ID 1B42_HUMAN Reviewed; 362 AA. AC P30480; P79555; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 16-DEC-2008, entry version 78. DE RecName: Full=HLA class I histocompatibility antigen, B-42 alpha chain; DE AltName: Full=MHC class I antigen B*42; DE Flags: Precursor; GN Name=HLA-B; Synonyms=HLAB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE B*4201). RX MEDLINE=89235215; PubMed=2715640; RA Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.; RT "Diversity and diversification of HLA-A,B,C alleles."; RL J. Immunol. 142:3937-3950(1989). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*4202). RX MEDLINE=97387746; PubMed=9243763; RA Lardy N.M., Otting N., van de Weerd M.J., van de Horst A.R., RA Waal L.P., Bontrop R.E.; RT "Full-length cDNA nucleotide sequence of the HLA-B*4202 allele."; RL Tissue Antigens 50:83-84(1997). RN [3] RP NUCLEOTIDE SEQUENCE (ALLELE B*4201). RC TISSUE=Blood; RX MEDLINE=22512041; PubMed=12622774; RX DOI=10.1034/j.1399-0039.2003.610103.x; RA Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., RA Madrigal J.A., Little A.-M.; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). Interacts with human herpesvirus 8 MIR1 protein CC (By similarity). CC -!- INTERACTION: CC P23526:AHCY; NbExp=1; IntAct=EBI-1054175, EBI-1053240; CC P15311:EZR; NbExp=1; IntAct=EBI-1054175, EBI-1056902; CC P26038:MSN; NbExp=1; IntAct=EBI-1054175, EBI-528768; CC P22234:PAICS; NbExp=1; IntAct=EBI-1054175, EBI-712261; CC O15067:PFAS; NbExp=1; IntAct=EBI-1054175, EBI-1052653; CC P13797:PLS3; NbExp=1; IntAct=EBI-1054175, EBI-698052; CC Q99460:PSMD1; NbExp=1; IntAct=EBI-1054175, EBI-357874; CC Q9Y265:RUVBL1; NbExp=1; IntAct=EBI-1054175, EBI-353675; CC P26639:TARS; NbExp=1; IntAct=EBI-1054175, EBI-1042683; CC P29401:TKT; NbExp=1; IntAct=EBI-1054175, EBI-1050560; CC Q13263:TRIM28; NbExp=1; IntAct=EBI-1054175, EBI-78139; CC P26640:VARS; NbExp=1; IntAct=EBI-1054175, EBI-355765; CC Q5VYM0:VCP; NbExp=1; IntAct=EBI-1054175, EBI-1046421; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC -!- POLYMORPHISM: The following alleles of B-42 are known: B*4201 (Bw- CC 42) and B*4202. The sequence shown is that of B*4201. CC -!- SIMILARITY: Belongs to the MHC class I family. CC -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like) CC domain. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M24034; AAA59667.1; -; Genomic_DNA. DR EMBL; U88407; AAC16437.1; -; mRNA. DR EMBL; AJ309194; CAC38393.1; -; Genomic_DNA. DR PIR; I61865; I61865. DR UniGene; Hs.654404; -. DR UniGene; Hs.702915; -. DR UniGene; Hs.77961; -. DR HSSP; Q29961; 1HSA. DR SMR; P30480; 25-300. DR IntAct; P30480; 288. DR PRIDE; P30480; -. DR Ensembl; ENSG00000204525; Homo sapiens. DR HGNC; HGNC:4932; HLA-B. DR MIM; 142830; gene. DR PharmGKB; PA35056; -. DR HOVERGEN; P30480; -. DR Reactome; REACT_6900; Signaling in Immune System. DR ArrayExpress; P30480; -. DR CleanEx; HS_HLA-B; -. DR GermOnline; ENSG00000204523; Homo sapiens. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:InterPro. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR GO; GO:0002474; P:antigen processing and presentation of pept...; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1. DR Gene3D; G3DSA:3.30.500.10; MHC_I-like_Ag-recog; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR ProDom; PD000050; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Glycoprotein; Host-virus interaction; Immune response; Membrane; KW MHC I; Polymorphism; Signal; Transmembrane; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 362 HLA class I histocompatibility antigen, FT B-42 alpha chain. FT /FTId=PRO_0000018846. FT TOPO_DOM 25 309 Extracellular (Potential). FT TRANSMEM 310 333 Potential. FT TOPO_DOM 334 362 Cytoplasmic (Potential). FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 309 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) (By similarity). FT DISULFID 125 188 By similarity. FT DISULFID 227 283 By similarity. FT VARIANT 33 33 Y -> H (in allele B*4202). FT /FTId=VAR_016460. SQ SEQUENCE 362 AA; 40333 MW; C9155AB015DEA1BE CRC64; MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARVAEQD RAYLEGTCVE WLRRYLENGK DTLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA //