NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=RM 7004 / Serotype B;
PubMed=1282642 [NCBI, ExPASy, EBI, Israel, Japan]
Maskell D.J., Szabo M.J., Deadman M.E., Moxon E.R.;
"The gal locus from Haemophilus influenzae: cloning, sequencing and the use of gal mutants to study lipopolysaccharide.";
Mol. Microbiol. 6:3051-3063(1992).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
PubMed=7542800 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.";
Science 269:496-512(1995).

Comments

CATALYTIC ACTIVITY: UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose.
COFACTOR: Binds 1 iron ion per subunit (By similarity).
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
PATHWAY: Carbohydrate metabolism; galactose metabolism .
SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X65934; CAA46730.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
L42023; AAC22479.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

E64096; E64096.

RefSeq

NP_438980.1; -.

3D structure databases

HSSP

P09148; 1HXQ. [HSSP ENTRY / PDB]

ModBase

P31764.

Enzyme and pathway databases

BioCyc

HINF71421:HI_0820-MON; -.

Ontologies

GO:0005506;	Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008108;	Molecular function: UDP-glucose:hexose-1-phosphate uridylyltransferase activity (inferred from electronic annotation from InterPro).
GO:0008270;	Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006012;	Biological process: galactose metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR001937; GalP_UDPtransf1.
IPR005850; GalP_Utransf_C.
IPR005849; GalP_Utransf_N.
IPR011151; His_triad_motif.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.428.10; His_triad_motif; 2.

PANTHER

PTHR11943; GalP_UDPtransf1; 1.

Pfam

PF02744; GalP_UDP_tr_C; 1.
PF01087; GalP_UDP_transf; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000808; GalT; 1.

ProDom

PD005051; GalP_Utransf; 2.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR00209; galT_1; 1.

PROSITE

PS00117; GAL_P_UDP_TRANSF_I; 1.

Genome annotation databases

950798; -.

L42023_GR; HI0820.

hin:HI0820; -.

fig|71421.1.peg.788; -.

TIGR

HI0820; -.

Phylogenomic databases

HOGENOM

P31764; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Carbohydrate metabolism; Complete proteome; Galactose metabolism; Iron; Metal-binding; Nucleotidyltransferase; Transferase; Zinc.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 349`	`349`	`Galactose-1-phosphate uridylyltransferase.`	`PRO_0000169895`
`ACT_SITE`	`167 167`		`Tele-UMP-histidine intermediate (By similarity).`
`METAL`	`53 53`		`Zinc (By similarity).`
`METAL`	`56 56`		`Zinc (By similarity).`
`METAL`	`116 116`		`Zinc (By similarity).`
`METAL`	`165 165`		`Zinc (By similarity).`
`METAL`	`183 183`		`Iron (By similarity).`
`METAL`	`282 282`		`Iron (By similarity).`
`METAL`	`297 297`		`Iron (By similarity).`
`METAL`	`299 299`		`Iron (By similarity).`
`VARIANT`	`221 221`	`1`	`I -> V (in strain: RM 7004).`
`VARIANT`	`229 229`	`1`	`I -> V (in strain: RM 7004).`
`VARIANT`	`334 334`	`1`	`E -> D (in strain: RM 7004).`

Sequence information

Length: 349 AA [This is the length of the unprocessed precursor]

Molecular weight: 40758 Da [This is the MW of the unprocessed precursor]

CRC64: 3BAB24B417E5ECBF [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTALFEPTEH PHRRYNPLID QWVLVSPHRA KRPWQGQQEK VNEEQKPSYD PTCYLCPSNK 

        70         80         90        100        110        120 
RITGELNPDY RKPYVFKNDF SALLEDTPAP EKSSDPLFQS SQARGESRVI CFSPDHSKTL 

       130        140        150        160        170        180 
PLLTALEIEE VIKVWQEQLR ELGAKYQWVQ IFENKGAAMG CSNPHPHGQI WANSFLPNEV 

       190        200        210        220        230        240 
AREDRTQRDY LLKHGSVMLV DYVKRELALK ERIVVETEHW IALVPYWAIW PFETLLLPKT 

       250        260        270        280        290        300 
HVKRLTELSD EQSKDLAVIL KKLTTKYDNL FETSFPYSMG FHAAPFNGED NEHWQLHAHF 

       310        320        330        340 
YPPLLRSATV RKFMVGYEML GENQRDLTAE QAAERLRALS EVHYKERTK

P31764 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools