[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM E), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE. STRAIN=Oregon-R; TISSUE=Embryo; DOI=10.1016/0092-8674(81)90009-X; PubMed=1651169 [NCBI, ExPASy, EBI, Israel, Japan] Woods D.F., Bryant P.J.; "The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions."; Cell 66:451-464(1991).
[2]	NUCLEOTIDE SEQUENCE (ISOFORMS B; F; H; I AND S97), FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY. TISSUE=Embryo; PubMed=12657668 [NCBI, ExPASy, EBI, Israel, Japan] Mendoza C., Olguin P., Lafferte G., Thomas U., Ebitsch S., Gundelfinger E.D., Kukuljan M., Sierralta J.; "Novel isoforms of Dlg are fundamental for neuronal development in Drosophila."; J. Neurosci. 23:2093-2101(2003).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=Berkeley; DOI=10.1126/science.287.5461.2185; PubMed=10731132 [NCBI, ExPASy, EBI, Israel, Japan] Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; "The genome sequence of Drosophila melanogaster."; Science 287:2185-2195(2000).
[4]	GENOME REANNOTATION, AND ALTERNATIVE SPLICING. PubMed=12537572 [NCBI, ExPASy, EBI, Israel, Japan] Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."; Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[5]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS F AND I), AND NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 711-970 (ISOFORM G). STRAIN=Berkeley; TISSUE=Embryo, and Head; PubMed=12537569 [NCBI, ExPASy, EBI, Israel, Japan] Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.; "A Drosophila full-length cDNA resource."; Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
[6]	FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY. DOI=10.1126/science.289.5476.113; PubMed=10884224 [NCBI, ExPASy, EBI, Israel, Japan] Bilder D., Li M., Perrimon N.; "Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors."; Science 289:113-116(2000).
[7]	PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496 AND THR-714, AND MASS SPECTROMETRY. TISSUE=Embryo; DOI=10.1021/pr700696a; PubMed=18327897 [NCBI, ExPASy, EBI, Israel, Japan] Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; "Phosphoproteome analysis of Drosophila melanogaster embryos."; J. Proteome Res. 7:1675-1682(2008).

Comments

FUNCTION: During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.
INTERACTION:
Q9W4I9:-; NbExp=1; IntAct=EBI-389374, EBI-109489;
Q9V3G9:EG:BACR37P7.5; NbExp=1; IntAct=EBI-389374, EBI-162998;
Q8IMX7:Miro; NbExp=1; IntAct=EBI-389374, EBI-167586;
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell junction, septate junction. Note=Cytoskeleton- and membrane-associated. Located at the cytoplasmic face of the membrane in the cellular blastoderm and becomes associated with septate junctions which begin to form between epithelial cells at the time of dorsal closure. In adult flies, located at the apical-lateral membrane boundary of epithelial cells.

ALTERNATIVE PRODUCTS: 8 named isoforms [FASTA] produced by alternative splicing.

Name	B
Isoform ID	P31007-2
Note: Contains the N-terminal domain essential for correct neuronal development.
This is the isoform sequence displayed in this entry.

Name	A
Isoform ID	P31007-3
Note: No experimental confirmation available.
Features which should be applied to build the isoform sequence: VSP_011403, VSP_011405, VSP_011410, VSP_011414.

Name	E
Synonyms	Dlg-A, D
Isoform ID	P31007-1
Note: Ref.1 (AAA28468) sequence is in conflict in position: 355:S->D.
Features which should be applied to build the isoform sequence: VSP_011402, VSP_011404, VSP_011410, VSP_011414.

Name	F
Isoform ID	P31007-4
Note: Contains the N-terminal domain essential for correct neuronal development.
Features which should be applied to build the isoform sequence: VSP_011401, VSP_011411, VSP_011412.

Name	G
Isoform ID	P31007-5
Note: No experimental confirmation available.
Features which should be applied to build the isoform sequence: VSP_011402, VSP_011404, VSP_011410, VSP_011413.

Name	H
Isoform ID	P31007-6
Note: Contains the N-terminal domain essential for correct neuronal development.
Features which should be applied to build the isoform sequence: VSP_011406.

Name	I
Synonyms	C
Isoform ID	P31007-7
Note: Contains the N-terminal domain essential for correct neuronal development.
Features which should be applied to build the isoform sequence: VSP_011406, VSP_011408, VSP_011409.

Name	S97
Isoform ID	P31007-8
Note: Contains the N-terminal domain essential for correct neuronal development.
Features which should be applied to build the isoform sequence: VSP_011406, VSP_011407, VSP_011415.

TISSUE SPECIFICITY: During the cellular blastoderm stage, isoform B, isoform F, isoform H, isoform I and isoform S97 expression is localized to the cell borders. From stage 11 onwards, expression is found predominantly in the developing nervous system: axon bundles in the ventral cord and the brain. Stage 14 and 15 embryos exhibit expression in the developing body wall muscle. Expression in neuropil regions of the CNS and at NMJs persists through to larval development. Other isoforms show expression in embryonic epithelial cells. In larvae, expression is seen as a belt around salivary glands, imaginal disks and proventriculus. Expressed in adult reproductive tissues. In epithelia, coexpressed with scrib throughout development.
DEVELOPMENTAL STAGE: Expressed both maternally and zygotically throughout development.
SIMILARITY: Belongs to the MAGUK family.
SIMILARITY: Contains 1 guanylate kinase-like domain.
SIMILARITY: Contains 1 L27 domain.
SIMILARITY: Contains 3 PDZ (DHR) domains.
SIMILARITY: Contains 1 SH3 domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M73529; AAA28468.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY332243; AAQ01226.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014298; AAF48037.2; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014298; AAF48038.2; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014298; AAF48039.2; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014298; AAN09630.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014298; AAS65308.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014298; AAS65309.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014298; AAS65312.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY059433; AAL13339.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY069408; AAL39553.1; ALT_INIT; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY075410; AAL68235.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A39651; A39651.

RefSeq

NP_511120.2; -.
NP_727518.1; -.
NP_727519.1; -.
NP_727520.1; -.
NP_996404.1; -.
NP_996405.1; -.
NP_996406.1; -.

UniGene

Dm.4352

3D structure databases

HSSP

P31016; 1JXO. [HSSP ENTRY / PDB]

ModBase

P31007.

Protein-protein interaction databases

IntAct

P31007; -.

Organism-specific databases

FlyBase

FBgn0001624; dlg1.

Gene expression databases

ArrayExpress

P31007; -.

GermOnline

CG1725; Drosophila melanogaster.

Ontologies

GO:0045179;	Cellular component: apical cortex (inferred from direct assay from FlyBase).
GO:0016323;	Cellular component: basolateral plasma membrane (traceable author statement from FlyBase).
GO:0005856;	Cellular component: cytoskeleton (inferred from electronic annotation from UniProtKB-KW).
GO:0045211;	Cellular component: postsynaptic membrane (inferred from direct assay from FlyBase).
GO:0005918;	Cellular component: septate junction (traceable author statement from FlyBase).
GO:0043195;	Cellular component: terminal button (inferred from direct assay from FlyBase).
GO:0005154;	Molecular function: epidermal growth factor receptor binding (traceable author statement from FlyBase).
GO:0004385;	Molecular function: guanylate kinase activity (traceable author statement from FlyBase).
GO:0004871;	Molecular function: signal transducer activity (inferred from electronic annotation from UniProtKB-KW).
GO:0005198;	Molecular function: structural molecule activity (traceable author statement from FlyBase).
GO:0045167;	Biological process: asymmetric protein localization during cell fate commitment (traceable author statement from FlyBase).
GO:0045175;	Biological process: basal protein localization (inferred from mutant phenotype from FlyBase).
GO:0007417;	Biological process: central nervous system development (inferred from mutant phenotype from FlyBase).
GO:0007010;	Biological process: cytoskeleton organization (non-traceable author statement from FlyBase).
GO:0007391;	Biological process: dorsal closure (traceable author statement from FlyBase).
GO:0051294;	Biological process: establishment of spindle orientation (inferred from mutant phenotype from FlyBase).
GO:0045197;	Biological process: establishment or maintenance of epithelial cell apical/basal polarity (traceable author statement from FlyBase).
GO:0045196;	Biological process: establishment or maintenance of neuroblast polarity (traceable author statement from FlyBase).
GO:0016332;	Biological process: establishment or maintenance of polarity of embryonic epithelium (traceable author statement from FlyBase).
GO:0016334;	Biological process: establishment or maintenance of polarity of follicular epithelium (inferred from genetic interaction from FlyBase).
GO:0016336;	Biological process: establishment or maintenance of polarity of larval imaginal disc epithelium (traceable author statement from FlyBase).
GO:0001738;	Biological process: morphogenesis of a polarized epithelium (traceable author statement from FlyBase).
GO:0008285;	Biological process: negative regulation of cell proliferation (traceable author statement from FlyBase).
GO:0030182;	Biological process: neuron differentiation (inferred from mutant phenotype from FlyBase).
GO:0007422;	Biological process: peripheral nervous system development (inferred from mutant phenotype from FlyBase).
GO:0030710;	Biological process: regulation of border follicle cell delamination (traceable author statement from FlyBase).
GO:0051726;	Biological process: regulation of cell cycle (non-traceable author statement from FlyBase).
GO:0019991;	Biological process: septate junction assembly (traceable author statement from FlyBase).
GO:0007165;	Biological process: signal transduction (inferred from electronic annotation from UniProtKB-KW).
GO:0007268;	Biological process: synaptic transmission (inferred from mutant phenotype from FlyBase).
GO:0045186;	Biological process: zonula adherens assembly (traceable author statement from FlyBase).
QuickGo view.

Family and domain databases

InterPro

IPR008144; Guanylate_kin.
IPR008145; Guanylt/Ca.
IPR004172; L27.
IPR015143; L27_1.
IPR001478; PDZ.
IPR001452; SH3.
Graphical view of domain structure.

Pfam

PF00625; Guanylate_kin; 1.
PF09058; L27_1; 1.
PF00595; PDZ; 3.
PF00018; SH3_1; 1.
Pfam graphical view of domain structure.

PRINTS

PR00452; SH3DOMAIN.

ProDom

PD000066; SH3; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00072; GuKc; 1.
SM00569; L27; 1.
SM00228; PDZ; 3.
SM00326; SH3; 1.
SMART graphical view of domain structure.

PROSITE

PS00856; GUANYLATE_KINASE_1; 1.
PS50052; GUANYLATE_KINASE_2; 1.
PS51022; L27; 1.
PS50106; PDZ; 3.
PS50002; SH3; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

CG1725; Drosophila melanogaster. [Contig view]

GeneID

32083; -.

NMPDR

fig|7227.3.peg.17410; -.

Other

LinkHub

P31007; -.

NextBio

776723; -.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Membrane; Neurogenesis; Phosphoprotein; Repeat; SH3 domain; Transducer.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 970`	`970`	`Disks large 1 tumor suppressor protein.`	`PRO_0000094538`
`DOMAIN`	`4 64`	`61`	`L27.`
`DOMAIN`	`216 303`	`88`	`PDZ 1.`
`DOMAIN`	`330 421`	`92`	`PDZ 2.`
`DOMAIN`	`506 587`	`82`	`PDZ 3.`
`DOMAIN`	`620 690`	`71`	`SH3.`
`DOMAIN`	`780 955`	`176`	`Guanylate kinase-like.`
`MOD_RES`	`496 496`		`Phosphoserine.`
`MOD_RES`	`714 714`		`Phosphothreonine.`
`VAR_SEQ`	`1 37`		`MPVKKQEAHRALELLEDYHARLSEPQDRALRIAIERV -> MTTRKKKRDGGGSGGGFIKKVSSLFNLDSLHKASSTK (in isoform A).`	`VSP_011403`
`VAR_SEQ`	`1 29`		`MPVKKQEAHRALELLEDYHARLSEPQDRA -> MTTRKKKRDGGGSGGGFIKKVSSLFNLDS (in isoform E and isoform G).`	`VSP_011402`
`VAR_SEQ`	`1 7`		`MPVKKQE -> MDSDTDSEREKSSDPNEGLLSSDDKTFHDDDEPAEDSSPA` `DDEEEPEEEECLLPQKKAQIRCDQDQPPLVVLVQPSAEAI` `EVRQEIDDTNPVAVAAKASDMDGDSQLEVMEHQMETVTEP` `DPEPPKCPTSLRDSVRESVECFYSAQDLLEYGHMLSSTSM` `VRTPDVESGYFEKSESDASRDEWEGPSSSSSGAARCRLLS` `GISGLSVSSSSRHSAEGLRMELSRFRTMIETLERESLEKS` `QSELQLKAKSKAKPKPKQRSHVQDAAGESGSEQGSERGFW` `STIFGQAGLAISQDEEERIADIQK (in isoform F).`	`VSP_011401`
`VAR_SEQ`	`30 205`		`Missing (in isoform E and isoform G).`	`VSP_011404`
`VAR_SEQ`	`38 205`		`Missing (in isoform A).`	`VSP_011405`
`VAR_SEQ`	`93 151`		`Missing (in isoform I, isoform H and isoform S97).`	`VSP_011406`
`VAR_SEQ`	`205 205`		`T -> TLHKASSTK (in isoform S97).`	`VSP_011407`
`VAR_SEQ`	`206 267`		`VNGDDSWLYEDIQLERGNSGLGFSIAGGTDNPHIGTDTSI` `YITKLISGGAAAADGRLSINDI -> SQIQIQSLTQTYPNAHQRKRVLVSLHPHQHQHQSQIQHQH` `HYQLRHNNGIQAKMLKRAFEST (in isoform I).`	`VSP_011408`
`VAR_SEQ`	`268 970`		`Missing (in isoform I).`	`VSP_011409`
`VAR_SEQ`	`473 519`		`EPGSRYASTNVLAAVPPGTPRAVSTEDITREPRTITIQKG` `PQGLGFN -> AFMLCYTQDDANAEGGEIIYRVELPDMEQITLIYLENNDA` `DYRKSSI (in isoform F).`	`VSP_011411`
`VAR_SEQ`	`473 473`		`E -> GALNSMGQTVVDSPSIPQAAAAVAAAANASASASVIASNN` `TISNTTVTTVTATATASNSSSKLPPSLGANSSISISNSNS` `NSNSNNINNINSINNNNSSSSSTTATVAAATPTAASAAAA` `AASSPPANSFYNNASMPALPVESNQTNNRSQSPQPRQ (in isoform A, isoform E and isoform G).`	`VSP_011410`
`VAR_SEQ`	`520 970`		`Missing (in isoform F).`	`VSP_011412`
`VAR_SEQ`	`746 746`		`P -> PNGVVSSTSEIDINNVNNNQSNEPQP (in isoform G).`	`VSP_011413`
`VAR_SEQ`	`747 761`		`FMLCYTQDDANAEGA -> NGVVSSTSEIDINNVNNNQSNEPQP (in isoform A and isoform E).`	`VSP_011414`
`VAR_SEQ`	`761 761`		`A -> GEIIYRVELPDMEQITLIYLENNDADYP (in isoform S97).`	`VSP_011415`
`CONFLICT`	`365 365`		`M -> T (in Ref. 1 and 2).`
`CONFLICT`	`369 369`		`A -> R (in Ref. 1 and 2).`

Sequence information

Length: 970 AA [This is the length of the unprocessed precursor]

Molecular weight: 106673 Da [This is the MW of the unprocessed precursor]

CRC64: 544D1E1AD03B0674 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPVKKQEAHR ALELLEDYHA RLSEPQDRAL RIAIERVIRI FKSRLFQALL DIQEFYELTL 

        70         80         90        100        110        120 
LDDSKSIQQK TAETLQIATK WEKDGQAVKI ADFIKSSNLN RNCAYEFNND ASSNQTNQSA 

       130        140        150        160        170        180 
LNQNPIANNV SAQAQAEALS RTFKSELEEI LNQRMRIESD TENAKEPTVE QQQKQQQAQQ 

       190        200        210        220        230        240 
RSSRSPQQQN PQQQQGSKSR SGSQTVNGDD SWLYEDIQLE RGNSGLGFSI AGGTDNPHIG 

       250        260        270        280        290        300 
TDTSIYITKL ISGGAAAADG RLSINDIIVS VNDVSVVDVP HASAVDALKK AGNVVKLHVK 

       310        320        330        340        350        360 
RKRGTATTPA AGSAAGDARD SAASGPKVIE IDLVKGGKGL GFSIAGGIGN QHIPGDNGIY 

       370        380        390        400        410        420 
VTKLMDGGAA QVDGRLSIGD KLIAVRTNGS EKNLENVTHE LAVATLKSIT DKVTLIIGKT 

       430        440        450        460        470        480 
QHLTTSASGG GGGGLSSGQQ LSQSQSQLAT SQSQSQVHQQ QHATPMVNSQ STEPGSRYAS 

       490        500        510        520        530        540 
TNVLAAVPPG TPRAVSTEDI TREPRTITIQ KGPQGLGFNI VGGEDGQGIY VSFILAGGPA 

       550        560        570        580        590        600 
DLGSELKRGD QLLSVNNVNL THATHEEAAQ ALKTSGGVVT LLAQYRPEEY NRFEARIQEL 

       610        620        630        640        650        660 
KQQAALGAGG SGTLLRTTQK RSLYVRALFD YDPNRDDGLP SRGLPFKHGD ILHVTNASDD 

       670        680        690        700        710        720 
EWWQARRVLG DNEDEQIGIV PSKRRWERKM RARDRSVKFQ GHAAANNNLD KQSTLDRKKK 

       730        740        750        760        770        780 
NFTFSRKFPF MKSRDEKNED GSDQEPFMLC YTQDDANAEG ASEENVLSYE AVQRLSINYT 

       790        800        810        820        830        840 
RPVIILGPLK DRINDDLISE YPDKFGSCVP HTTRPKREYE VDGRDYHFVS SREQMERDIQ 

       850        860        870        880        890        900 
NHLFIEAGQY NDNLYGTSVA SVREVAEKGK HCILDVSGNA IKRLQVAQLY PVAVFIKPKS 

       910        920        930        940        950        960 
VDSVMEMNRR MTEEQAKKTY ERAIKMEQEF GEYFTGVVQG DTIEEIYSKV KSMIWSQSGP 

       970 
TIWVPSKESL

P31007 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools