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UniProtKB/Swiss-Prot entry P29837

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name POLG_LANVT
Primary accession number P29837
Secondary accession numbers None
Integrated into Swiss-Prot on April 1, 1993
Sequence was last modified on February 1, 1994 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 79)
Name and origin of the protein
Protein name Genome polyprotein
Synonyms None
Contains Protein C
     (Core protein)
     (Capsid protein)
Small envelope protein M
     (Matrix protein)
Envelope protein E
Non-structural protein 1
     (NS1)
Non-structural protein 2A
     (NS2A)
Flavivirin protease NS2B regulatory subunit
Flavivirin protease NS3 catalytic subunit
     (EC 3.4.21.91)
Non-structural protein 4A
     (NS4A)
Non-structural protein 4B
     (NS4B)
RNA-directed RNA polymerase
     (EC 2.7.7.48)
     (NS5)
Gene name None
From
Langat virus (strain TP21) [TaxID: 31638] 
Taxonomy Viruses; ssRNA positive-strand viruses, no DNA stage; Flaviviridae; Flavivirus; tick-borne encephalitis virus group.
Virus hosts Homo sapiens (Human) [TaxID: 9606]
Ixodida (ticks) [TaxID: 6935]
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE OF 1-776.
DOI=10.1016/0042-6822(91)90567-U; PubMed=1720591 [NCBI, ExPASy, EBI, Israel, Japan]
Mandl C.W., Iacono-Connors L., Wallner G., Holzmann H., Kunz C., Heinz F.X.;
"Sequence of the genes encoding the structural proteins of the low-virulence tick-borne flaviviruses Langat TP21 and Yelantsev.";
Virology 185:891-895(1991).
[2]
 NUCLEOTIDE SEQUENCE OF 777-3414.
DOI=10.1016/0042-6822(92)90545-Z; PubMed=1316684 [NCBI, ExPASy, EBI, Israel, Japan]
Iacono-Connors L.C., Schmaljohn C.S.;
"Cloning and sequence analysis of the genes encoding the nonstructural proteins of Langat virus and comparative analysis with other flaviviruses.";
Virology 188:875-880(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M73835; AAA02740.1; ALT_TERM; Unassigned_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S35365; AAB22165.1; -; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A42545; A42545.
3D structure databases
PDB
1Z66; NMR; -; A=580-675.[ExPASy / RCSB / EBI]
2GG1; NMR; -; A=580-675.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1Z66; -.
2GG1; -.
SMR P29837; 281-675.
ModBase P29837.
Protein family/group databases
MEROPS S07.001; -.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0019031; Cellular component: viral envelope (inferred from electronic annotation from InterPro).
GO:0019013; Cellular component: viral nucleocapsid (inferred from electronic annotation from UniProtKB-KW).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0008026; Molecular function: ATP-dependent helicase activity (inferred from electronic annotation from InterPro).
GO:0003725; Molecular function: double-stranded RNA binding (inferred from electronic annotation from InterPro).
GO:0003724; Molecular function: RNA helicase activity (inferred from electronic annotation from InterPro).
GO:0003968; Molecular function: RNA-directed RNA polymerase activity (inferred from electronic annotation from InterPro).
GO:0004252; Molecular function: serine-type endopeptidase activity (inferred from electronic annotation from InterPro).
GO:0005198; Molecular function: structural molecule activity (inferred from electronic annotation from InterPro).
GO:0016070; Biological process: RNA metabolic process (inferred from electronic annotation from InterPro).
GO:0006410; Biological process: transcription, RNA-dependent (inferred from electronic annotation from UniProtKB-KW).
GO:0019079; Biological process: viral genome replication (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR014001; DEAD-like_N.
IPR011492; DEAD_Flavivir.
IPR001650; DNA/RNA_helicase_C.
IPR002464; DNA/RNA_helicase_DEAH_CS.
IPR011999; Flav_glyE_cen_dm.
IPR013754; Flav_glyE_dim.
IPR001122; Flavi_capsidC.
IPR000069; Flavi_M.
IPR001157; Flavi_NS1.
IPR000752; Flavi_NS2A.
IPR000487; Flavi_NS2B.
IPR000404; Flavi_NS4A.
IPR001528; Flavi_NS4B.
IPR002535; Flavi_propep.
IPR000336; Flv_glyE_Ig-like.
IPR014412; Gen_Poly_FLV.
IPR014021; Helicase_SF1/SF2_ATP-bd.
IPR001850; Peptidase_S7.
IPR000208; RNA_pol_flaviviral.
IPR007094; RNA_pol_PSvir.
IPR002877; RrmJFtsJ_MeTrfase.
Graphical view of domain structure.
Gene3D G3DSA:2.60.98.10; Flav_glyE_dim; 1.
G3DSA:2.60.40.350; Flv_glyE_Ig-like; 1.
Pfam PF01003; Flavi_capsid; 1.
PF07652; Flavi_DEAD; 1.
PF02832; Flavi_glycop_C; 1.
PF00869; Flavi_glycoprot; 1.
PF01004; Flavi_M; 1.
PF00948; Flavi_NS1; 1.
PF01005; Flavi_NS2A; 1.
PF01002; Flavi_NS2B; 1.
PF01350; Flavi_NS4A; 1.
PF01349; Flavi_NS4B; 1.
PF00972; Flavi_NS5; 1.
PF01570; Flavi_propep; 1.
PF01728; FtsJ; 1.
PF00271; Helicase_C; 1.
PF00949; Peptidase_S7; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF003817; Gen_Poly_FLV; 1.
ProDom PD001496; Flavi_NS1; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00487; DEXDc; 1.
SM00490; HELICc; 1.
SMART graphical view of domain structure.
PROSITE PS00690; DEAH_ATP_HELICASE; FALSE_NEG.
PS51192; HELICASE_ATP_BIND_1; 1.
PS51194; HELICASE_CTER; 1.
PS50507; RDRP_SSRNA_POS; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P29837.
ProtoNet P29837.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; ATP-binding; Capsid protein; Cleavage on pair of basic residues; Complete proteome; Core protein; Envelope protein; Glycoprotein; Helicase; Hydrolase; Membrane; Nucleotide-binding; Nucleotidyltransferase; RNA replication; RNA-directed RNA polymerase; Transferase; Transmembrane; Virion.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
INIT_MET   1      1        Removed; by host. 
CHAIN   2    112  111     Protein C (Potential). PRO_0000037688
PROPEP   113    205  93      PRO_0000037689
CHAIN   206    280  75     Small envelope protein M (Potential). PRO_0000037690
CHAIN   281    776  496     Envelope protein E (Potential). PRO_0000037691
CHAIN   777   1128  352     Non-structural protein 1 (Potential). PRO_0000037692
CHAIN   1129   1358  230     Non-structural protein 2A (Potential). PRO_0000037693
CHAIN   1359   1489  131     Flavivirin protease NS2B regulatory subunit (Potential). PRO_0000037694
CHAIN   1490   2110  621     Flavivirin protease NS3 catalytic subunit (Potential). PRO_0000037695
CHAIN   2111   2259  149     Non-structural protein 4A (Potential). PRO_0000037696
CHAIN   2260   2511  252     Non-structural protein 4B (Potential). PRO_0000037697
CHAIN   2512   3414  903     RNA-directed RNA polymerase (Potential). PRO_0000037698
TRANSMEM   103    119  17     Potential. 
TRANSMEM   262    278  17     Potential. 
TRANSMEM   728    744  17     Potential. 
TRANSMEM   758    774  17     Potential. 
DOMAIN   1496   1672  177     Peptidase S7. 
DOMAIN   1675   1831  157     Helicase ATP-binding. 
DOMAIN   1841   2000  160     Helicase C-terminal. 
DOMAIN   3040   3189  150     RdRp catalytic. 
NP_BIND   1688   1695  8     ATP (Potential). 
MOTIF   1779   1782  4     DEAH box. 
ACT_SITE   1543   1543        Charge relay system (By similarity). 
ACT_SITE   1567   1567        Charge relay system (By similarity). 
ACT_SITE   1627   1627        Charge relay system (By similarity). 
CARBOHYD   144    144        N-linked (GlcNAc...) (Potential). 
CARBOHYD   434    434        N-linked (GlcNAc...) (Potential). 
DISULFID   283    310        By similarity. 
DISULFID   340    396        By similarity. 
DISULFID   354    385        By similarity. 
DISULFID   372    401        By similarity. 
DISULFID   466    570        By similarity. 
DISULFID   587    618        By similarity. 
STRAND   593    600  8      
STRAND   602    611  10      
STRAND   622    626  5      
STRAND   629    633  5      
STRAND   648    654  7      
STRAND   657    665  9      
STRAND   670    674  5      
Sequence information
Length: 3414 AA [This is the length of the unprocessed precursor] Molecular weight: 378023 Da [This is the MW of the unprocessed precursor] CRC64: 59CB7E95DD70D82E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAGKAVLKGK GGGPPRRASK VAPKKTRQLR VQMPNGLVLM RMLGVLWHAL TGTARSPVLK 

        70         80         90        100        110        120 
AFWKVVPLKQ ATLALRKIKR TVSTLMVGLH RRGSRRTTID WMTPLLITVM LGMCLTATVR 

       130        140        150        160        170        180 
RERDGSMVIR AEGRDAATQV RVENGTCVIL ATDMGSWCDD SLAYECVTID QGEEPVDVDC 

       190        200        210        220        230        240 
FCRGVEKVTL EYGRCGRREG SRSRRSVLIP SHAQRDLTGR GHQWLEGEAV KAHLTRVEGW 

       250        260        270        280        290        300 
VWKNKLFTLS LVMVAWLMVD GLLPRILIVV VALALVPAYA SRCTHLENRD FVTGVQGTTR 

       310        320        330        340        350        360 
LTLVLELGGC VTVTADGKPS LDVWLDSIYQ ESPAQTREYC LHAKLTGTKV AARCPTMGPA 

       370        380        390        400        410        420 
TLPEEHQSGT VCKRDQSDRG WGNHCGLFGK GSIVTCVKFT CEDKKKATGH VYDVNKITYT 

       430        440        450        460        470        480 
IKVEPHTGEF VAANETHSGR KSASFTVSSE KTILTLGDYG DVSLLCRVAS GVDLAQTVVL 

       490        500        510        520        530        540 
ALDKTHEHLP TAWQVHRDWF NDLALPWKHD GAEAWNEAGR LVEFGTPHAV KMDVFNLGDQ 

       550        560        570        580        590        600 
TGVLLKSLAG VPVASIEGTK YHLKSGHVTC EVGLEKLKMK GLTYTVCDKT KFTWKRAPTD 

       610        620        630        640        650        660 
SGHDTVVMEV GFSGTRPCRI PVRAVAHGVP EVNVAMLITP NPTMENNGGG FIEMQLPPGD 

       670        680        690        700        710        720 
NIIYVGDLNH QWFQKGSSIG RVLQKTRKGI ERLTVLGEHA WDFGSVGGVM TSIGRAMHTV 

       730        740        750        760        770        780 
LGGAFNTLLG GVGFLPKILL GVAMAWLGLN MRNPTLSMGF LLSGGLVLAM TLGVGADVGC 

       790        800        810        820        830        840 
AVDTERMELR CGEGLVVWRE VSEWYDNYVF HPETPAVLAS AVQRAYEEEI CGIVPQNRLE 

       850        860        870        880        890        900 
MAMWRSSLVE LNLALAEGEA NLTVVVDKAD PSDYRGGVPG LLNKGKDIKV SWRSWGRSML 

       910        920        930        940        950        960 
WSVPEAPRRF MIGVEGGREC PFARRKTGVM TVAEFGIGLR TKVFMDLRQE LTTECDTGVM 

       970        980        990       1000       1010       1020 
GAAVKNGMAV HTDQSLWMKS IKNDTTVTIV ELIVTDLRNC TWPASHTIDN AGVVNSKLFL 

      1030       1040       1050       1060       1070       1080 
PASLAGPRST YNVIPGYAEQ VRGPWAHTPV RIKREECPGT RVTIDKACDK RGASVRSTTE 

      1090       1100       1110       1120       1130       1140 
SGKVIPEWCC RTCELPPVTY RTGTDCWYAM EIRPVHTQGG LVRSMVVADN GALLSEGGVP 

      1150       1160       1170       1180       1190       1200 
GVVALFVVLE LVIRRRPATG GTVIWGGIAI LALLVTGLVS VESLFRYLVA VGLVFQLELG 

      1210       1220       1230       1240       1250       1260 
PEAVAMVLLQ AVFEMRTCLL SGFVLRRSIT TREIVTVYFL LLVLEMGIPV KGLEHLWRWT 

      1270       1280       1290       1300       1310       1320 
DALAMGAIIF RACTAEGKTG IGLLLAAFMT QSDMNIIHDG LTAFLCVATT MAIWRYIRGQ 

      1330       1340       1350       1360       1370       1380 
GERKGLTWIV PLAGILGGEG SGVRLLAFWE LAASRGRRSF NEPMTVIGVM LTLASGMMRH 

      1390       1400       1410       1420       1430       1440 
TSQEAVCAMA LAAFLLLMLT LGTRKMQLLA EWSGNIEWNP ELTSEGGEVS LRVRQDALGN 

      1450       1460       1470       1480       1490       1500 
LHLTELEKEE RMMAFWLVVG LIASAFHWSG ILIVMGLWTI SEMLGSPRRT DLVFSGCSEG 

      1510       1520       1530       1540       1550       1560 
RSDSRPLDVK NGVYRIYTPG LLWGQRQIGV GYGAKGVLHT MWHVTRGAAL LVDGVAVGPY 

      1570       1580       1590       1600       1610       1620 
WADVREDVVC YGGAWSLESR WRGETVQVHA FPPGRAHETH QCQPGELILE NGRKMGAIPI 

      1630       1640       1650       1660       1670       1680 
DLAKGTSGSP IMNSQGEVVG LYGNGLKTND TYVSSIAQGE VEKSRPNLPQ SVVGTGWTAK 

      1690       1700       1710       1720       1730       1740 
GQITVLDMHP GSGKTHRVLP ELIRQCVERR LRTLVLAPTR VVLREMERAL SGKNVRFHSP 

      1750       1760       1770       1780       1790       1800 
AVTEQHANGA IVDVMCHATY VNRRLLPQGR QNWEVAIMDE AHWTDPHSIA ARGHLYSLAK 

      1810       1820       1830       1840       1850       1860 
ENRCAFVLMT ATPPGKSEPF PESNGAIASE ERQIPDGEWR DGFDWITEYE GRTAWFVPSI 

      1870       1880       1890       1900       1910       1920 
ARGGAIARAL RQRGKSVICL NSKTFDKEYS RVKDEKPDFV VTTDISEMGA NLDVTRVIDG 

      1930       1940       1950       1960       1970       1980 
RTNIKPEEVD GRIELTGTRR VTTASAAQRR GRVGRQGGRT DEYIYSGQCD DDDSGLVQWK 

      1990       2000       2010       2020       2030       2040 
EAQILLDNIT TARGPVATFY GPEQERMTET AGHYRLPEEK RKHFRHLLAQ CDFTPWLAWH 

      2050       2060       2070       2080       2090       2100 
VAANVASVTD RSWTWEGPEE NAVDENNGEL VTFRSPNGAE RTLRPVWRDA RMFREGRDIR 

      2110       2120       2130       2140       2150       2160 
EFVSYASGRR SVGDVLMGMS GVPALLRQRC TSAMDVFYTL MHEEPGSRAM RIGERDAPEA 

      2170       2180       2190       2200       2210       2220 
FLTAVEMLVL GLATLGVVWC FVVRTSVSRM VLGTLVLATS LIFLWAGGVG YGNMAGVALV 

      2230       2240       2250       2260       2270       2280 
FYTLLTVLQP ETGKQRSSDD NKLAYFLLTL CGLAGMVAAN EMGLLEKTKA DLAALFARDQ 

      2290       2300       2310       2320       2330       2340 
GETVRWGEWT NLDIQPARSW GTYVLVVSLF TPYMLHQLQT RIQQLVNSAV ASGAQAMRDL 

      2350       2360       2370       2380       2390       2400 
GGGTPFFGVA GHVLALGVAS LVGATPTSLI LGVGLAAFHL AIVVSGLEAE LTQRAHKVFF 

      2410       2420       2430       2440       2450       2460 
SAMVRNPMVD GDVINPFGDG EAKPALYERK LSLILALVLC LASVVMNRTF VAVTEAGAVG 

      2470       2480       2490       2500       2510       2520 
VAAAMQLLRP EMDVLWTMPV ACGMSGVVRG SLWGLLPLGH RLWLRTTGTR RGGSEGDTLG 

      2530       2540       2550       2560       2570       2580 
DMWKARLNSC TKEEFFAYRR AGVMETDREK ARELLKRGET NMGLAVSRGT SKLAWMEERG 

      2590       2600       2610       2620       2630       2640 
YVTLKGEVVD LGCGRGGWSY YAASRPAVMS VRAYTIGGKG HESPRMVTSL GWNLIKFRAG 

      2650       2660       2670       2680       2690       2700 
MDVFSMEPHR ADAILCDIGE SNPDAVVEGE RSRRVILLME QWKNRNPTAT CVFKVLAPYR 

      2710       2720       2730       2740       2750       2760 
PEVIEALHRF QLQWGGGLVR TPFSRNSTHE MYFSTAITGN IVNSVNIQSR KLLARFGDQR 

      2770       2780       2790       2800       2810       2820 
GPTRVPEIDL GVGTRSVVLA EDKVKEKDVM ERIQALKDQY CDTWHEDHEH PYRTWQYWGS 

      2830       2840       2850       2860       2870       2880 
YKTAATGSSA SLLNGVVKLL SWPWNAREDV VRMAMTDTTA FGQQRVFKDK VDTKAQEPQP 

      2890       2900       2910       2920       2930       2940 
GTKIIMRAVN DWLLERLVKK SRPRMCSREE FIAKVRSNAA LAAWSDEQNK WKSAREAVED 

      2950       2960       2970       2980       2990       3000 
PEFWSLVEAE RERHLQGRCA HCVYNMMGKR EKKLGEFGVA KGSRAIWYMW LGSRFLEFEA 

      3010       3020       3030       3040       3050       3060 
LGFLNEDHWA SRASSGAGVE GISLNYLGWH LKKLASLSGG LFYADDTAGW DTRITNADLD 

      3070       3080       3090       3100       3110       3120 
DEEQILRYMD GDHKKLAATV LRKAYHAKVV RVARPSREGG CVMDIITRRD QRGSGQVVTY 

      3130       3140       3150       3160       3170       3180 
ALNTITNIKV QLVRMMEGEG VIEVADSHNP RLLRVEKCVE EHGEERLSRM LVSGDDCVVR 

      3190       3200       3210       3220       3230       3240 
PVDDRFSKAL YFLNDMAKTR KDTGEWEPST GFASWEEVPF CSHHFHELVM KDGRALVVPC 

      3250       3260       3270       3280       3290       3300 
RDQDELVGRA RVSPGCGWSV RETACLSKAY GQMWLLSYFH RRDLRTLGFA ICSAVPVDWV 

      3310       3320       3330       3340       3350       3360 
PTGRTTWSIH ASGAWMTTED MLEVWNRVWI YDNPFMEDKT RVDEWRDTPY LPKSQDILCS 

      3370       3380       3390       3400       3410 
SLVGRGERAE WAKNIWGAVE KVRRMIGPEH YRDYLSSMDR HDLHWELKLE SSIF
P29837 in FASTA format

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