ID   AADB2_KLEPN             Reviewed;         177 AA.
AC   P29806;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   04-NOV-2008, entry version 33.
DE   RecName: Full=2''-aminoglycoside nucleotidyltransferase;
DE            EC=2.7.7.46;
DE   AltName: Full=AAD(2'');
DE   AltName: Full=Gentamicin 2''-nucleotidyltransferase;
DE   AltName: Full=Gentamicin resistance protein;
GN   Name=aadB;
OS   Klebsiella pneumoniae.
OG   Plasmid pLST1000.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Zieg J., Jiang H., McCabe F., O'Brien T.;
RL   Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This enzyme confers resistance to kanamycin, gentamicin,
CC       dibekacin, sisomicin, neomycin and tobramycin by adenylating the
CC       2''-hydroxyl group of these antibiotics.
CC   -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + gentamicin =
CC       diphosphate + 2''-nucleotidylgentamicin.
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DR   EMBL; X64369; CAA45722.1; -; Genomic_DNA.
DR   PIR; S19940; XNKBLS.
DR   GO; GO:0008871; F:aminoglycoside 2''-nucleotidyltransferase a...; IEA:EC.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   Antibiotic resistance; Nucleotidyltransferase; Plasmid; Transferase.
FT   CHAIN         1    177       2''-aminoglycoside
FT                                nucleotidyltransferase.
FT                                /FTId=PRO_0000068558.
SQ   SEQUENCE   177 AA;  19861 MW;  F941A0785D77E719 CRC64;
     MDTTQVTLIH QILAAADERN LPLWIGGGWA IDARLGRVTR KHDDIDLTFP GERRGELEAM
     VEMLGGRVTE ELDYGFLAEI GDELLDCEPA WWADEAYEIA EAPQGSCPEA AEGVIAGRPV
     RCNSWEAIIW DYFYYADEVP PVDWPTKHIE SYRLACTSLG AEKVEVLRAA FRSRYAA
//