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UniProtKB/Swiss-Prot entry P30615

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KPYK1_TRYBB
Primary accession number P30615
Secondary accession numbers None
Integrated into Swiss-Prot on April 1, 1993
Sequence was last modified on April 1, 1993 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 50)
Name and origin of the protein
Protein name Pyruvate kinase 1
Synonyms PK 1
EC 2.7.1.40
Gene name
Name: PYK1
From
Trypanosoma brucei brucei [TaxID: 5702] 
Taxonomy Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=427;
PubMed=1879424 [NCBI, ExPASy, EBI, Israel, Japan]
Allert S., Ernest I., Poliszczak A., Opperdoes F.R., Michels P.A.M.;
"Molecular cloning and analysis of two tandemly linked genes for pyruvate kinase of Trypanosoma brucei.";
Eur. J. Biochem. 200:19-27(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X57950; CAA41018.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S17648; S17648.
3D structure databases
HSSP Q27686; 1PKL. [HSSP ENTRY / PDB]
SMR P30615; 2-496.
ModBase P30615.
Ontologies
GO
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from InterPro).
GO:0030955; Molecular function: potassium ion binding (inferred from electronic annotation from InterPro).
GO:0004743; Molecular function: pyruvate kinase activity (inferred from electronic annotation from InterPro).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001697; Pyr_Knase.
IPR015813; Pyrv/PenolPyrv_Kinase_cat.
IPR015794; Pyrv_Knase_a/b.
IPR015793; Pyrv_Knase_brl.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.60; Pyrv/PenolPyrv_Kinase_cat; 1.
G3DSA:3.40.1380.20; Pyrv_Knase_a/b; 1.
PANTHER PTHR11817; Pyruvate_kinase; 1.
Pfam PF00224; PK; 1.
PF02887; PK_C; 1.
Pfam graphical view of domain structure.
PRINTS PR01050; PYRUVTKNASE.
ProDom PD001009; Pyruvate_kinase; 2.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01064; pyruv_kin; 1.
PROSITE PS00110; PYRUVATE_KINASE; 1.
BLOCKS P30615.
ProtoNet P30615.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycolysis; Kinase; Magnesium; Metal-binding; Pyruvate; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   499  499     Pyruvate kinase 1. PRO_0000112103
ACT_SITE   239   239        By similarity. 
METAL   241   241        Magnesium (Potential). 
METAL   262   262        Magnesium (Potential). 
METAL   263   263        Magnesium (Potential). 
Sequence information
Length: 499 AA [This is the length of the unprocessed precursor] Molecular weight: 54467 Da [This is the MW of the unprocessed precursor] CRC64: 1D40AD5352B272C6 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSQLEHNIGL SIFEPVAKHR ANRIVCTIGP STQSVEALKN LMKSGMSVAR MNFSHGSHEY 

        70         80         90        100        110        120 
HQTTINNVRA AAAELGLHIG IALDTKGPEI RTGLFKDGEV SFAPGDIVCV TTDPAYEKVG 

       130        140        150        160        170        180 
TKEKFYIDYP QLTNAVRPGG SIYVDDGVMT LRVVSKEDDR TLKCHVNNHH RLTDRRGINL 

       190        200        210        220        230        240 
PGCEVDLPAV SEKDRKDLEF GVAQGVDMIF ASFIRTAEQV REVRAALGEK GKDILIISKI 

       250        260        270        280        290        300 
ENHQGVQNID SIIEASNGIM VARGDLGVEI PAEKVCVAQM CIISKCNVVG KPVICATQML 

       310        320        330        340        350        360 
ESMTSNPRPT RAEVSDVANA VLNGADCVML SGETAKGKYP NEVVQYMARI CVEAQSATHD 

       370        380        390        400        410        420 
TVMFNSIKNL QKIPMCPEEA VCSSAVASAF EVQAKAMLVL SNTGRSARLI SKYRPNCPII 

       430        440        450        460        470        480 
CVTTRLQTCR QLNVTRSVVS VFYDAAKSGE DKDKEKRVKL GLDFAKKEKY ASTGDVVVVV 

       490 
HADHSVKGYP NQTRLIYLP
P30615 in FASTA format

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