[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Peripheral blood leukocyte;
DOI=10.1016/0014-5793(95)00393-N; PubMed=7758584 [NCBI, ExPASy, EBI, Israel, Japan]
Suzuki K.,
Nishihata J.,
Arai Y.,
Honma N.,
Yamamoto K.,
Irimura T.,
Toyoshima S.;
"Molecular cloning of a novel actin-binding protein, p57, with a WD repeat and a leucine zipper motif.";
FEBS Lett. 364:283-288(1995).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
Grogan A.,
Keep N.H.,
Reeves E.,
Segal A.W.;
Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Kidney;
Liau G.,
Popa I.,
Argraves K.,
Argraves W.S.;
Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [MRNA].
Kohchi C.,
Inagawa H.,
Makino K.,
Terada H.,
Soma G.;
"A new therapeutic strategy of mycobacterium infection by use of anti-TACO sequence.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[6]
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PROTEIN SEQUENCE OF 2-9; 50-65; 242-252; 433-448 AND 453-460, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, AND MASS SPECTROMETRY.
TISSUE=T-cell;
Bienvenut W.V.,
Kanor S.,
Tissot J.-D.,
Quadroni M.;
Submitted (MAY-2006) to UniProtKB.
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[7]
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PROTEIN SEQUENCE OF 355-374.
TISSUE=Keratinocyte;
DOI=10.1002/elps.11501301199; PubMed=1286667 [NCBI, ExPASy, EBI, Israel, Japan]
Rasmussen H.H.,
van Damme J.,
Puype M.,
Gesser B.,
Celis J.E.,
Vandekerckhove J.;
"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.";
Electrophoresis 13:960-969(1992).
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[8]
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ROLE IN PHAGOSOME TRAFFICKING.
DOI=10.1016/S0092-8674(00)80754-0; PubMed=10338208 [NCBI, ExPASy, EBI, Israel, Japan]
Ferrari G.,
Langen H.,
Naito M.,
Pieters J.;
"A coat protein on phagosomes involved in the intracellular survival of mycobacteria.";
Cell 97:435-447(1999).
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- FUNCTION: May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
- SUBUNIT: Binds actin (By similarity).
- INTERACTION:
O94907:DKK1; NbExp=1; IntAct=EBI-1046676, EBI-742864;
P60604:UBE2G2; NbExp=1; IntAct=EBI-1046676, EBI-1051028;
- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cell cortex (By similarity). Cytoplasmic vesicle, phagosome membrane (By similarity). Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity).
- TISSUE SPECIFICITY: Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.
- SIMILARITY: Belongs to the WD repeat coronin family.
- SIMILARITY: Contains 5 WD repeats.
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