA_pol_RVTase.
IPR001037; Integrase_C_retrovir.
IPR001584; Integrase_cat-core.
IPR003308; Integrase_Zn-bd_dom_N.
IPR001969; Pept_Asp_AS.
IPR009007; Pept_Aspartc_cat.
IPR001995; Peptidase_A2_cat.
IPR002156; RNase_H.
IPR010659; RVT_connect.
IPR010661; RVT_thumb.
Graphical view of domain structure.
Gene3D G3DSA:2.30.30.10; Integrase_C; 1.
G3DSA:2.40.70.10; Pept_Aspartc_cat; 1.
Pfam PF00692; dUTPase; 1.
PF00552; Integrase; 1.
PF02022; Integrase_Zn; 1.
PF00075; RnaseH; 1.
PF00665; rve; 1.
PF00077; RVP; 1.
PF00078; RVT_1; 1.
PF06815; RVT_connect; 1.
PF06817; RVT_thumb; 1.
Pfam graphical view of domain structure.
ProDom PD004900; dCTP_deaminase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS50175; ASP_PROT_RETROV; 1.
PS00141; ASP_PROTEASE; 1.
PS50994; INTEGRASE; 1.
PS51027; INTEGRASE_DBD; 1.
PS50879; RNASE_H; 1.
PS50878; RT_POL; 1.
PS50876; ZF_INTEGRASE; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P31822.
ProtoNet P31822.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Aspartyl protease; DNA integration; DNA recombination; Endonuclease; Hydrolase; Metal-binding; Multifunctional enzyme; Nuclease; Nucleotide metabolism; Nucleotidyltransferase; Protease; RNA-directed DNA polymerase; Transferase; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   38    153  116     Protease (By similarity). PRO_0000038849
CHAIN   154    709  556     Reverse transcriptase/ribonuclease H (By similarity). PRO_0000038850
CHAIN   710    843  134     Deoxyuridine 5'-triphosphate nucleotidohydrolase (By similarity). PRO_0000038851
CHAIN   844   1124  281     Integrase (By similarity). PRO_0000038852
DOMAIN   62    143  82     Peptidase A2. 
DOMAIN   199    388  190     Reverse transcriptase. 
DOMAIN   591    711  121     RNase H. 
DOMAIN   899   1049  151     Integrase catalytic. 
ZN_FING   848    889  42     Integrase-type. 
DNA_BIND   1067   1115  49     Integrase-type. 
ACT_SITE   67     67        For protease activity (By similarity). 
Sequence information
Length: 1124 AA [This is the length of the unprocessed precursor] Molecular weight: 128101 Da [This is the MW of the unprocessed precursor] CRC64: F287FE90FC978296 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
ENLGKREGGA SCSPSKPSAA NSTICTSNGG ETIRFINYNT IGTTTTLERR PEIQIFVNGH 

        70         80         90        100        110        120 
PIKFLLDTGA DITILNRKDF QIGNSIENGK QNMIGVGGGK RGTNYINVHL EIRDENYRMQ 

       130        140        150        160        170        180 
CIFGNVCVLE DNSLIQPLLG RDNMIKFNIR LVMAQISEKI PIVKVRMKDP TQGPQVKQWP 

       190        200        210        220        230        240 
LSNEKIEALT DIVERLESEG KVKRADPNNP WNTPVFAIKK KSGKWRMLID FRVLNKLTDK 

       250        260        270        280        290        300 
GAEVQLGLPH PAGLQMKKQV TVLDIGDAYF TIPLDPDYAP YTAFTLPRKN NAGPGRRYVW 

       310        320        330        340        350        360 
CSLPQGWVLS PLIYQSTLNN ILQPFIKQNS ELDIYQYMDD IYIGSNLNKK EHKQKVEELR 

       370        380        390        400        410        420 
KLLLWWGFET PEDKLQEEPP YKWMGYELHP LTWSIQQKQL EIPERPTLNE LQKLAGKINW 

       430        440        450        460        470        480 
ASQTIPDLSI KELTNMMRGD QKLDSIREWT VEAKREVQKA KEAIETQAQL NYYDPNRGLY 

       490        500        510        520        530        540 
AKLSLVGPHQ ICYQVYQKNP EHILWYGKIN RQKKKAENTC DIALRACYKI REESIIRIGK 

       550        560        570        580        590        600 
EPVYEIPASR EAWESNLIRS PYLKAPPPEV EFIHAALSIK RALSMIQDAP IIGAETWYID 

       610        620        630        640        650        660 
GSRKQGKAAR AAYWTNTGKW QIMEIEGSNQ KAEVQALLLA LKAGSEEMNI ITDSQYILNI 

       670        680        690        700        710        720 
LNQQPDLMEG LWQEVLEQME KKIAIFIDWV PGHKGIPGNE EVDKLCQTMM IIEGEGILEK 

       730        740        750        760        770        780 
RSEDAGYDLL AAAQETHFLP GEVRIVPTKT RIMLPKGHWG LIMGKSSIGS KGVDVLGGVI 

       790        800        810        820        830        840 
DEGYRGELGV IMINLTKKSI TILEKQKIAQ LIILPCRHEG LQQGEIQMNS ERGEKGFGSA 

       850        860        870        880        890        900 
GVFSSWVDRI EEAELNHEKF HSDPQYLRTE FNLPRIVAEE IKRKCPLCRI RGEQVGGQLK 

       910        920        930        940        950        960 
IRPGIWQMDC THFNGKIIIV AVHVESGFLW AQIIPQETAD CTVKALLQLI CAHNVTELQT 

       970        980        990       1000       1010       1020 
DNGPNFKNQK MEGLLNYMGI KHKLGIPGNP QSQALVENAN NTLKVWIQKF LPETTSLDNA 

      1030       1040       1050       1060       1070       1080 
LALALHCLNF KQRGRLGRMA PYELYIQQES LRIQDYFSAI PQKLMMQWLY YKDQKDKKWK 

      1090       1100       1110       1120 
GPMRVEYWGQ GSVLLKDEEK GIFLVPRRHI RRVPEPCTLP EGDE
P31822 in FASTA format

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View entry in raw text format (no links)
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