NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Heart;
PubMed=1528892 [NCBI, ExPASy, EBI, Israel, Japan]
Katsushika S., Chen L., Kawabe J., Nilakantan R., Halnon N.J., Homcy C.J., Ishikawa Y.;
"Cloning and characterization of a sixth adenylyl cyclase isoform: types V and VI constitute a subgroup within the mammalian adenylyl cyclase family.";
Proc. Natl. Acad. Sci. U.S.A. 89:8774-8778(1992).

Comments

FUNCTION: Membrane-bound, calcium-inhibitable adenylyl cyclase.
CATALYTIC ACTIVITY: ATP = 3',5'-cyclic AMP + diphosphate.
COFACTOR: Binds 2 magnesium ions per subunit (By similarity).
ENZYME REGULATION: Inhibition by calcium in the submicromolar concentration range.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
SIMILARITY: Contains 2 guanylate cyclase domains.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M94968; -; NOT_ANNOTATED_CDS; mRNA.

[EMBL / GenBank / DDBJ]

PIR

A46180; A46180.

3D structure databases

HSSP

P30803; 1AZS. [HSSP ENTRY / PDB]

SMR

P30804; 362-550.

ModBase

P30804.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0004016;	Molecular function: adenylate cyclase activity (inferred from electronic annotation from InterPro).
GO:0000287;	Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006171;	Biological process: cAMP biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0007242;	Biological process: intracellular signaling cascade (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR001054; A/G_cyclase.
IPR009398; Aden_cycl_like.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.70.1230; A/G_cyclase; 2.

Pfam

PF06327; DUF1053; 1.
PF00211; Guanylate_cyc; 2.
Pfam graphical view of domain structure.

SMART

SM00044; CYCc; 2.
SMART graphical view of domain structure.

PROSITE

PS00452; GUANYLATE_CYCLASE_1; 2.
PS50125; GUANYLATE_CYCLASE_2; 2.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSCAFG00000008907; Canis familiaris. [Contig view]

Phylogenomic databases

HOVERGEN

P30804; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

cAMP biosynthesis; Glycoprotein; Lyase; Magnesium; Membrane; Metal-binding; Phosphoprotein; Repeat; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 1165`	`1165`	`Adenylate cyclase type 6.`	`PRO_0000195698`
`TOPO_DOM`	`1 149`	`149`	`Cytoplasmic (Potential).`
`TRANSMEM`	`150 166`	`17`	`Potential.`
`TRANSMEM`	`179 195`	`17`	`Potential.`
`TRANSMEM`	`212 228`	`17`	`Potential.`
`TRANSMEM`	`237 253`	`17`	`Potential.`
`TRANSMEM`	`257 273`	`17`	`Potential.`
`TRANSMEM`	`287 303`	`17`	`Potential.`
`TOPO_DOM`	`304 670`	`367`	`Cytoplasmic (Potential).`
`TRANSMEM`	`671 688`	`18`	`Potential.`
`TRANSMEM`	`699 715`	`17`	`Potential.`
`TRANSMEM`	`740 756`	`17`	`Potential.`
`TOPO_DOM`	`757 816`	`60`	`Extracellular (Potential).`
`TRANSMEM`	`817 833`	`17`	`Potential.`
`TRANSMEM`	`836 852`	`17`	`Potential.`
`TRANSMEM`	`894 910`	`17`	`Potential.`
`TOPO_DOM`	`911 1165`	`255`	`Cytoplasmic (Potential).`
`METAL`	`382 382`		`Magnesium 1 (By similarity).`
`METAL`	`382 382`		`Magnesium 2 (By similarity).`
`METAL`	`383 383`		`Magnesium 2; via carbonyl oxygen (By similarity).`
`METAL`	`426 426`		`Magnesium 1 (By similarity).`
`METAL`	`426 426`		`Magnesium 2 (By similarity).`
`MOD_RES`	`53 53`		`Phosphoserine (By similarity).`
`MOD_RES`	`573 573`		`Phosphoserine (By similarity).`
`CARBOHYD`	`790 790`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`875 875`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 1165 AA [This is the length of the unprocessed precursor]

Molecular weight: 130324 Da [This is the MW of the unprocessed precursor]

CRC64: BA9D2D329120615E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSWFSGLLVP KVDERKTAWG ERNGQKRPRR GTRTSGFCTP RYMSCLRDAQ PPSPTPAAPP 

        70         80         90        100        110        120 
RCPWQDEAFI RRGGPGKGTE LGLRAVALGF EDTEAMSAVG AAGGGPDVTP GSRRSCWRRL 

       130        140        150        160        170        180 
AQVFQSKQFR SAKLERLYQR YFFQMNQSSL TLLMAVLVLL TAVLLAFHAA PARPQPAYVA 

       190        200        210        220        230        240 
LLACAATLFV ALMVVCNRHS FRQDSMWVVS YVVLGILAAV QVGGALAANP RSPSVGLWCP 

       250        260        270        280        290        300 
VFFVYITYTL LPIRMRAAVF SGLGLSTLHL ILAWQLNRGD AFLWKQLGAN MLLFLCTNVI 

       310        320        330        340        350        360 
GICTHYPAEV SQRQAFQETR GYIQARLHLP DENRQQERLL LSVLPQHVAM EMKEDINTKK 

       370        380        390        400        410        420 
EDMMFHKIYI QKHDNVSILF ADIEGFTSLA SQCTAQELVM TLNELFARFD KLAAENHCLR 

       430        440        450        460        470        480 
IKILGDCYYC VSGLPEARAD HAHCCVEMGV DMIEAISLVR EVTGVNVNMR VGIHSGRVHC 

       490        500        510        520        530        540 
GVLGLRKWQF DVWSNDVTLA NHMEAARAGR IHITRATLQY LNGDYEVEPG RGGERNAYLK 

       550        560        570        580        590        600 
EQHIETFLIL GASQKRKEEK AMLAKLQRTR ANSMEGLMPR WVPDRAFSRT KDSKAFRQMG 

       610        620        630        640        650        660 
IDDSSKDNRG AQDALNPEDE VDEFLGRAID ARSIDQLRKD HVRRFLLTFQ REDLEKKYSR 

       670        680        690        700        710        720 
KVDPRFGAYV ACALLVFCFI CFIQLLVFPH STVMLGIYAS IFVLLLITVL TCAVYSCGSL 

       730        740        750        760        770        780 
FPKALRRLSR SIVRSRAHST VVGIFSVLLV FTSAIANMFT CNHTPIRTCA ARMLNVTPAD 

       790        800        810        820        830        840 
ITACHLQQLN YSLGLDAPLC EGTAPTCSFP EYFVGNMLLS LLASSVFLHI SSIGKLAMIF 

       850        860        870        880        890        900 
VLGLIYLVLL LLGPPSTIFD NYDLLLGVHG LASSNDTFDG LDCPAAGRVA LKYMTPVILL 

       910        920        930        940        950        960 
VFALALYLHA QQVESTARLD FLWKLQATGE KEEMEELQAY NRRLLHNILP KDVAAHFLAR 

       970        980        990       1000       1010       1020 
ERRNDELYYQ SCECVAVMFA SIANFSEFYV ELEANNEGVE CLRLLNEIIA DFDEIISEER 

      1030       1040       1050       1060       1070       1080 
FRQLEKIKTI GSTYMAASGL NASTYDQAGR SHITALADYA MRLMEQMKHI NEHSFNNFQM 

      1090       1100       1110       1120       1130       1140 
KIGLNMGPVV AGVIGARKPQ YDIWGNTVNV SSRMDSTGVP DRIQVTTDLY QVLAAKRYQL 

      1150       1160 
ECRGVVKVKG KGEMTTYFLN GGPPS

P30804 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools