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UniProtKB/Swiss-Prot entry P31318


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ARG56_SCHPO
Primary accession number P31318
Secondary accession numbers None
Integrated into Swiss-Prot on July 1, 1993
Sequence was last modified on October 1, 1996 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 75)
Name and origin of the protein
Protein name Protein arg11, mitochondrial [Precursor]
Synonyms None
Contains N-acetyl-gamma-glutamyl-phosphate reductase
     (EC 1.2.1.38)
     (N-acetyl-glutamate semialdehyde dehydrogenase)
     (NAGSA dehydrogenase)
Acetylglutamate kinase
     (EC 2.7.2.8)
     (NAG kinase)
     (AGK)
     (N-acetyl-L-glutamate 5-phosphotransferase)
Gene name
Name: arg11
ORFNames: SPAC4G9.09c
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 38365 / 975;
DOI=10.1111/j.1432-1033.1992.tb16749.x; PubMed=1313366 [NCBI, ExPASy, EBI, Israel, Japan]
van Huffel C., Dubois E., Messenguy F.;
"Cloning and sequencing of arg3 and arg11 genes of Schizosaccharomyces pombe on a 10-kb DNA fragment. Heterologous expression and mitochondrial targeting of their translation products.";
Eur. J. Biochem. 205:33-43(1992).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X63576; CAA45132.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CU329670; CAA93559.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S22389; S22389.
RefSeq NP_593691.1; -.
3D structure databases
ModBase P31318.
Enzyme and pathway databases
BioCyc SPOM-XXX-01:SPOM-XXX-01-001357-MON; -.
Organism-specific databases
GeneDB_Spombe SPAC4G9.09c; -.
Gene expression databases
ArrayExpress P31318; -.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from direct assay from GeneDB_SPombe).
GO:0003991; Molecular function: acetylglutamate kinase activity (inferred from electronic annotation from InterPro).
GO:0003942; Molecular function: N-acetyl-gamma-glutamyl-phosphate reductase activity (inferred from electronic annotation from InterPro).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0046983; Molecular function: protein dimerization activity (inferred from electronic annotation from InterPro).
GO:0006526; Biological process: arginine biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR004662; AcgluKinase.
IPR000706; AGPR_act_site.
IPR001048; Asp/Glu/Uridylate_kinase.
IPR006855; DUF619.
IPR011241; NAGK_NAGSA.
IPR000534; Semialdehyde_DHase_NAD-bd.
IPR012280; Semialdhyde_DHase_C.
Graphical view of domain structure.
Gene3D G3DSA:3.40.1160.10; Aa_kinase; 1.
Pfam PF00696; AA_kinase; 1.
PF04768; DUF619; 1.
PF01118; Semialdhyde_dh; 1.
PF02774; Semialdhyde_dhC; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036440; ARG5-6; 1.
ProDom PD003765; AGPR_act_site; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00761; argB; 1.
TIGR01850; argC; 1.
PROSITE PS01224; ARGC; 1.
BLOCKS P31318.
ProtoNet P31318.
Genome annotation databases
GeneID 2543391; -.
KEGG spo:SPAC4G9.09c; -.
NMPDR fig|4896.1.peg.3661; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Arginine biosynthesis; Cleavage on pair of basic residues; Complete proteome; Kinase; Mitochondrion; Multifunctional enzyme; NADP; Oxidoreductase; Transferase; Transit peptide.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
TRANSIT   1    59  59     Mitochondrion (Potential). 
CHAIN   60   550  491     Acetylglutamate kinase (Potential). PRO_0000002071
CHAIN   551   885  335     N-acetyl-gamma-glutamyl-phosphate reductase (Potential). PRO_0000002072
ACT_SITE   703   703        By similarity. 
VARIANT   261   261  1     V -> D (in strain: 975). 
VARIANT   345   345  1     G -> P (in strain: 975). 
Sequence information
Length: 885 AA [This is the length of the unprocessed precursor] Molecular weight: 97705 Da [This is the MW of the unprocessed precursor] CRC64: 3AA1A5082431B118 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLIELQQIVK SGLVRNGAKH CTKRSLLCSN ASVIASKRFQ GSFAPGQQQP LNPLAKPIEQ 

        70         80         90        100        110        120 
DRDAIIRILS SIGSRREVEQ YLRYFTSFEA QRFAIIKVGG AIITDELDTL AQSLAFLNHV 

       130        140        150        160        170        180 
GLYPIVVHGA GPQLNKILAS RNVEPEYSDG IRITDAETLS VARKVFLEEN AKLVDALEKL 

       190        200        210        220        230        240 
GTRARPITGG VFQAEYLDKE KYKYVGKIVK VNKAPIEHSI RAGTLPILTS MAETASGQLL 

       250        260        270        280        290        300 
NVNADITAGE LARVLKPLKV VYLNEKGGLI NGETKKKISS IYLDREYDGL MKQPWVKYGT 

       310        320        330        340        350        360 
KLKIKEIKEL LDTLPRTSSV AIISTKDLQK ELFTESGAGT LISRGFVINK HDSLDSIPDA 

       370        380        390        400        410        420 
ALENLIIQKN SLAAPSESLK QFKDTLKDRK LRIYSDSFNE SVAIVDTTDS SLPVLLAFGA 

       430        440        450        460        470        480 
ADNNWLNNVV DSILTTLKAD FPSLLWRLQP SAKNLEWFFS KSEGTLFANN FYYFWYGVKD 

       490        500        510        520        530        540 
LNKISKFIQS DKPFADAIIQ TQSTKPPTAS STTNNPSSSQ INQKRSYSTS SLFSKNKKMN 

       550        560        570        580        590        600 
RSLFLKGGKR FFSAEAQKTQ KPLKAVSSKP AKVVLLGARG YTGKNLIGLI NTHPYLELSH 

       610        620        630        640        650        660 
VSSRELEGTK LPGYTKKEIQ YVNLSTDDVK KLEEEGAVDA WVMALPNGVC KPYVDALTSA 

       670        680        690        700        710        720 
NGKSVIVDLS ADYRFEPSWQ YGLPELNDRE ALRNSKRISN PGCYATGSQV GLTPILSLID 

       730        740        750        760        770        780 
GQPSIFGVSG YSGAGTKPSP KNDLNVLTNN LIPYSLTDHI HEREISYRLK QPVAFIPHVA 

       790        800        810        820        830        840 
QWFQGITLTI NVPLKKSITS RELRNLYQDR YNGEPLIHVQ GDVPLVKDNA HKHHVSVGGF 

       850        860        870        880 
GVHSSGKRAV IVVTIDNLLK GAATQALQNL NLSCGYDEYA GIHLD 

P31318 in FASTA format

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