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UniProtKB/Swiss-Prot entry P30635

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GSHR_CAEEL
Primary accession number P30635
Secondary accession numbers None
Integrated into Swiss-Prot on April 1, 1993
Sequence was last modified on November 1, 1997 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 79)
Name and origin of the protein
Protein name Probable glutathione reductase 2
Synonyms GRase
GR
EC 1.8.1.7
Gene name
Name: trxr-2
ORFNames: ZK637.10
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1038/356037a0; PubMed=1538779 [NCBI, ExPASy, EBI, Israel, Japan]
Sulston J., Du Z., Thomas K., Wilson R., Hillier L., Staden R., Halloran N., Green P., Thierry-Mieg J., Qiu L., Dear S., Coulson A., Craxton M., Durbin R., Berks M., Metzstein M., Hawkins T., Ainscough R., Waterston R.;
"The C. elegans genome sequencing project: a beginning.";
Nature 356:37-41(1992).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z11115; CAA77459.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D88542; D88542.
S15798; S15798.
RefSeq NP_498971.1; -.
UniGene Cel.9538
3D structure databases
HSSP Q94655; 1ONF. [HSSP ENTRY / PDB]
ModBase P30635.
Organism-specific databases
WormBase WBGene00014028; trxr-2.
WormPep ZK637.10; CE15373. [WormPep / WorfDB]
Gene expression databases
ArrayExpress P30635; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0050660; Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0004362; Molecular function: glutathione-disulfide reductase activity (inferred from electronic annotation from EC).
GO:0050661; Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0016654; Molecular function: oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor (inferred from electronic annotation from InterPro).
GO:0045454; Biological process: cell redox homeostasis (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR000815; Hg_reductase.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
IPR012999; Pyr_OxRdtase_I_AS.
IPR001327; Pyr_OxRdtase_NAD_bd.
IPR006338; Reduct_Se.
Graphical view of domain structure.
Gene3D G3DSA:3.30.390.30; Pyr_redox_dim; 1.
PANTHER PTHR22912:SF23; Reduct_Se; 1.
Pfam PF00070; Pyr_redox; 1.
PF07992; Pyr_redox_2; 1.
PF02852; Pyr_redox_dim; 1.
Pfam graphical view of domain structure.
PRINTS PR00368; FADPNR.
PR00945; HGRDTASE.
PR00411; PNDRDTASEI.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01438; TGR; 1.
PROSITE PS00076; PYRIDINE_REDOX_1; 1.
BLOCKS P30635.
ProtoNet P30635.
Genome annotation databases
Ensembl ZK637.10; Caenorhabditis elegans. [Contig view]
GeneID 176259; -.
KEGG cel:ZK637.10; -.
NMPDR fig|6239.3.peg.11001; -.
Other
NextBio 891814; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; FAD; Flavoprotein; NADP; Oxidoreductase; Redox-active center.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   503  503     Probable glutathione reductase 2. PRO_0000067958
NP_BIND   58    67  10     FAD (By similarity). 
ACT_SITE   476   476        Proton acceptor (By similarity). 
DISULFID   67    72        Redox-active (By similarity). 
Sequence information
Length: 503 AA [This is the length of the unprocessed precursor] Molecular weight: 55046 Da [This is the MW of the unprocessed precursor] CRC64: CE2385C9ACBD9AD2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLLSTFKRHL PIRRLFSSNK FDLIVIGAGS GGLSCSKRAA DLGANVALID AVEPTPHGHS 

        70         80         90        100        110        120 
WGIGGTCANV GCIPKKLMHQ AAIVGKELKH ADKYGWNGID QEKIKHDWNV LSKNVNDRVK 

       130        140        150        160        170        180 
ANNWIYRVQL NQKKINYFNA YAEFVDKDKI VITGTDKNKT KNFLSAPNVV ISTGLRPKYP 

       190        200        210        220        230        240 
NIPGAELGIT SDDLFTLASV PGKTLIVGGG YVALECAGFL SAFNQNVEVL VRSIPLKGFD 

       250        260        270        280        290        300 
RDCVHFVMEH LKTTGVKVKE HVEVERVEAV GSKKKVTFTG NGGVEEYDTV IWAAGRVPNL 

       310        320        330        340        350        360 
KSLNLDNAGV RTDKRSGKIL ADEFDRASCN GVYAVGDIVQ DRQELTPLAI QSGKLLADRL 

       370        380        390        400        410        420 
FSNSKQIVRF DGVATTVFTP LELSTVGLTE EEAIQKHGED SIEVFHSHFT PFEYVVPQNK 

       430        440        450        460        470        480 
DSGFCYVKAV CTRDESQKIL GLHFVGPNAA EVIQGYAVAF RVGISMSDLQ NTIAIHPCSS 

       490        500 
EEFVKLHITK RSGQDPRTQG CCG
P30635 in FASTA format

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