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UniProtKB/Swiss-Prot entry P30645


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PDE2_CAEEL
Primary accession number P30645
Secondary accession numbers Q65ZC7 Q7JMU8
Integrated into Swiss-Prot on April 1, 1993
Sequence was last modified on July 30, 2004 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 58)
Name and origin of the protein
Protein name Probable 3',5'-cyclic phosphodiesterase pde-2
Synonym EC 3.1.4.17
Gene name
Name: pde-2
ORFNames: R08D7.6
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1038/368032a0; PubMed=7906398 [NCBI, ExPASy, EBI, Israel, Japan]
Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P.;
"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.";
Nature 368:32-38(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z12017; CAA78052.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z12017; CAE47469.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z12017; CAH19088.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D88544; D88544.
S41041; S24462.
RefSeq NP_001022705.1; -.
UniGene Cel.6004
3D structure databases
ModBase P30645.
Organism-specific databases
WormBase WBGene00011146; pde-2.
WormPep R08D7.6a; CE35749. [WormPep / WorfDB]
R08D7.6b; CE35750. [WormPep / WorfDB]
R08D7.6c; CE37267. [WormPep / WorfDB]
Gene expression databases
ArrayExpress P30645; -.
Ontologies
GO
GO:0004114; Molecular function: 3',5'-cyclic-nucleotide phosphodiesterase activity (inferred from electronic annotation from InterPro).
GO:0007165; Biological process: signal transduction (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR003018; GAF.
IPR003607; Met-dep_phosphohydro_HD.
IPR002073; PDEase.
Graphical view of domain structure.
Pfam PF01590; GAF; 1.
PF00233; PDEase_I; 1.
Pfam graphical view of domain structure.
PRINTS PR00387; PDIESTERASE1.
SMART SM00065; GAF; 1.
SM00471; HDc; 1.
SMART graphical view of domain structure.
PROSITE PS00126; PDEASE_I; 1.
BLOCKS P30645.
ProtoNet P30645.
Genome annotation databases
Ensembl R08D7.6; Caenorhabditis elegans. [Contig view]
GeneID 176270; -.
KEGG cel:R08D7.6; -.
Other
NextBio 891854; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; cGMP; Complete proteome; Hydrolase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   859  859     Probable 3',5'-cyclic phosphodiesterase pde-2. PRO_0000198845
DOMAIN   177   312  136     GAF. 
VAR_SEQ   48    50        Missing (in isoform c). VSP_014355
VAR_SEQ   692   734        GTFYSEKQEMEICEKPKKLMLEFIFFKTIYDRVRKQDP RAAEI -> DIRSSAKARPKSCRNCFKTVRACICKRKCSSNTRYFGS SFRWI (in isoform b). VSP_011155
VAR_SEQ   735   859        Missing (in isoform b). VSP_011156
Sequence information
Length: 859 AA [This is the length of the unprocessed precursor] Molecular weight: 97770 Da [This is the MW of the unprocessed precursor] CRC64: 3CDE777017E08455 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLELRRNSSP SSAHPSPQTN CQNSQRGDGL HHHHHEAASG STCCGGMTVF TGANAAKSSN 

        70         80         90        100        110        120 
EPAGSASPTV WRKTSHPPLH FNNNETRNRN LQMQLKNRGT KDDWGASLRY DIEEPTSSGL 

       130        140        150        160        170        180 
LELLPDVPIV RKLSRPLVKM DDQDDACSVA SNESDRTVLS PLVPMSIFDQ FLCLTNNLSA 

       190        200        210        220        230        240 
LISCIIAEAK KNTEAEDYAV FLHDEDNKQM VLFNNETMLM TGKKFDMGYG IVGKVASTMR 

       250        260        270        280        290        300 
TMNIRDVSRC PFFNEEIDEQ FSIKARNLIA FPLIDSSCSL IGVIVLYNKE NGFSRHDEKY 

       310        320        330        340        350        360 
IKRFSYFVAN SIAHAILAKQ IEEVRTRIHM VEEFKIQGED AVIEEVDIMR LVNDPLRDWR 

       370        380        390        400        410        420 
YFSQNFADFS FPPRSVGENH FHRASMMFFE DLGFSMLYKL NKRKLSYLVL RVSAGYRPVP 

       430        440        450        460        470        480 
YHNWSHAFAV THFCWLTLRT DAIRRALSDM ERLSLLIACL CHDIDHRGTT NSFQMQSLQK 

       490        500        510        520        530        540 
TPLSVLYSTE GSVLERHHFA QTIKLLQQEE CSILENLPAA DFRTIVNTIR EVILATDISA 

       550        560        570        580        590        600 
HLRKQERIKT MISEGYNPMS FDHRYLLMCL VMTASDLSDQ AKNFHNAKRI AENIYLEFFA 

       610        620        630        640        650        660 
QGDLELQLGV KPLEMMDRTN AYVPTVQIDF LFKIGVPVFQ LLASVVPEGR TTSEAIDANH 

       670        680        690        700        710        720 
LCWVALDEEV RNNPSATKYT RVFARRESRT EGTFYSEKQE MEICEKPKKL MLEFIFFKTI 

       730        740        750        760        770        780 
YDRVRKQDPR AAEIASKRFE PVYANGSVPQ TQDILDHRFD GYDKKYQIGC SGGQNQSNGK 

       790        800        810        820        830        840 
QQQIRSLQKI RSKTSEDDAL LKPMDNGGSV AASSTRRGSR TPRRLWRRAR QLISSMSSSC 

       850 
ASCSPLPSRR QVSEDSESC 

P30645 in FASTA format

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