NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=RM 7004 / Serotype B;
PubMed=1282642 [NCBI, ExPASy, EBI, Israel, Japan]
Maskell D.J., Szabo M.J., Deadman M.E., Moxon E.R.;
"The gal locus from Haemophilus influenzae: cloning, sequencing and the use of gal mutants to study lipopolysaccharide.";
Mol. Microbiol. 6:3051-3063(1992).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
PubMed=7542800 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.";
Science 269:496-512(1995).

Comments

CATALYTIC ACTIVITY: ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate.
PATHWAY: Carbohydrate metabolism; galactose metabolism .
SUBCELLULAR LOCATION: Cytoplasm (Potential).
SIMILARITY: Belongs to the GHMP kinase family. GalK subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X65934; CAA46731.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
L42023; AAC22478.1; ALT_INIT; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

D64096; D64096.

RefSeq

NP_438979.2; -.

3D structure databases

ModBase

P31767.

Enzyme and pathway databases

BioCyc

HINF71421:HI_0819-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0004335;	Molecular function: galactokinase activity (inferred from electronic annotation from HAMAP).
GO:0046835;	Biological process: carbohydrate phosphorylation (inferred from electronic annotation from InterPro).
GO:0006012;	Biological process: galactose metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00246; -; 1.
PBIL [Tree]

InterPro

IPR000705; Galactokinase.
IPR006204; GHMP_kinase.
IPR013750; GHMP_kinase_C.
IPR006203; GHMP_knse_ATP_bd_CS.
IPR006206; Mev_galkinase.
IPR014721; Ribosomal_S5_D2-type_fold.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.230.10; Ribosomal_S5_D2-type_fold; 1.

Pfam

PF08544; GHMP_kinases_C; 1.
PF00288; GHMP_kinases_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000530; Galactokinase; 1.

PRINTS

PR00473; GALCTOKINASE.
PR00959; MEVGALKINASE.

TIGRFAMs

TIGR00131; gal_kin; 1.

PROSITE

PS00106; GALACTOKINASE; 1.
PS00627; GHMP_KINASES_ATP; 1.

Genome annotation databases

950587; -.

L42023_GR; HI0819.

hin:HI0819; -.

fig|71421.1.peg.787; -.

TIGR

HI0819; -.

Phylogenomic databases

HOGENOM

P31767; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Carbohydrate metabolism; Complete proteome; Cytoplasm; Galactose metabolism; Kinase; Nucleotide-binding; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 384`	`384`	`Galactokinase.`	`PRO_0000184612`
`NP_BIND`	`121 131`	`11`	`ATP (Potential).`
`VARIANT`	`107 107`	`1`	`D -> H (in strain: RM 7004).`
`VARIANT`	`145 145`	`1`	`D -> N (in strain: RM 7004).`
`VARIANT`	`321 321`	`1`	`A -> V (in strain: RM 7004).`
`VARIANT`	`331 331`	`1`	`A -> T (in strain: RM 7004).`
`VARIANT`	`353 353`	`1`	`S -> A (in strain: RM 7004).`

Sequence information

Length: 384 AA [This is the length of the unprocessed precursor]

Molecular weight: 42132 Da [This is the MW of the unprocessed precursor]

CRC64: B28D552832858D34 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTPIQNAQQI FNRQHKNLPE ITVYAPGRVN IIGEHTDYND GFVMPCAINF GTAVSGTKRD 

        70         80         90        100        110        120 
DHIWNVYAAD LDETDEFSLN VEIPKSEHKW ANYVRGVVKF IQERYPDFQQ GANLVISGNV 

       130        140        150        160        170        180 
PLSSGLSSSA ALEVAVGKFC QQLGDLPLSH TDIALNGQKA ENQFVGANCG NMDQLISALG 

       190        200        210        220        230        240 
QENHLLMIDC RSLETTPTPV PQDVAVIIVN SNVPHDLVTG EYNTRRQQCE EAAKFFGVKA 

       250        260        270        280        290        300 
LRDVSVEQFQ KREAELTALS PLAAKRARHV VTENQRVLDA VEALKNNDLT CLGKLMEASH 

       310        320        330        340        350        360 
DSMRDDFEIT VPQIDYLVEL AQLVIGKSGG ARMTGGGFGG CIVALAPHDK VDSVRKIIAD 

       370        380 
NYEKTTGLKE TFYVCTASQG VRVI

P31767 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools