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UniProtKB/Swiss-Prot entry P30201

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LYSC_MACMU
Primary accession number P30201
Secondary accession numbers None
Integrated into Swiss-Prot on April 1, 1993
Sequence was last modified on April 1, 1993 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 60)
Name and origin of the protein
Protein name Lysozyme C [Precursor]
Synonyms EC 3.2.1.17
1,4-beta-N-acetylmuramidase C
Gene name
Name: LYZ
From
Macaca mulatta (Rhesus macaque) [TaxID: 9544] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Mammary gland;
DOI=10.1007/BF02103133; PubMed=1960739 [NCBI, ExPASy, EBI, Israel, Japan]
Swanson K.W., Irwin D.M., Wilson A.C.;
"Stomach lysozyme gene of the langur monkey: tests for convergence and positive selection.";
J. Mol. Evol. 33:418-425(1991).
Comments
  • FUNCTION: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
  • CATALYTIC ACTIVITY: Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
  • SUBUNIT: Monomer.
  • MISCELLANEOUS: Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
  • SIMILARITY: Belongs to the glycosyl hydrolase 22 family [view classification].
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X60236; CAA42796.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001095203.1; -.
UniGene Mmu.1820
3D structure databases
HSSP P00695; 1C46. [HSSP ENTRY / PDB]
SMR P30201; 19-148.
ModBase P30201.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from InterPro).
GO:0003796; Molecular function: lysozyme activity (inferred from electronic annotation from InterPro).
GO:0016998; Biological process: cell wall catabolic process (inferred from electronic annotation from InterPro).
GO:0019835; Biological process: cytolysis (inferred from electronic annotation from UniProtKB-KW).
GO:0042742; Biological process: defense response to bacterium (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001916; Glyco_hydro_22.
IPR000974; Glyco_hydro_22_lys.
Graphical view of domain structure.
Pfam PF00062; Lys; 1.
Pfam graphical view of domain structure.
PRINTS PR00137; LYSOZYME.
PR00135; LYZLACT.
SMART SM00263; LYZ1; 1.
SMART graphical view of domain structure.
PROSITE PS00128; LACTALBUMIN_LYSOZYME_1; 1.
PS51348; LACTALBUMIN_LYSOZYME_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P30201.
ProtoNet P30201.
Genome annotation databases
Ensembl ENSMMUG00000008987; Macaca mulatta. [Contig view]
GeneID 718361; -.
KEGG mcc:718361; -.
Phylogenomic databases
HOVERGEN P30201; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Antimicrobial; Bacteriolytic enzyme; Glycosidase; Hydrolase; Milk protein; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
SIGNAL   1    18  18     By similarity. 
CHAIN   19   148  130     Lysozyme C. PRO_0000018470
ACT_SITE   53    53        By similarity. 
ACT_SITE   71    71        By similarity. 
DISULFID   24   146        By similarity. 
DISULFID   48   134        By similarity. 
DISULFID   83    99        By similarity. 
DISULFID   95   113        By similarity. 
Sequence information
Length: 148 AA [This is the length of the unprocessed precursor] Molecular weight: 16408 Da [This is the MW of the unprocessed precursor] CRC64: AF4EE1B3A33F4765 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKAVIILGLV LLSVTVQGKI FERCELARTL KRLGLDGYRG ISLANWVCLA KWESNYNTQA 

        70         80         90        100        110        120 
TNYNPGDQST DYGIFQINSH YWCNNGKTPG AVNACHISCN ALLQDNIADA VTCAKRVVSD 

       130        140 
PQGIRAWVAW RNHCQNRDVS QYVQGCGV
P30201 in FASTA format

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View entry in raw text format (no links)
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