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UniProtKB/Swiss-Prot entry P31792

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name POL_FENV1
Primary accession number P31792
Secondary accession number Q28415
Integrated into Swiss-Prot on July 1, 1993
Sequence was last modified on July 1, 1993 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 58)
Name and origin of the protein
Protein name Pol polyprotein [Fragment]
Synonyms None
Contains Reverse transcriptase/ribonuclease H
     (RT)
     (EC 2.7.7.49)
     (EC 2.7.7.7)
     (EC 3.1.26.4)
Integrase
     (IN)
Gene name
Name: pol
From
Feline endogenous virus ECE1 [TaxID: 11766] 
Taxonomy Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Gammaretrovirus; unclassified Gammaretrovirus.
Virus host Felidae (cat family) [TaxID: 9681]
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Moehring R., Drescher B., Riedel H., Bauer D., Rohde K., Beyer W., Rosenthal S.;
"The exogenous RD-114 and the related endogenous proviral element ECE1 of domestic cat differ in their env genes.";
Submitted (FEB-1990) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X51929; CAB38566.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S12813; GNMVCE.
3D structure databases
HSSP P03355; 1MML. [HSSP ENTRY / PDB]
SMR P31792; 1-449.
ModBase P31792.
Ontologies
GO
GO:0003677; Molecular function: DNA binding (inferred from electronic annotation from InterPro).
GO:0003887; Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from EC).
GO:0004523; Molecular function: ribonuclease H activity (inferred from electronic annotation from InterPro).
GO:0003723; Molecular function: RNA binding (inferred from electronic annotation from InterPro).
GO:0003964; Molecular function: RNA-directed DNA polymerase activity (inferred from electronic annotation from InterPro).
GO:0015074; Biological process: DNA integration (inferred from electronic annotation from InterPro).
GO:0006310; Biological process: DNA recombination (inferred from electronic annotation from UniProtKB-KW).
GO:0006278; Biological process: RNA-dependent DNA replication (inferred from electronic annotation from InterPro).
GO:0032196; Biological process: transposition (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000477; DNA_pol_RVTase.
IPR001584; Integrase_cat-core.
IPR002156; RNase_H.
Graphical view of domain structure.
Pfam PF00075; RnaseH; 1.
PF00665; rve; 1.
PF00078; RVT_1; 1.
Pfam graphical view of domain structure.
PROSITE PS50994; INTEGRASE; 1.
PS50879; RNASE_H; 1.
PS50878; RT_POL; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P31792.
ProtoNet P31792.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
DNA integration; DNA recombination; Endonuclease; Hydrolase; Multifunctional enzyme; Nuclease; Nucleotidyltransferase; RNA-directed DNA polymerase; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   <1    647  >647     Reverse transcriptase/ribonuclease H. PRO_0000040980
CHAIN   648   1046  399     Integrase. PRO_0000040981
DOMAIN   55    248  194     Reverse transcriptase. 
DOMAIN   491    637  147     RNase H. 
DOMAIN   757    915  159     Integrase catalytic. 
NON_TER   1      1         
Sequence information
Length: 1046 AA [This is the length of the partial sequence of the unprocessed precursor] Molecular weight: 117101 Da [This is the MW of the partial sequence of the unprocessed precursor] CRC64: 84556FC1BF29E4A9 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
LQDFPQAWAE TGGLGRAKCQ VPIIIDLKPT AMPVSIRQYP MSKEAHMGIQ PHITRFLELG 

        70         80         90        100        110        120 
VLRPCRSPWN TPLLPVKKPG TRDYRPVQDL REVNKRTMDI HPTVPNPYNL LSTLSPDRTW 

       130        140        150        160        170        180 
YTVLDLKDAF FCLPLAPQSQ ELFAFEWRDP ERGISGQLTW TRLPQGFKNS PTLFDEALHR 

       190        200        210        220        230        240 
DLTDFRTQHP EVTLLQYVDD LLLAAPTKEA CIRGTKHLLR ELGDKGYRAS AKKAQICQTK 

       250        260        270        280        290        300 
VTYLGYILSE GKRWLTPGRI ETVAHIPPPQ NPREVREFLG TAGFCRLWIP GFAELAAPLY 

       310        320        330        340        350        360 
ALTKESAPFT WQEKHQSAFE ALKEALLSAP ALGLPDTSKP FTLFIDEKQG IAKGVLTQKL 

       370        380        390        400        410        420 
GPWKRPVAYL SKKLDPVAAG WPPCLRIMAA TAMLVKDSAK LTLGQPLTVI TPHALEAIVR 

       430        440        450        460        470        480 
QTPDRWITNA RLTHYQALLL DTDRIQFGPP VTLNPATLLP APEDQQSAHD CRQVLAETHG 

       490        500        510        520        530        540 
TREDLKDQEL PDADHSWYTD GSSYIDSGTR RAGAAVVDGH HIIWAQSLPP GTSAQKAELI 

       550        560        570        580        590        600 
ALTKALELSE GKKANIYTDS RYAFATAHTH GSIYERRGLL TSEGKEIKNK AEIIALLKAL 

       610        620        630        640        650        660 
FLPRKVAIIH CPGHQKGQDP IATGNRQADQ VARQVAVAET LTLTTKLEET NLTTNKYAYT 

       670        680        690        700        710        720 
PEDQEEAKAI GAILNQDTKD WEKEGKIVLP RKEALAMIQQ MHAWTHLSNQ KLKLLIEKTD 

       730        740        750        760        770        780 
FLIPKAGTLI EQVTSACKVC QQVNAGATRV PEGKRTRGNR PGVYWEIDFT EVKPHYAGYK 

       790        800        810        820        830        840 
YLLVFVDTFS GWVEAYPTRQ ETAHMVAKKI LEEIFPRFGL PKVIGSDNGP AFVSQVSQGL 

       850        860        870        880        890        900 
ARTLGINWKL HCAYRPQSSG QVERMNRTIK ETLTKLTLET GLKDWRRLLS LALLRARNTP 

       910        920        930        940        950        960 
NRFGLTPYEI LYGGPPPLST LLNSFSPSDP KTDLQARLKG LQAVQAQIWT PLAELYRPGH 

       970        980        990       1000       1010       1020 
PQTSYPFQVG DSVYVRWHRS QGLEPRWKGP YIVLLTTPTA IKVDGIAAWI HASHAKAAPK 

      1030       1040 
TPGPETPKTW KLHRSENPLK IRLSRV
P31792 in FASTA format

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