[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Pituitary; DOI=10.1016/0014-5793(96)00976-3; PubMed=8830661 [NCBI, ExPASy, EBI, Israel, Japan] Anouar Y., Jegou S., Alexandre D., Lihrmann I., Conlon J.M., Vaudry H.; "Molecular cloning of frog secretogranin II reveals the occurrence of several highly conserved potential regulatory peptides."; FEBS Lett. 394:295-299(1996).
[2]	PROTEIN SEQUENCE OF 183-215. TISSUE=Brain; DOI=10.1016/0014-5793(91)80754-Q; PubMed=2060624 [NCBI, ExPASy, EBI, Israel, Japan] Vaudry H., Conlon J.M.; "Identification of a peptide arising from the specific post-translation processing of secretogranin II."; FEBS Lett. 284:31-33(1991).

Comments

FUNCTION: May be important in regulation of neurosecretion.
SUBCELLULAR LOCATION: Secretogranin-2: Cytoplasmic vesicle, secretory vesicle (By similarity).
SUBCELLULAR LOCATION: Secretoneurin: Secreted (By similarity).
SIMILARITY: Belongs to the chromogranin/secretogranin protein family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U68757; AAB17470.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S74239; S74239.

3D structure databases

ModBase

P30945.

Family and domain databases

InterPro

IPR001990; Granin.
Graphical view of domain structure.

Pfam

PF01271; Granin; 1.
Pfam graphical view of domain structure.

PROSITE

PS00422; GRANINS_1; FALSE_NEG.

BLOCKS

P30945.

Phylogenomic databases

HOVERGEN

P30945; -.

Other

ProtoNet

P30945.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cleavage on pair of basic residues; Cytoplasmic vesicle; Direct protein sequencing; Secreted; Signal; Sulfation.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 30`	`30`	`By similarity.`
`CHAIN`	`31 601`	`571`	`Secretogranin-2.`	`PRO_0000005459`
`PEPTIDE`	`183 215`	`33`	`Secretoneurin.`	`PRO_0000005460`
`MOD_RES`	`151 151`		`Sulfotyrosine (By similarity).`

Sequence information

Length: 601 AA [This is the length of the unprocessed precursor]

Molecular weight: 69900 Da [This is the MW of the unprocessed precursor]

CRC64: 8D16FDAA1280A712 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSSQRNYCLA GCLSSCILVI LMSFSDAASF QYYQVPQQDQ EYRMKTLQRL PSPDMLKALE 

        70         80         90        100        110        120 
YIENLRKQAS RTESLPDYTS YQGAPFLSEQ KDTQALSTDT AKSPTSDDES EWMRAMLEAL 

       130        140        150        160        170        180 
MQAEKEAKVS PQEKNNLYMD KNIPPELIED YDSNKWSEKR PKAGKFSSRL YDDYSRDNPL 

       190        200        210        220        230        240 
KRTNEIVEGQ YTPQSLATLQ SVFQELGKLK GQANNKRDRM EEDQKLYKDD EDDLYKANNI 

       250        260        270        280        290        300 
AYEDVAGGED WNPIEEKVES QTQEELKESK EEVEKTDDME DEIKRSGLLG LQDEEPEKDT 

       310        320        330        340        350        360 
KEQESENLSN LMNTYLNMWM NRMDKGKQNP DRRSLRFSGK ELDPEAIYQL IDISRNLQIP 

       370        380        390        400        410        420 
PEDLIDMLRD EDGRKFGGRL ESEKEVDVPL DLDEVTETMT DKTNVYKNKQ GFVRQPTSPV 

       430        440        450        460        470        480 
LPNIPEGLTV EDMVNLMGAD KLQNRFKQNN GLQRPYPMLS KIKGHKAIWP KESEKRQIEY 

       490        500        510        520        530        540 
ESRPEKEEEL ADYVVKMLAK YPELLGNNQN KKMPIPYSAG DLQELEKQYE NALRGYVNMR 

       550        560        570        580        590        600 
GYQDLETVSS SNRRLSTREN DDTQNKQYID EDLLMKVLEY LNQEKAEKAR DHSVKRSMEN 


M

P30945 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools