[1]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1378626 [NCBI, ExPASy, EBI, Israel, Japan]
Lamas S.,
Marsden P.A.,
Li G.K.,
Tempst P.,
Michel T.;
"Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.";
Proc. Natl. Acad. Sci. U.S.A. 89:6348-6352(1992).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1385480 [NCBI, ExPASy, EBI, Israel, Japan]
Nishida K.,
Harrison D.G.,
Navas J.P.,
Fisher A.A.,
Dockery S.P.,
Uematsu M.,
Nerem R.M.,
Alexander R.W.,
Murphy T.J.;
"Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.";
J. Clin. Invest. 90:2092-2096(1992).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Aortic endothelium;
PubMed=1379225 [NCBI, ExPASy, EBI, Israel, Japan]
Sessa W.C.,
Harrison J.K.,
Barber C.M.,
Zeng D.,
Durieux M.E.,
D'Angelo D.D.,
Lynch K.R.,
Peach M.J.;
"Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.";
J. Biol. Chem. 267:15274-15276(1992).
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[4]
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MYRISTOYLATION AT GLY-2.
PubMed=7682550 [NCBI, ExPASy, EBI, Israel, Japan]
Busconi L.,
Michel T.;
"Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization.";
J. Biol. Chem. 268:8410-8413(1993).
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[5]
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PALMITOYLATION AT CYS-15 AND CYS-26.
PubMed=8524847 [NCBI, ExPASy, EBI, Israel, Japan]
Robinson L.J.,
Michel T.;
"Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subcellular targeting.";
Proc. Natl. Acad. Sci. U.S.A. 92:11776-11780(1995).
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[6]
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PHOSPHORYLATION AT THR-497; SER-635 AND SER-1179.
DOI=10.1152/ajpheart.00214.2002; PubMed=12384459 [NCBI, ExPASy, EBI, Israel, Japan]
Boo Y.C.,
Hwang J.,
Sykes M.,
Michell B.J.,
Kemp B.E.,
Lum H.,
Jo H.;
"Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanism.";
Am. J. Physiol. 283:H1819-H1828(2002).
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[7]
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SUBCELLULAR LOCATION.
DOI=10.1152/ajpheart.00990.2006; PubMed=17071725 [NCBI, ExPASy, EBI, Israel, Japan]
Mukhopadhyay S.,
Xu F.,
Sehgal P.B.;
"Aberrant cytoplasmic sequestration of eNOS in endothelial cells after monocrotaline, hypoxia, and senescence: live-cell caveolar and cytoplasmic NO imaging.";
Am. J. Physiol. 292:H1373-H1389(2007).
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[8]
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X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 67-482.
DOI=10.1016/S0092-8674(00)81718-3; PubMed=9875848 [NCBI, ExPASy, EBI, Israel, Japan]
Raman C.S.,
Li H.,
Martasek P.,
Kral V.,
Masters B.S.S.,
Poulos T.L.;
"Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center.";
Cell 95:939-950(1998).
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[9]
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X-RAY CRYSTALLOGRAPHY (1.86 ANGSTROMS) OF 67-482.
DOI=10.1016/S0162-0134(00)00099-4; PubMed=11051558 [NCBI, ExPASy, EBI, Israel, Japan]
Li H.,
Raman C.S.,
Martasek P.,
Kral V.,
Masters B.S.S.,
Poulos T.L.;
"Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas.";
J. Inorg. Biochem. 81:133-139(2000).
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[10]
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X-RAY CRYSTALLOGRAPHY (1.93 ANGSTROMS).
DOI=10.1021/bi002658v; PubMed=11331003 [NCBI, ExPASy, EBI, Israel, Japan]
Li H.,
Raman C.S.,
Martasek P.,
Masters B.S.S.,
Poulos T.L.;
"Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors.";
Biochemistry 40:5399-5406(2001).
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[11]
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X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS).
DOI=10.1021/bi010957u; PubMed=11695891 [NCBI, ExPASy, EBI, Israel, Japan]
Raman C.S.,
Li H.,
Martasek P.,
Southan G.,
Masters B.S.S.,
Poulos T.L.;
"Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism.";
Biochemistry 40:13448-13455(2001).
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[12]
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X-RAY CRYSTALLOGRAPHY (1.93 ANGSTROMS).
DOI=10.1074/jbc.M102255200; PubMed=11331290 [NCBI, ExPASy, EBI, Israel, Japan]
Raman C.S.,
Li H.,
Martasek P.,
Babu B.R.,
Griffith O.W.,
Southan G.,
Masters B.S.S.,
Poulos T.L.;
"Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase.";
J. Biol. Chem. 276:26486-26491(2001).
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[13]
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X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
DOI=10.1074/jbc.M011469200; PubMed=11590164 [NCBI, ExPASy, EBI, Israel, Japan]
Kotsonis P.,
Frohlich L.G.,
Raman C.S.,
Li H.,
Berg M.,
Gerwig R.,
Groehn V.,
Kang Y.,
Al-Masoudi N.,
Taghavi-Moghadam S.,
Mohr D.,
Munch U.,
Schnabel J.,
Martasek P.,
Masters B.S.S.,
Strobel H.,
Poulos T.,
Matter H.,
Pfleiderer W.,
Schmidt H.H.H.W.;
"Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin.";
J. Biol. Chem. 276:49133-49141(2001).
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