[1]
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NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Oregon-R;
TISSUE=Head;
PubMed=1545235 [NCBI, ExPASy, EBI, Israel, Japan]
Hayflick J.S.,
Wolfgang W.J.,
Forte M.A.,
Thomas G.;
"A unique Kex2-like endoprotease from Drosophila melanogaster is expressed in the central nervous system during early embryogenesis.";
J. Neurosci. 12:705-717(1992).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
STRAIN=Oregon-R, and Tuebingen;
TISSUE=Embryo;
PubMed=8491178 [NCBI, ExPASy, EBI, Israel, Japan]
Roebroek A.J.M.,
Creemers J.W.M.,
Pauli I.G.L.,
Bogaert T.,
Van de Ven W.J.M.;
"Generation of structural and functional diversity in furin-like proteins in Drosophila melanogaster by alternative splicing of the DFur1 gene.";
EMBO J. 12:1853-1870(1993).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
DOI=10.1126/science.287.5461.2185; PubMed=10731132 [NCBI, ExPASy, EBI, Israel, Japan]
Adams M.D.,
Celniker S.E.,
Holt R.A.,
Evans C.A.,
Gocayne J.D.,
Amanatides P.G.,
Scherer S.E.,
Li P.W.,
Hoskins R.A.,
Galle R.F.,
George R.A.,
Lewis S.E.,
Richards S.,
Ashburner M.,
Henderson S.N.,
Sutton G.G.,
Wortman J.R.,
Yandell M.D.,
Zhang Q., ![]()
Chen L.X.,
Brandon R.C.,
Rogers Y.-H.C.,
Blazej R.G.,
Champe M.,
Pfeiffer B.D.,
Wan K.H.,
Doyle C.,
Baxter E.G.,
Helt G.,
Nelson C.R.,
Miklos G.L.G.,
Abril J.F.,
Agbayani A.,
An H.-J.,
Andrews-Pfannkoch C.,
Baldwin D.,
Ballew R.M.,
Basu A.,
Baxendale J.,
Bayraktaroglu L.,
Beasley E.M.,
Beeson K.Y.,
Benos P.V.,
Berman B.P.,
Bhandari D.,
Bolshakov S.,
Borkova D.,
Botchan M.R.,
Bouck J.,
Brokstein P.,
Brottier P.,
Burtis K.C.,
Busam D.A.,
Butler H.,
Cadieu E.,
Center A.,
Chandra I.,
Cherry J.M.,
Cawley S.,
Dahlke C.,
Davenport L.B.,
Davies P.,
de Pablos B.,
Delcher A.,
Deng Z.,
Mays A.D.,
Dew I.,
Dietz S.M.,
Dodson K.,
Doup L.E.,
Downes M.,
Dugan-Rocha S.,
Dunkov B.C.,
Dunn P.,
Durbin K.J.,
Evangelista C.C.,
Ferraz C.,
Ferriera S.,
Fleischmann W.,
Fosler C.,
Gabrielian A.E.,
Garg N.S.,
Gelbart W.M.,
Glasser K.,
Glodek A.,
Gong F.,
Gorrell J.H.,
Gu Z.,
Guan P.,
Harris M.,
Harris N.L.,
Harvey D.A.,
Heiman T.J.,
Hernandez J.R.,
Houck J.,
Hostin D.,
Houston K.A.,
Howland T.J.,
Wei M.-H.,
Ibegwam C.,
Jalali M.,
Kalush F.,
Karpen G.H.,
Ke Z.,
Kennison J.A.,
Ketchum K.A.,
Kimmel B.E.,
Kodira C.D.,
Kraft C.L.,
Kravitz S.,
Kulp D.,
Lai Z.,
Lasko P.,
Lei Y.,
Levitsky A.A.,
Li J.H.,
Li Z.,
Liang Y.,
Lin X.,
Liu X.,
Mattei B.,
McIntosh T.C.,
McLeod M.P.,
McPherson D.,
Merkulov G.,
Milshina N.V.,
Mobarry C.,
Morris J.,
Moshrefi A.,
Mount S.M.,
Moy M.,
Murphy B.,
Murphy L.,
Muzny D.M.,
Nelson D.L.,
Nelson D.R.,
Nelson K.A.,
Nixon K.,
Nusskern D.R.,
Pacleb J.M.,
Palazzolo M.,
Pittman G.S.,
Pan S.,
Pollard J.,
Puri V.,
Reese M.G.,
Reinert K.,
Remington K.,
Saunders R.D.C.,
Scheeler F.,
Shen H.,
Shue B.C.,
Siden-Kiamos I.,
Simpson M.,
Skupski M.P.,
Smith T.J.,
Spier E.,
Spradling A.C.,
Stapleton M.,
Strong R.,
Sun E.,
Svirskas R.,
Tector C.,
Turner R.,
Venter E.,
Wang A.H.,
Wang X.,
Wang Z.-Y.,
Wassarman D.A.,
Weinstock G.M.,
Weissenbach J.,
Williams S.M.,
Woodage T.,
Worley K.C.,
Wu D.,
Yang S.,
Yao Q.A.,
Ye J.,
Yeh R.-F.,
Zaveri J.S.,
Zhan M.,
Zhang G.,
Zhao Q.,
Zheng L.,
Zheng X.H.,
Zhong F.N.,
Zhong W.,
Zhou X.,
Zhu S.C.,
Zhu X.,
Smith H.O.,
Gibbs R.A.,
Myers E.W.,
Rubin G.M.,
Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
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[4]
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GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
PubMed=12537572 [NCBI, ExPASy, EBI, Israel, Japan]
Misra S.,
Crosby M.A.,
Mungall C.J.,
Matthews B.B.,
Campbell K.S.,
Hradecky P.,
Huang Y.,
Kaminker J.S.,
Millburn G.H.,
Prochnik S.E.,
Smith C.D.,
Tupy J.L.,
Whitfield E.J.,
Bayraktaroglu L.,
Berman B.P.,
Bettencourt B.R.,
Celniker S.E.,
de Grey A.D.N.J.,
Drysdale R.A., ![]()
Harris N.L.,
Richter J.,
Russo S.,
Schroeder A.J.,
Shu S.Q.,
Stapleton M.,
Yamada C.,
Ashburner M.,
Gelbart W.M.,
Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
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- FUNCTION: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif (By similarity).
- CATALYTIC ACTIVITY: Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein.
- ALTERNATIVE PRODUCTS:
4 named isoforms [FASTA] produced by alternative splicing.
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| Name | 1 |
| Synonyms | F |
| Isoform ID | P26016-2 |
| This isoform is stored in UniProtKB/Swiss-Prot entry P26016. |
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| Name | 1-X |
| Synonyms | E |
| Isoform ID | P26016-1 |
| This isoform is stored in UniProtKB/Swiss-Prot entry P26016. |
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| Name | 2 |
| Synonyms | C, D, F |
| Isoform ID | P26016-3 |
| This isoform is stored in UniProtKB/Swiss-Prot entry P26016. |
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- TISSUE SPECIFICITY: In adults, P26016-2'>isoform 1-CRR is expressed in CNS, fat body, and female reproductive tissues, and in embryos, in anal pads, hindgut, developing antennomaxillary complex, oenocytes, clipeolabrum, pharynx, trachea, CNS and developing posterior spiracles.
- DEVELOPMENTAL STAGE: P26016-2'>Isoform 1-CRR is expressed in embryos, larvae, pupae and adults.
- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily [view classification].
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