[1]	NUCLEOTIDE SEQUENCE (ALLELE B*4201). PubMed=2715640 [NCBI, ExPASy, EBI, Israel, Japan] Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.; "Diversity and diversification of HLA-A,B,C alleles."; J. Immunol. 142:3937-3950(1989).
[2]	NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B4202). PubMed=9243763 [NCBI, ExPASy, EBI, Israel, Japan] Lardy N.M., Otting N., van de Weerd M.J., van de Horst A.R., Waal L.P., Bontrop R.E.; "Full-length cDNA nucleotide sequence of the HLA-B4202 allele."; Tissue Antigens 50:83-84(1997).
[3]	NUCLEOTIDE SEQUENCE (ALLELE B4201). TISSUE*=Blood; DOI=10.1034/j.1399-0039.2003.610103.x; PubMed=12622774 [NCBI, ExPASy, EBI, Israel, Japan] Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., Madrigal J.A., Little A.-M.; "Cloning and sequencing full-length HLA-B and -C genes."; Tissue Antigens 61:20-48(2003).

Comments

FUNCTION: Involved in the presentation of foreign antigens to the immune system.
SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).
INTERACTION:
P23526:AHCY; NbExp=1; IntAct=EBI-1054175, EBI-1053240;
P15311:EZR; NbExp=1; IntAct=EBI-1054175, EBI-1056902;
P26038:MSN; NbExp=1; IntAct=EBI-1054175, EBI-528768;
P22234:PAICS; NbExp=1; IntAct=EBI-1054175, EBI-712261;
O15067:PFAS; NbExp=1; IntAct=EBI-1054175, EBI-1052653;
P13797:PLS3; NbExp=1; IntAct=EBI-1054175, EBI-698052;
Q99460:PSMD1; NbExp=1; IntAct=EBI-1054175, EBI-357874;
Q9Y265:RUVBL1; NbExp=1; IntAct=EBI-1054175, EBI-353675;
P26639:TARS; NbExp=1; IntAct=EBI-1054175, EBI-1042683;
P29401:TKT; NbExp=1; IntAct=EBI-1054175, EBI-1050560;
Q13263:TRIM28; NbExp=1; IntAct=EBI-1054175, EBI-78139;
P26640:VARS; NbExp=1; IntAct=EBI-1054175, EBI-355765;
Q5VYM0:VCP; NbExp=1; IntAct=EBI-1054175, EBI-1046421;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
PTM: Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).
POLYMORPHISM: The following alleles of B-42 are known: B*4201 (Bw-42) and B*4202. The sequence shown is that of B*4201.
SIMILARITY: Belongs to the MHC class I family.
SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M24034; AAA59667.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U88407; AAC16437.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ309194; CAC38393.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

I61865; I61865.

UniGene

Hs.654404

3D structure databases

HSSP

Q29961; 1HSA. [HSSP ENTRY / PDB]

SMR

P30480; 25-300.

ModBase

P30480.

Protein-protein interaction databases

IntAct

P30480; -.

Enzyme and pathway databases

Reactome

REACT_6900; Signaling in Immune System.

Organism-specific databases

HGNC:4932; HLA-B.

142830; gene. [NCBI / EBI]

PharmGKB

PA35056; -.

GeneCards

P30480.

Gene expression databases

ArrayExpress

P30480; -.

CleanEx

HS_HLA-B; -.

GermOnline

ENSG00000204523; Homo sapiens.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0042612;	Cellular component: MHC class I protein complex (inferred from electronic annotation from InterPro).
GO:0005515;	Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0002474;	Biological process: antigen processing and presentation of peptide antigen via MHC class I (inferred from electronic annotation from UniProtKB-KW).
GO:0006955;	Biological process: immune response (inferred from electronic annotation from InterPro).
GO:0044419;	Biological process: interspecies interaction between organisms (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003006; Ig/MHC_CS.
IPR003597; Ig_C1-set.
IPR011161; MHC_I-like_Ag-recog.
IPR001039; MHC_I_a_a1/a2.
IPR010579; MHC_I_a_C.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.10; Ig-like_fold; 1.
G3DSA:3.30.500.10; MHC_I-like_Ag-recog; 1.

Pfam

PF07654; C1-set; 1.
PF00129; MHC_I; 1.
PF06623; MHC_I_C; 1.
Pfam graphical view of domain structure.

PRINTS

PR01638; MHCCLASSI.

ProDom

PD000050; MHC_I; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00407; IGc1; 1.
SMART graphical view of domain structure.

PROSITE

PS50835; IG_LIKE; 1.
PS00290; IG_MHC; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSG00000204525; Homo sapiens. [Contig view]

Phylogenomic databases

HOVERGEN

P30480; -.

Other

SOURCE

HLA-B; Homo sapiens.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Glycoprotein; Host-virus interaction; Immune response; Membrane; MHC I; Polymorphism; Signal; Transmembrane; Ubl conjugation.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 24`	`24`
`CHAIN`	`25 362`	`338`	`HLA class I histocompatibility antigen, B-42 alpha chain.`	`PRO_0000018846`
`TOPO_DOM`	`25 309`	`285`	`Extracellular (Potential).`
`TRANSMEM`	`310 333`	`24`	`Potential.`
`TOPO_DOM`	`334 362`	`29`	`Cytoplasmic (Potential).`
`DOMAIN`	`209 295`	`87`	`Ig-like C1-type.`
`REGION`	`25 114`	`90`	`Alpha-1.`
`REGION`	`115 206`	`92`	`Alpha-2.`
`REGION`	`207 298`	`92`	`Alpha-3.`
`REGION`	`299 309`	`11`	`Connecting peptide.`
`CARBOHYD`	`110 110`		`N-linked (GlcNAc...) (By similarity).`
`DISULFID`	`125 188`		`By similarity.`
`DISULFID`	`227 283`		`By similarity.`
`VARIANT`	`33 33`	`1`	`Y -> H (in allele B*4202).`	`VAR_016460 [3D]`

Sequence information

Length: 362 AA [This is the length of the unprocessed precursor]

Molecular weight: 40333 Da [This is the MW of the unprocessed precursor]

CRC64: C9155AB015DEA1BE [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF 

        70         80         90        100        110        120 
DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ 

       130        140        150        160        170        180 
SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARVAEQD 

       190        200        210        220        230        240 
RAYLEGTCVE WLRRYLENGK DTLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 

       250        260        270        280        290        300 
WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 

       310        320        330        340        350        360 
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL 


TA

P30480 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools