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UniProtKB/Swiss-Prot entry P31759


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FRZF_MYXXA
Primary accession number P31759
Secondary accession numbers None
Integrated into Swiss-Prot on July 1, 1993
Sequence was last modified on July 1, 1993 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 53)
Name and origin of the protein
Protein name Protein methyltransferase frzF
Synonym EC 2.1.1.80
Gene name
Name: frzF
From
Myxococcus xanthus [TaxID: 34] 
Taxonomy Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales; Cystobacterineae; Myxococcaceae; Myxococcus.
Protein existence 4: Predicted;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=DZF1;
PubMed=2168368 [NCBI, ExPASy, EBI, Israel, Japan]
McCleary W.R., McBride M.J., Zusman D.R.;
"Developmental sensory transduction in Myxococcus xanthus involves methylation and demethylation of FrzCD.";
J. Bacteriol. 172:4877-4887(1990).
Comments
  • FUNCTION: This methyltransferase is one of the proteins required for the normal aggregation of M.xanthus cells during fruiting body formation. It is also a component of a sensory transduction pathway that controls the frequency at which cells reverse their gliding direction. It may methylate frzCD to form gamma-glutamyl methyl ester residues.
  • CATALYTIC ACTIVITY: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.
  • SIMILARITY: Contains 1 cheR-type methyltransferase domain.
  • SIMILARITY: Contains 3 TPR repeats.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M35200; AAA25398.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B36707; XYYZFG.
3D structure databases
HSSP P07801; 1BC5. [HSSP ENTRY / PDB]
ModBase P31759.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0008983; Molecular function: protein-glutamate O-methyltransferase activity (inferred from electronic annotation from EC).
GO:0006935; Biological process: chemotaxis (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000780; CheR_MeTrfase.
IPR001440; TPR-1.
IPR011990; TPR-like_helical.
IPR013105; TPR_2.
IPR013026; TPR_region.
Graphical view of domain structure.
Gene3D G3DSA:1.25.40.10; TPR-like_helical; 1.
Pfam PF01739; CheR; 1.
PF03705; CheR_N; 1.
PF00515; TPR_1; 1.
PF07719; TPR_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00996; CHERMTFRASE.
SMART SM00138; MeTrc; 1.
SM00028; TPR; 3.
SMART graphical view of domain structure.
PROSITE PS50123; CHER; 1.
PS50005; TPR; 3.
PS50293; TPR_REGION; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P31759.
ProtoNet P31759.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Chemotaxis; Methyltransferase; Repeat; S-adenosyl-L-methionine; TPR repeat; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   593  593     Protein methyltransferase frzF. PRO_0000176046
DOMAIN   1   276  276     CheR-type methyltransferase. 
REPEAT   423   456  34     TPR 1. 
REPEAT   457   490  34     TPR 2. 
REPEAT   491   524  34     TPR 3. 
Sequence information
Length: 593 AA [This is the length of the unprocessed precursor] Molecular weight: 64669 Da [This is the MW of the unprocessed precursor] CRC64: B38BA5F481A082B9 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLTASQKVLQ QLAALLLERA GLKITPDGFH SLRLALSARM PVLGLEEPEH YIQRLTGAGG 

        70         80         90        100        110        120 
EEELRSLLPL VTVGHTEFFR DAKQFRALEK SVLPDLVSRS RREMRKVSIW SAGCATGEEP 

       130        140        150        160        170        180 
YSLAMVLAEL GALSLEVDLW ATDLNLAAVE AAKQGRFTSR RAISINQARL TRFFKPVEEG 

       190        200        210        220        230        240 
YEALPALREY IRFDGQNLAV PVFDKVALSS LDLILCRNVI IYFDLPTIRG LMDRFLAALR 

       250        260        270        280        290        300 
PGGLLFLGYS ESLFKVYDRF EMIEVDGAFV YRRPLNDKSM RAPPLRITPY PGEPDVAARR 

       310        320        330        340        350        360 
PVPADAFTAD LRKRMLPEDV PLTTRLPAVS ASSVAAPGSP SVTLPALGAS SSPRSVVPGR 

       370        380        390        400        410        420 
LPAVSPHSPL PAIAARSRVT AELPTVGSVD SARPRITTEL PAVATTPRAP TVEVPAWPTL 

       430        440        450        460        470        480 
LPPAERLAMA VRKMAQGDFS AAIAGVQRLL ADEPSDLDGL LTLGNLFSLT GRIPEAREAF 

       490        500        510        520        530        540 
AQAIQREPLC VEARVFGGVA ALQAGELSEA RSELSKALFL EPTLAIGHYL LAQVHERTQD 

       550        560        570        580        590 
HEAARRSYRN AIAQLRFPQR PLAGHYPEMP DSADAISRAA RYALAALEEQ PLR 

P31759 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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