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UniProtKB/Swiss-Prot entry P29806

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AADB2_KLEPN
Primary accession number P29806
Secondary accession numbers None
Integrated into Swiss-Prot on April 1, 1993
Sequence was last modified on April 1, 1993 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 33)
Name and origin of the protein
Protein name 2''-aminoglycoside nucleotidyltransferase
Synonyms EC 2.7.7.46
AAD(2'')
Gentamicin 2''-nucleotidyltransferase
Gentamicin resistance protein
Gene name
Name: aadB
From
Klebsiella pneumoniae [TaxID: 573] 
Encoded on Plasmid pLST1000.
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Klebsiella.
Protein existence 4: Predicted;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Zieg J., Jiang H., McCabe F., O'Brien T.;
Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases.
Comments
  • FUNCTION: This enzyme confers resistance to kanamycin, gentamicin, dibekacin, sisomicin, neomycin and tobramycin by adenylating the 2''-hydroxyl group of these antibiotics.
  • CATALYTIC ACTIVITY: Nucleoside triphosphate + gentamicin = diphosphate + 2''-nucleotidylgentamicin.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X64369; CAA45722.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S19940; XNKBLS.
3D structure databases
ModBase P29806.
Ontologies
GO
GO:0008871; Molecular function: aminoglycoside 2''-nucleotidyltransferase activity (inferred from electronic annotation from EC).
GO:0046677; Biological process: response to antibiotic (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
BLOCKS P29806.
ProtoNet P29806.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Antibiotic resistance; Nucleotidyltransferase; Plasmid; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   177  177     2''-aminoglycoside nucleotidyltransferase. PRO_0000068558
Sequence information
Length: 177 AA [This is the length of the unprocessed precursor] Molecular weight: 19861 Da [This is the MW of the unprocessed precursor] CRC64: F941A0785D77E719 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDTTQVTLIH QILAAADERN LPLWIGGGWA IDARLGRVTR KHDDIDLTFP GERRGELEAM 

        70         80         90        100        110        120 
VEMLGGRVTE ELDYGFLAEI GDELLDCEPA WWADEAYEIA EAPQGSCPEA AEGVIAGRPV 

       130        140        150        160        170 
RCNSWEAIIW DYFYYADEVP PVDWPTKHIE SYRLACTSLG AEKVEVLRAA FRSRYAA
P29806 in FASTA format

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