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UniProtKB/Swiss-Prot entry P30279


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CCND2_HUMAN
Primary accession number P30279
Secondary accession numbers Q13955 Q5U035
Integrated into Swiss-Prot on April 1, 1993
Sequence was last modified on April 1, 1993 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 84)
Name and origin of the protein
Protein name G1/S-specific cyclin-D2
Synonyms None
Gene name
Name: CCND2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0888-7543(92)90127-E; PubMed=1386336 [NCBI, ExPASy, EBI, Israel, Japan]
Xiong Y., Menninger J., Beach D., Ward D.C.;
"Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins.";
Genomics 13:575-584(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8455931 [NCBI, ExPASy, EBI, Israel, Japan]
Palmero I., Holder A., Sinclair A.J., Dickson C., Peters G.;
"Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines.";
Oncogene 8:1049-1054(1993).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Bone marrow;
Miyajima N.;
Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ARG-268.
Rieder M.J., Livingston R.J., Braun A.C., Montoya M.A., Chung M.-W., Miyamoto K.E., Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S., Sherwood J.K., Witrak L.A., Nickerson D.A.;
"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Bone marrow, and Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-240.
TISSUE=Placenta;
DOI=10.1016/0888-7543(92)90126-D; PubMed=1386335 [NCBI, ExPASy, EBI, Israel, Japan]
Inaba T., Matsushime H., Valentine M., Roussel M.F., Sherr C.J., Look A.T.;
"Genomic organization, chromosomal localization, and independent expression of human cyclin D genes.";
Genomics 13:565-574(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M90813; AAA51926.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X68452; CAA48493.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D13639; BAA02802.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT019847; AAV38650.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF518005; AAM54041.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC010958; AAH10958.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC089384; AAH89384.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M88083; AAA51928.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M88080; AAA51928.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M88081; AAA51928.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M88082; AAA51928.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A42822; A42822.
RefSeq NP_001750.1; -.
UniGene Hs.376071
3D structure databases
ModBase P30279.
Protein-protein interaction databases
DIP DIP:178N; -.
IntAct P30279; -.
PTM databases
PhosphoSite P30279; -.
Enzyme and pathway databases
Reactome REACT_152; Cell Cycle, Mitotic.
Polymorphism databases
NIEHS-SNPs CCND2.
Organism-specific databases
H-InvDB HIX0010346; -.
HGNC HGNC:1583; CCND2.
GenAtlas CCND2.
MIM 123833; gene. [NCBI / EBI]
PharmGKB PA26150; -.
GeneCards P30279.
Gene expression databases
ArrayExpress P30279; -.
CleanEx HS_CCND2; -.
GermOnline ENSG00000118971; Homo sapiens.
Ontologies
GO
GO:0000307; Cellular component: cyclin-dependent protein kinase holoenzyme complex (inferred from direct assay from UniProtKB).
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from InterPro).
GO:0019901; Molecular function: protein kinase binding (inferred from physical interaction from UniProtKB).
GO:0051301; Biological process: cell division (inferred from electronic annotation from UniProtKB-KW).
GO:0045737; Biological process: positive regulation of cyclin-dependent protein kinase activity (inferred from direct assay from UniProtKB).
GO:0001934; Biological process: positive regulation of protein amino acid phosphorylation (inferred from direct assay from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR015451; CycD.
IPR006670; Cyclin.
IPR014400; Cyclin_A_B_D_E.
IPR004367; Cyclin_C.
IPR006671; Cyclin_N.
IPR013763; Cyclin_related.
Graphical view of domain structure.
Gene3D G3DSA:1.10.472.10; Cyclin_related; 1.
PANTHER PTHR10177:SF12; CycD; 1.
Pfam PF02984; Cyclin_C; 1.
PF00134; Cyclin_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001771; Cyclin_A_B_D_E; 1.
SMART SM00385; CYCLIN; 1.
SMART graphical view of domain structure.
PROSITE PS00292; CYCLINS; 1.
BLOCKS P30279.
ProtoNet P30279.
Genome annotation databases
Ensembl ENSG00000118971; Homo sapiens. [Contig view]
GeneID 894; -.
KEGG hsa:894; -.
Phylogenomic databases
HOGENOM P30279; -.
HOVERGEN P30279; -.
Other
LinkHub P30279; -.
NextBio 3696; -.
SOURCE CCND2; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell cycle; Cell division; Cyclin; Polymorphism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   289  289     G1/S-specific cyclin-D2. PRO_0000080437
VARIANT   268   268  1     G -> R (in dbSNP:rs3217921 [NCBI]). VAR_018820 
CONFLICT   166   167        KL -> NV (in Ref. 7; AAA51928). 
CONFLICT   224   224        T -> H (in Ref. 7; AAA51928). 
Sequence information
Length: 289 AA [This is the length of the unprocessed precursor] Molecular weight: 33067 Da [This is the MW of the unprocessed precursor] CRC64: E4E5FEF476D76D90 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MELLCHEVDP VRRAVRDRNL LRDDRVLQNL LTIEERYLPQ CSYFKCVQKD IQPYMRRMVA 

        70         80         90        100        110        120 
TWMLEVCEEQ KCEEEVFPLA MNYLDRFLAG VPTPKSHLQL LGAVCMFLAS KLKETSPLTA 

       130        140        150        160        170        180 
EKLCIYTDNS IKPQELLEWE LVVLGKLKWN LAAVTPHDFI EHILRKLPQQ REKLSLIRKH 

       190        200        210        220        230        240 
AQTFIALCAT DFKFAMYPPS MIATGSVGAA ICGLQQDEEV SSLTCDALTE LLAKITNTDV 

       250        260        270        280 
DCLKACQEQI EAVLLNSLQQ YRQDQRDGSK SEDELDQAST PTDVRDIDL 

P30279 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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