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UniProtKB/Swiss-Prot entry P30839

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AL3A2_RAT
Primary accession number P30839
Secondary accession numbers None
Integrated into Swiss-Prot on July 1, 1993
Sequence was last modified on July 1, 1993 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 70)
Name and origin of the protein
Protein name Fatty aldehyde dehydrogenase
Synonyms EC 1.2.1.3
Aldehyde dehydrogenase family 3 member A2
Aldehyde dehydrogenase 4
Microsomal aldehyde dehydrogenase
msALDH
Gene name
Name: Aldh3a2
Synonyms: Aldh4
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 93-110; 236-255 AND 408-427.
TISSUE=Liver;
PubMed=1717467 [NCBI, ExPASy, EBI, Israel, Japan]
Miyauchi K., Masaki R., Taketani S., Yamamoto A., Akayama M., Tashiro Y.;
"Molecular cloning, sequencing, and expression of cDNA for rat liver microsomal aldehyde dehydrogenase.";
J. Biol. Chem. 266:19536-19542(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M73714; AAA41555.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A41028; A41028.
RefSeq NP_113919.2; -.
UniGene Rn.9113
3D structure databases
HSSP P11883; 1AD3. [HSSP ENTRY / PDB]
ModBase P30839.
Organism-specific databases
RGD 61866; Aldh3a2.
Gene expression databases
ArrayExpress P30839; -.
GermOnline ENSRNOG00000002342; Rattus norvegicus.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0004029; Molecular function: aldehyde dehydrogenase (NAD) activity (inferred from electronic annotation from EC).
GO:0004030; Molecular function: aldehyde dehydrogenase [NAD(P)+] activity (inferred from electronic annotation from InterPro).
GO:0006081; Biological process: cellular aldehyde metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR012394; Ald_DHase_NAD(P).
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
PTHR11699:SF15; ALDH; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036492; ALDH; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS P30839.
ProtoNet P30839.
Genome annotation databases
Ensembl ENSRNOG00000002342; Rattus norvegicus. [Contig view]
GeneID 65183; -.
KEGG rno:65183; -.
Phylogenomic databases
HOVERGEN P30839; -.
Other
NextBio 614089; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Endoplasmic reticulum; Membrane; NAD; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   484  484     Fatty aldehyde dehydrogenase. PRO_0000056476
TOPO_DOM   1   463  463     Cytoplasmic. 
TRANSMEM   464   480  17     Potential. 
NP_BIND   185   190  6     NAD (Potential). 
MOTIF   481   484  4     Prevents secretion from ER (By similarity). 
ACT_SITE   207   207        By similarity. 
ACT_SITE   241   241        By similarity. 
Sequence information
Length: 484 AA [This is the length of the unprocessed precursor] Molecular weight: 54082 Da [This is the MW of the unprocessed precursor] CRC64: 9F50CB34AB64C31D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MERQVQRLRQ TFRSGRSRPL RFRLQQLEAL RRMVQEREKD ILAAIAADLS KSELNAYSHE 

        70         80         90        100        110        120 
VITILGEIDF MLGNLPELAS ARPAKKNLLT MMDEAYVQPE PLGVVLIIGA WNYPFVLTLQ 

       130        140        150        160        170        180 
PLVGAIAAGN AAIVKPSELS ENTAKILAEL LPQYLDQDLY MIVNGGVEET TELLRQRFDH 

       190        200        210        220        230        240 
ILYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDRDC DLDVACRRIT WGKYMNCGQT 

       250        260        270        280        290        300 
CIAPDYILCE ASSQDQIVQK IKDTVKDFYG ENVKASPDYE RIINLRHFKR IKSLLEGQKI 

       310        320        330        340        350        360 
AFGGETDEAT RYIAPTILTD VDPNSKVMQE EIFGPILPIV SVKNVEEAIN FINDREKPLA 

       370        380        390        400        410        420 
LYIFSHNNKL IKRVIDETSS GGVTGNDVIM HFTVNSLPFG GVGASGMGAY HGKYSFDTFS 

       430        440        450        460        470        480 
HQRPCLLKGL KGESVNKLRY PPNSESKVSW SKFFLLKQFN KGRLQLLLLV CLVAVAAVIV 


KDQL
P30839 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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