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UniProtKB/Swiss-Prot entry P30542


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AA1R_HUMAN
Primary accession number P30542
Secondary accession numbers A6NFY5 A6NGP4 A8K1L3 B3KXQ4 Q6FHK3 Q8TAM8
Integrated into Swiss-Prot on April 1, 1993
Sequence was last modified on April 1, 1993 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 91)
Name and origin of the protein
Protein name Adenosine receptor A1
Synonyms None
Gene name
Name: ADORA1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Hippocampus;
DOI=10.1016/0006-291X(92)91285-X; PubMed=1530647 [NCBI, ExPASy, EBI, Israel, Japan]
Libert F., van Sande J., Lefort A., Czernilofsky A., Dumont J.E., Vassart G., Ensinger H.A., Mendla K.D.;
"Cloning and functional characterization of a human A1 adenosine receptor.";
Biochem. Biophys. Res. Commun. 187:919-926(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Brain;
DOI=10.1016/0169-328X(92)90248-A; PubMed=1339301 [NCBI, ExPASy, EBI, Israel, Japan]
Townsend-Nicholson A., Shine J.;
"Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA.";
Brain Res. Mol. Brain Res. 16:365-370(1992).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Hippocampus;
PubMed=8300646 [NCBI, ExPASy, EBI, Israel, Japan]
Ren H., Stiles G.L.;
"Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing.";
J. Biol. Chem. 269:3104-3110(1994).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Brain;
Salvatore C.A., Luneau C.J., Johnson R.G., Jacobson M.;
Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Heart;
Hirabatake Y., Takao K., Hagiwara S., Kasanuki H., Hosoda S., Kokubun S.;
"Complete nucleotide sequence of an adenosine A1-receptor from heart.";
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain, and Hippocampus;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).";
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[10]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[11]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[12]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS SER-43; PRO-50; HIS-105 AND GLN-261.
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[13]
VARIANT [LARGE SCALE ANALYSIS] LYS-170.
DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan]
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
S45235; AAB23388.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S56143; AAB25533.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L22214; AAA17544.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X68485; CAA48503.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB004662; BAA20433.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK127752; BAG54566.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK289928; BAF82617.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY136746; AAN01272.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT019854; AAV38657.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR541749; CAG46549.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC105940; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
CH471067; EAW91465.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC026340; AAH26340.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00026872; -.
IPI00645335; -.
PIR A53005; A53005.
RefSeq NP_000665.1; -.
NP_001041695.1; -.
UniGene Hs.77867
3D structure databases
HSSP P29274; 1MMH. [HSSP ENTRY / PDB]
ModBase P30542.
Protein family/group databases
GPCRDB P30542; AA1R_HUMAN.
Organism-specific databases
GeneCards GC01P201326; -.
H-InvDB HIX0001486; -.
HGNC HGNC:262; ADORA1.
GenAtlas ADORA1.
MIM 102775; gene. [NCBI / EBI]
PharmGKB PA24583; -.
Gene expression databases
Bgee P30542; -.
CleanEx HS_ADORA1; -.
GermOnline ENSG00000163485; Homo sapiens.
Ontologies
GO
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0001609; Molecular function: adenosine receptor activity, G-protein coupled (inferred from electronic annotation from InterPro).
GO:0007267; Biological process: cell-cell signaling (traceable author statement from ProtInc).
GO:0007186; Biological process: G-protein coupled receptor protein signaling pathway (inferred from electronic annotation from UniProtKB-KW).
GO:0008624; Biological process: induction of apoptosis by extracellular signals (traceable author statement from ProtInc).
GO:0006954; Biological process: inflammatory response (traceable author statement from ProtInc).
GO:0007399; Biological process: nervous system development (traceable author statement from ProtInc).
GO:0006909; Biological process: phagocytosis (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR000276; 7TM_GPCR_Rhodpsn.
IPR001068; Adeno_A1_rcpt.
IPR001634; Adenosn_rcpt.
IPR017452; GPCR_Rhodpsn_supfam.
Graphical view of domain structure.
PANTHER PTHR19266:SF15; Adeno_A1_rcpt; 1.
Pfam PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00552; ADENOSINEA1R.
PR00424; ADENOSINER.
PR00237; GPCRRHODOPSN.
PROSITE PS00237; G_PROTEIN_RECEP_F1_1; 1.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE P30542; -.
Genome annotation databases
Ensembl ENSG00000163485; Homo sapiens. [Contig view]
GeneID 134; -.
KEGG hsa:134; -.
Phylogenomic databases
HOGENOM P30542; -.
HOVERGEN P30542; -.
OMA P30542; VLIYLEV.
Other
DrugBank DB01223; Aminophylline.
DB00201; Caffeine.
DB04932; Defibrotide.
DB00996; Gabapentin.
DB00458; Imipramine.
DB00061; Pegademase bovine.
DB00277; Theophylline.
NextBio 537; -.
SOURCE ADORA1; Homo sapiens.
GPCRDB-Snakes P30542.
ProtoNet P30542.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate; Polymorphism; Receptor; Transducer; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   326  326     Adenosine receptor A1. PRO_0000068991
TOPO_DOM   1    10  10     Extracellular (Potential). 
TRANSMEM   11    33  23     1 (Potential). 
TOPO_DOM   34    46  13     Cytoplasmic (Potential). 
TRANSMEM   47    69  23     2 (Potential). 
TOPO_DOM   70    80  11     Extracellular (Potential). 
TRANSMEM   81   102  22     3 (Potential). 
TOPO_DOM   103   123  21     Cytoplasmic (Potential). 
TRANSMEM   124   146  23     4 (Potential). 
TOPO_DOM   147   176  30     Extracellular (Potential). 
TRANSMEM   177   201  25     5 (Potential). 
TOPO_DOM   202   235  34     Cytoplasmic (Potential). 
TRANSMEM   236   259  24     6 (Potential). 
TOPO_DOM   260   267  8     Extracellular (Potential). 
TRANSMEM   268   292  25     7 (Potential). 
TOPO_DOM   293   326  34     Cytoplasmic (Potential). 
LIPID   309   309        S-palmitoyl cysteine (Potential). 
CARBOHYD   159   159        N-linked (GlcNAc...) (Potential). 
DISULFID   80   169        By similarity. 
VAR_SEQ   115   125        YKMVVTPRRAA -> RISQCMASTKS (in isoform 2). VSP_034401
VAR_SEQ   126   326        Missing (in isoform 2). VSP_034402
VARIANT   43    43  1     A -> S (in dbSNP:rs11547175 [NCBI]). VAR_044138 
VARIANT   50    50  1     S -> P (in dbSNP:rs11547174 [NCBI]). VAR_044139 
VARIANT   105   105  1     R -> H (in dbSNP:rs11547176 [NCBI]). VAR_044140 
VARIANT   170   170  1     E -> K (in a colorectal cancer sample; somatic mutation). VAR_035754 
VARIANT   261   261  1     P -> Q (in dbSNP:rs17852405 [NCBI]). VAR_044141 
CONFLICT   312   312        A -> T (in Ref. 6; BAF82617). 
Sequence information
Length: 326 AA [This is the length of the unprocessed precursor] Molecular weight: 36512 Da [This is the MW of the unprocessed precursor] CRC64: 1B555893BCDEC9A6 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA 

        70         80         90        100        110        120 
LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA IAVDRYLRVK IPLRYKMVVT 

       130        140        150        160        170        180 
PRRAAVAIAG CWILSFVVGL TPMFGWNNLS AVERAWAANG SMGEPVIKCE FEKVISMEYM 

       190        200        210        220        230        240 
VYFNFFVWVL PPLLLMVLIY LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL 

       250        260        270        280        290        300 
FLFALSWLPL HILNCITLFC PSCHKPSILT YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL 

       310        320 
KIWNDHFRCQ PAPPIDEDLP EERPDD 

P30542 in FASTA format

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