NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Madrid E;
DOI=10.1016/0378-1119(93)90238-X; PubMed=8224887 [NCBI, ExPASy, EBI, Israel, Japan]
Aliabadi Z., Winkler H.H., Wood D.O.;
"Isolation and characterization of the Rickettsia prowazekii gene encoding the flavoprotein subunit of succinate dehydrogenase.";
Gene 133:135-140(1993).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Madrid E;
DOI=10.1038/24094; PubMed=9823893 [NCBI, ExPASy, EBI, Israel, Japan]
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.;
"The genome sequence of Rickettsia prowazekii and the origin of mitochondria.";
Nature 396:133-140(1998).

Comments

CATALYTIC ACTIVITY: Succinate + acceptor = fumarate + reduced acceptor.
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle .
SUBUNIT: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and an hydrophobic anchor protein.
SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).
SIMILARITY: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M88696; AAA16097.1; -; Unassigned_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U02603; AAA18327.1; -; Unassigned_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ235270; CAA14597.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

JN0895; JN0895.

RefSeq

NP_220520.1; -.

3D structure databases

HSSP

P10444; 1NEK. [HSSP ENTRY / PDB]

ModBase

P31038.

Enzyme and pathway databases

BioCyc

RPRO272947:RP128-MON; -.

Family and domain databases

InterPro

IPR003953; FAD_bind2_N.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR003952; FRD_SDH_FAD_BS.
IPR004112; Fum_Rdtase/Succ_DHase_flav_C.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR011281; Succ_DHase_flav_su_fwd.
IPR014006; Succ_Dhase_frdA_Gneg.
Graphical view of domain structure.

Pfam

PF00890; FAD_binding_2; 1.
PF02910; Succ_DH_flav_C; 1.
Pfam graphical view of domain structure.

PRINTS

PR00368; FADPNR.
PR00411; PNDRDTASEI.

TIGRFAMs

TIGR01816; sdhA_forward; 1.
TIGR01812; sdhA_frdA_Gneg; 1.

PROSITE

PS00504; FRD_SDH_FAD_BINDING; 1.

BLOCKS

P31038.

Genome annotation databases

GeneID

883752; -.

GenomeReviews

AJ235269_GR; RP128.

KEGG

rpr:RP128; -.

Phylogenomic databases

HOGENOM

P31038; -.

Genome annotation databases

CMR

P31038; RP128.

Other

ProtoNet

P31038.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell inner membrane; Cell membrane; Complete proteome; Electron transport; FAD; Flavoprotein; Membrane; Oxidoreductase; Transport; Tricarboxylic acid cycle.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 596`	`596`	`Succinate dehydrogenase flavoprotein subunit.`	`PRO_0000158657`
`NP_BIND`	`41 56`	`16`	`FAD (By similarity).`
`ACT_SITE`	`290 290`		`Proton acceptor (By similarity).`
`BINDING`	`246 246`		`Substrate (By similarity).`
`BINDING`	`258 258`		`Substrate (By similarity).`
`BINDING`	`357 357`		`Substrate (By similarity).`
`BINDING`	`402 402`		`Substrate (By similarity).`
`MOD_RES`	`49 49`		`Tele-8alpha-FAD histidine (By similarity).`

Sequence information

Length: 596 AA [This is the length of the unprocessed precursor]

Molecular weight: 65445 Da [This is the MW of the unprocessed precursor]

CRC64: E5CAA5DFE9426EC4 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTKAYNIIHH KFDVVVVGAG GAGLRSAFGM AKEGLNTACI TKIFPTRSHT VAAQGGISAA 

        70         80         90        100        110        120 
LGNMGEDDWR WHMYDTVKGS DWLGDQDAIE YMCKNAPDAI LELEHYGVPF SRTVDGKIYQ 

       130        140        150        160        170        180 
RPFGGMTTEY GKGKAAQRTC AAADRTGHAI LHTLYQQSLK HKVQFFIEYF AIDLLMEDGE 

       190        200        210        220        230        240 
CRGVVAWNLD DGSLHCFRAH NVVLATGGYG RAYFSATSAH TCTGDGGGMV IRAGLPLQDM 

       250        260        270        280        290        300 
EFVQFHPTGI YSAGCLITEG ARGEGGYLVN ANGERFMERY APAAKDLASR DVVSRAMTIE 

       310        320        330        340        350        360 
IREGRGVGEH KDHVFLHLNH LSPEILHRRL PGISETAKIF AGVDVTKDPI PVLPTVHYNM 

       370        380        390        400        410        420 
GGIPTNYQGQ VIIKDGKNHN SIVNGIMAIG EAACVSVHGA NRLGSNSLLD LVVFGRSSAL 

       430        440        450        460        470        480 
KAAELIKPAS PHKPLQKETL EKIINRFDKV RYANGNILVA DLRLKMQRTM QSHVSVFRTQ 

       490        500        510        520        530        540 
KLLDEGVGMI SEIRNRYKDI KINDKSLIWN SDLVEALELD NLLDQALVTV CSAAARKESR 

       550        560        570        580        590 
GAHAREDYPD RNDRDWIKHT LSSIDDSGKV VLDYKPVTLT TLTDAISAIP PVKRVY

P31038 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools