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UniProtKB/Swiss-Prot entry P31335

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PUR9_CHICK
Primary accession number P31335
Secondary accession numbers None
Integrated into Swiss-Prot on July 1, 1993
Sequence was last modified on July 1, 1993 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 59)
Name and origin of the protein
Protein name Bifunctional purine biosynthesis protein PURH
Synonyms None
Includes Phosphoribosylaminoimidazolecarboxamide formyltransferase
     (EC 2.1.2.3)
     (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase)
     (AICAR transformylase)
IMP cyclohydrolase
     (EC 3.5.4.10)
     (Inosinicase)
     (IMP synthetase)
     (ATIC)
Gene name
Name: ATIC
Synonyms: PURH
From
Gallus gallus (Chicken) [TaxID: 9031] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
DOI=10.1016/0378-1119(91)90199-L; PubMed=1937050 [NCBI, ExPASy, EBI, Israel, Japan]
Ni L., Guan K., Zalkin H., Dixon J.E.;
"De novo purine nucleotide biosynthesis: cloning, sequencing and expression of a chicken PurH cDNA encoding 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase-IMP cyclohydrolase.";
Gene 106:197-205(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
S64492; AAB20309.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JQ1281; DTCHPH.
RefSeq NP_990509.1; -.
UniGene Gga.4556
3D structure databases
PDB
1G8M; X-ray; 1.75 A; A/B=1-593.[ExPASy / RCSB / EBI]
1M9N; X-ray; 1.93 A; A/B=1-593.[ExPASy / RCSB / EBI]
1OZ0; X-ray; 2.50 A; A/B=1-593.[ExPASy / RCSB / EBI]
1THZ; X-ray; 1.80 A; A/B=1-593.[ExPASy / RCSB / EBI]
2B1G; X-ray; 2.10 A; A/B/C/D=1-593.[ExPASy / RCSB / EBI]
2B1I; X-ray; 2.02 A; A/B=1-593.[ExPASy / RCSB / EBI]
2IU0; X-ray; 2.53 A; A/B=1-593.[ExPASy / RCSB / EBI]
2IU3; X-ray; 2.90 A; A/B=1-593.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1G8M; -.
1M9N; -.
1OZ0; -.
1THZ; -.
2B1G; -.
2B1I; -.
2IU0; -.
2IU3; -.
ModBase P31335.
Ontologies
GO
GO:0003937; Molecular function: IMP cyclohydrolase activity (inferred from electronic annotation from InterPro).
GO:0004643; Molecular function: phosphoribosylaminoimidazolecarboxamide formyltransferase activity (inferred from electronic annotation from InterPro).
GO:0006188; Biological process: IMP biosynthetic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR002695; AICARFT_IMPCHas.
IPR013982; AICARFT_IMPCHas_formly.
IPR011607; MGS.
Graphical view of domain structure.
PANTHER PTHR11692; AICARFT_IMPCHas; 1.
Pfam PF01808; AICARFT_IMPCHas; 1.
PF02142; MGS; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000414; AICARFT_IMPCHas; 1.
SMART SM00798; AICARFT_IMPCHas; 1.
SMART graphical view of domain structure.
TIGRFAMs TIGR00355; purH; 1.
BLOCKS P31335.
ProtoNet P31335.
Genome annotation databases
Ensembl ENSGALG00000003570; Gallus gallus. [Contig view]
GeneID 396091; -.
KEGG gga:396091; -.
Phylogenomic databases
HOGENOM P31335; -.
HOVERGEN P31335; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Hydrolase; Multifunctional enzyme; Purine biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   593  593     Bifunctional purine biosynthesis protein PURH. PRO_0000192155
STRAND   7    13  7      
HELIX   18    27  10      
STRAND   31    34  4      
HELIX   36    44  9      
HELIX   52    56  5      
HELIX   62    64  3      
STRAND   66    68  3      
HELIX   71    78  8      
HELIX   83    91  9      
STRAND   97   103  7      
HELIX   107   111  5      
HELIX   118   122  5      
HELIX   128   138  11      
TURN   139   142  4      
STRAND   144   146  3      
HELIX   149   151  3      
HELIX   152   160  9      
HELIX   169   198  30      
TURN   201   203  3      
STRAND   204   208  5      
STRAND   210   212  3      
STRAND   218   221  4      
STRAND   223   226  4      
STRAND   228   234  7      
HELIX   238   258  21      
STRAND   262   267  6      
STRAND   270   276  7      
HELIX   282   287  6      
TURN   291   293  3      
HELIX   294   296  3      
HELIX   299   309  11      
TURN   312   317  6      
STRAND   318   324  7      
HELIX   328   335  8      
STRAND   339   345  7      
HELIX   349   357  9      
HELIX   358   361  4      
STRAND   364   368  5      
STRAND   376   382  7      
STRAND   385   390  6      
HELIX   398   401  4      
STRAND   406   408  3      
HELIX   413   427  15      
STRAND   434   438  5      
STRAND   441   446  6      
HELIX   452   468  17      
HELIX   472   475  4      
HELIX   485   497  13      
HELIX   504   510  7      
STRAND   513   515  3      
HELIX   522   529  8      
STRAND   535   541  7      
HELIX   547   553  7      
TURN   554   556  3      
STRAND   557   563  7      
HELIX   569   579  11      
STRAND   582   587  6      
Sequence information
Length: 593 AA [This is the length of the unprocessed precursor] Molecular weight: 64415 Da [This is the MW of the unprocessed precursor] CRC64: BD1A34F03D96A136 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAARQQLALL SVSEKAGLVE FARSLNALGL GLIASGGTAT ALRDAGLPVR DVSDLTGFPE 

        70         80         90        100        110        120 
MLGGRVKTLH PAVHAGILAR NIPEDNADMN KQDFSLVRVV VCNLYPFVKT VSSPGVTVPE 

       130        140        150        160        170        180 
AVEKIDIGGV ALLRAAAKNH ARVTVVCDPA DYSSVAKEMA ASKDKDTSVE TRRHLALKAF 

       190        200        210        220        230        240 
THTAQYDAAI SDYFRKEYSK GVSQLPLRYG MNPHQSPAQL YTTRPKLPLT VVNGSPGFIN 

       250        260        270        280        290        300 
LCDALNAWQL VKELKQALGI PAAASFKHVS PAGAAVGIPL SEEEAQVCMV HDLHKTLTPL 

       310        320        330        340        350        360 
ASAYARSRGA DRMSSFGDFI ALSDICDVPT AKIISREVSD GVVAPGYEEE ALKILSKKKN 

       370        380        390        400        410        420 
GGYCVLQMDP NYEPDDNEIR TLYGLQLMQK RNNAVIDRSL FKNIVTKNKT LPESAVRDLI 

       430        440        450        460        470        480 
VASIAVKYTQ SNSVCYAKDG QVIGIGAGQQ SRIHCTRLAG DKANSWWLRH HPRVLSMKFK 

       490        500        510        520        530        540 
AGVKRAEVSN AIDQYVTGTI GEDEDLVKWQ AMFEEVPAQL TEAEKKQWIA KLTAVSLSSD 

       550        560        570        580        590 
AFFPFRDNVD RAKRIGVQFI VAPSGSAADE VVIEACNELG ITLIHTNLRL FHH
P31335 in FASTA format

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