[1]
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NUCLEOTIDE SEQUENCE [MRNA], AND CATALYTIC ACTIVITY.
PubMed=1851997 [NCBI, ExPASy, EBI, Israel, Japan]
Jones P.F.,
Jakubowicz T.,
Pitossi F.J.,
Maurer F.,
Hemmings B.A.;
"Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.";
Proc. Natl. Acad. Sci. U.S.A. 88:4171-4175(1991).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1007/s001250100577; PubMed=11508278 [NCBI, ExPASy, EBI, Israel, Japan]
Matsubara A.,
Wasson J.C.,
Donelan S.S.,
Welling C.M.,
Glaser B.,
Permutt M.A.;
"Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and their lack of association with Type II diabetes.";
Diabetologia 44:910-913(2001).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Muscle, and Ovary;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] OF 63-480, FUNCTION, CATALYTIC ACTIVITY, AND TISSUE SPECIFICITY.
TISSUE=Foreskin;
PubMed=1718748 [NCBI, ExPASy, EBI, Israel, Japan]
Coffer P.J.,
Woodgett J.R.;
"Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families.";
Eur. J. Biochem. 201:475-481(1991).
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[5]
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ERRATUM, AND SEQUENCE REVISION.
PubMed=1533586 [NCBI, ExPASy, EBI, Israel, Japan]
Coffer P.J.,
Woodgett J.R.;
Eur. J. Biochem. 205:1217-1218(1992).
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[6]
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ENZYME REGULATION, AND PHOSPHORYLATION AT SER-473.
DOI=10.1073/pnas.95.19.11211; PubMed=9736715 [NCBI, ExPASy, EBI, Israel, Japan]
Delcommenne M.,
Tan C.,
Gray V.,
Rue L.,
Woodgett J.R.,
Dedhar S.;
"Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.";
Proc. Natl. Acad. Sci. U.S.A. 95:11211-11216(1998).
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[7]
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MUTAGENESIS OF THR-308 AND SER-473, AND PHOSPHORYLATION AT THR-308 AND SER-473.
PubMed=8978681 [NCBI, ExPASy, EBI, Israel, Japan]
Alessi D.R.,
Andjelkovic M.,
Caudwell F.B.,
Cron P.,
Morrice N.,
Cohen P.,
Hemmings B.A.;
"Mechanism of activation of protein kinase B by insulin and IGF-1.";
EMBO J. 15:6541-6551(1996).
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[8]
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FUNCTION, ENZYME REGULATION, AND PHOSPHORYLATION AT THR-308 BY PDPK1.
PubMed=9512493 [NCBI, ExPASy, EBI, Israel, Japan]
Walker K.S.,
Deak M.,
Paterson A.,
Hudson K.,
Cohen P.,
Alessi D.R.;
"Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.";
Biochem. J. 331:299-308(1998).
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[9]
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INTERACTION WITH MTCP1; TCL1A AND TCL1B.
DOI=10.1016/S1097-2765(00)00039-3; PubMed=10983986 [NCBI, ExPASy, EBI, Israel, Japan]
Laine J.,
Kuenstle G.,
Obata T.,
Sha M.,
Noguchi M.;
"The protooncogene TCL1 is an Akt kinase coactivator.";
Mol. Cell 6:395-407(2000).
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[10]
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INTERACTION WITH TCL1A.
DOI=10.1073/pnas.040557697; PubMed=10716693 [NCBI, ExPASy, EBI, Israel, Japan]
Pekarsky Y.,
Koval A.,
Hallas C.,
Bichi R.,
Tresini M.,
Malstrom S.,
Russo G.,
Tsichlis P.,
Croce C.M.;
"Tcl1 enhances Akt kinase activity and mediates its nuclear translocation.";
Proc. Natl. Acad. Sci. U.S.A. 97:3028-3033(2000).
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[11]
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INTERACTION WITH THEM4, AND SUBCELLULAR LOCATION.
DOI=10.1126/science.1062030; PubMed=11598301 [NCBI, ExPASy, EBI, Israel, Japan]
Maira S.-M.,
Galetic I.,
Brazil D.P.,
Kaech S.,
Ingley E.,
Thelen M.,
Hemmings B.A.;
"Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane.";
Science 294:374-380(2001).
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[12]
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FUNCTION IN PHOSPHORYLATION OF TBC1D4.
DOI=10.1074/jbc.C200198200; PubMed=11994271 [NCBI, ExPASy, EBI, Israel, Japan]
Kane S.,
Sano H.,
Liu S.C.H.,
Asara J.M.,
Lane W.S.,
Garner C.C.,
Lienhard G.E.;
"A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain.";
J. Biol. Chem. 277:22115-22118(2002).
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[13]
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PHOSPHORYLATION AT TYR-474, AND MUTAGENESIS OF TYR-474.
DOI=10.1074/jbc.M203387200; PubMed=12149249 [NCBI, ExPASy, EBI, Israel, Japan]
Conus N.M.,
Hannan K.M.,
Cristiano B.E.,
Hemmings B.A.,
Pearson R.B.;
"Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase.";
J. Biol. Chem. 277:38021-38028(2002).
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[14]
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INTERACTION WITH TCL1A.
DOI=10.1128/MCB.22.5.1513-1525.2002; PubMed=11839817 [NCBI, ExPASy, EBI, Israel, Japan]
Kuenstle G.,
Laine J.,
Pierron G.,
Kagami S.,
Nakajima H.,
Hoh F.,
Roumestand C.,
Stern M.H.,
Noguchi M.;
"Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1.";
Mol. Cell. Biol. 22:1513-1525(2002).
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[15]
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INTERACTION WITH CENTG1, AND PHOSPHORYLATION AT SER-473.
DOI=10.1074/jbc.M312175200; PubMed=14761976 [NCBI, ExPASy, EBI, Israel, Japan]
Ahn J.-Y.,
Rong R.,
Kroll T.G.,
Van Meir E.G.,
Snyder S.H.,
Ye K.;
"PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion.";
J. Biol. Chem. 279:16441-16451(2004).
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[16]
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INTERACTION WITH AKTIP.
DOI=10.1128/MCB.24.4.1493-1504.2004; PubMed=14749367 [NCBI, ExPASy, EBI, Israel, Japan]
Remy I.,
Michnick S.W.;
"Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt.";
Mol. Cell. Biol. 24:1493-1504(2004).
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[17]
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INTERACTION WITH CENTG1.
DOI=10.1073/pnas.0400921101; PubMed=15118108 [NCBI, ExPASy, EBI, Israel, Japan]
Ahn J.-Y.,
Hu Y.,
Kroll T.G.,
Allard P.,
Ye K.;
"PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt.";
Proc. Natl. Acad. Sci. U.S.A. 101:6993-6998(2004).
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[18]
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FUNCTION, CATALYTIC ACTIVITY, AND INTERACTION WITH CCDC88A.
DOI=10.1016/j.devcel.2005.08.001; PubMed=16139227 [NCBI, ExPASy, EBI, Israel, Japan]
Enomoto A.,
Murakami H.,
Asai N.,
Morone N.,
Watanabe T.,
Kawai K.,
Murakumo Y.,
Usukura J.,
Kaibuchi K.,
Takahashi M.;
"Akt/PKB regulates actin organization and cell motility via Girdin/APE.";
Dev. Cell 9:389-402(2005).
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[19]
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PHOSPHORYLATION AT THR-308 AND SER-473.
DOI=10.1126/science.1106148; PubMed=15718470 [NCBI, ExPASy, EBI, Israel, Japan]
Sarbassov D.D.,
Guertin D.A.,
Ali S.M.,
Sabatini D.M.;
"Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.";
Science 307:1098-1101(2005).
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[20]
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PHOSPHORYLATION AT SER-473.
DOI=10.1007/s00401-006-0128-y; PubMed=17013611 [NCBI, ExPASy, EBI, Israel, Japan]
Schick V.,
Majores M.,
Engels G.,
Spitoni S.,
Koch A.,
Elger C.E.,
Simon M.,
Knobbe C.,
Bluemcke I.,
Becker A.J.;
"Activation of Akt independent of PTEN and CTMP tumor-suppressor gene mutations in epilepsy-associated Taylor-type focal cortical dysplasias.";
Acta Neuropathol. 112:715-725(2006).
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[21]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124; SER-126 AND SER-129, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V.,
Blagoev B.,
Gnad F.,
Macek B.,
Kumar C.,
Mortensen P.,
Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
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