[1]	NUCLEOTIDE SEQUENCE. PubMed=1340318 [NCBI, ExPASy, EBI, Israel, Japan] Samuelson J., Zhang W.W., Kumar A., Descoteaux S., Shen P.S., Bailey G.; "Primary structures of alcohol and aldehyde dehydrogenase genes of Entamoeba histolytica."; Arch. Med. Res. 23:31-33(1992).

Comments

CATALYTIC ACTIVITY: An aldehyde + NAD⁺ + H₂O = an acid + NADH.
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L05667; AAA19741.1; -; Unassigned_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P11883; 1AD3. [HSSP ENTRY / PDB]

ModBase

P30840.

Ontologies

GO:0004029;	Molecular function: aldehyde dehydrogenase (NAD) activity (inferred from electronic annotation from EC).
GO:0004030;	Molecular function: aldehyde dehydrogenase [NAD(P)+] activity (inferred from electronic annotation from InterPro).
GO:0006081;	Biological process: cellular aldehyde metabolic process (inferred from electronic annotation from InterPro).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR012394; Ald_DHase_NAD(P).
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.
PTHR11699:SF15; ALDH; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF036492; ALDH; 1.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; FALSE_NEG.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 529`	`529`	`Aldehyde dehydrogenase 1.`	`PRO_0000056432`
`NP_BIND`	`251 256`	`6`	`NAD (By similarity).`
`ACT_SITE`	`273 273`		`By similarity.`
`ACT_SITE`	`307 307`		`By similarity.`

Sequence information

Length: 529 AA [This is the length of the unprocessed precursor]

Molecular weight: 59774 Da [This is the MW of the unprocessed precursor]

CRC64: 441DDA2E8DEA0961 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEAYVLSLSD VLFNILFIGV CILSVLLLIS HALKYIIGDS KEKKLFNQRL EQIKNQQPLE 

        70         80         90        100        110        120 
PTKYQDIQTI CKTLKESYST NALRHLDARK EVLYCLYRMV LDNKQAISNA IREDLHRDVG 

       130        140        150        160        170        180 
MCVAEVNSVI HEINFLRKNL NKYLKRKQVP TVCAQLFGKS FVEREPYGCV CVISPWNFPA 

       190        200        210        220        230        240 
NLSLIPCAGA LACGNTVFLK MSKYSMATSK LIAELCDKYI PSEYLRCEYL TGREAIQECC 

       250        260        270        280        290        300 
SASFDYYFFT GSTYVGKLIN QAAAEKMVPA TLELGGKNPA IVDKSVNLKV AAKRIAWAKS 

       310        320        330        340        350        360 
INAGQICVCV DHVFVPRSIK NEFCEAVKNS FIKFFGEDQK KSEDFGRIIT KSAAKKMKEI 

       370        380        390        400        410        420 
IDQSDVYYGG EVDIENKYVQ PTILQNVKID DLCMKEEIFG PILPVIEYDT LDEVFEMVKQ 

       430        440        450        460        470        480 
HPNPLACYVF TEDNDMFEHV IANINSGAIY NNDSIVHLLN PNLPFGGNCQ SGIGCYHGKY 

       490        500        510        520 
TFDTFSRPRA VCNGHTSFDL SLKDWPFTSF QSWAVDRMAA SEIPVVSYL

P30840 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools