[1]	PROTEIN SEQUENCE. TISSUE=Liver; PubMed=1554372 [NCBI, ExPASy, EBI, Israel, Japan] Tollersrud O.-K., Aronson N.N. Jr.; "Comparison of liver glycosylasparaginases from six vertebrates."; Biochem. J. 282:891-897(1992).

Comments

FUNCTION: Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
CATALYTIC ACTIVITY: N⁴-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H₂O = N-acetyl-beta-D-glucosaminylamine + L-aspartate.
SUBUNIT: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
SUBCELLULAR LOCATION: Lysosome.
SIMILARITY: Belongs to the Ntn-hydrolase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

3D structure databases

Ontologies

GO:0005764;	Cellular component: lysosome (inferred from electronic annotation from UniProtKB-KW).
GO:0003948;	Molecular function: N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

Phylogenomic databases

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Hydrolase; Lysosome.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 >17`	`>17`	`Glycosylasparaginase alpha chain.`	`PRO_0000002337`
`CHAIN`	`18 >34`	`>17`	`Glycosylasparaginase beta chain.`	`PRO_0000002338`
`NON_CONS`	`17 18`
`NON_TER`	`34 34`

Sequence information

Length: 34 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 3621 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: A527053E8DBA8B56 [This is a checksum on the sequence]

        10         20         30 
SXPLPLIVNT WPFKXATTIG MVVIHLKGYT AAGT

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools