[1]	NUCLEOTIDE SEQUENCE [MRNA]. PubMed=8468325 [NCBI, ExPASy, EBI, Israel, Japan] Tanabe T., Yamada M., Noma T., Kajii T., Nakazawa A.; "Tissue-specific and developmentally regulated expression of the genes encoding adenylate kinase isozymes."; J. Biochem. 113:200-207(1993).

Comments

FUNCTION: This small ubiquitous enzyme is essential for maintenance and cell growth.
CATALYTIC ACTIVITY: ATP + AMP = 2 ADP.
SUBUNIT: Monomer.
SUBCELLULAR LOCATION: Mitochondrion intermembrane space.
SIMILARITY: Belongs to the adenylate kinase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

D13061; BAA02378.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

JQ1944; JQ1944.

NP_112248.1; -.

3D structure databases

HSSP

P08166; 1AK2. [HSSP ENTRY / PDB]

SMR

P29410; 15-232.

ModBase

P29410.

Organism-specific databases

RGD

2077; Ak2.

Gene expression databases

GermOnline

ENSRNOG00000000122; Rattus norvegicus.

Ontologies

GO:0005758;	Cellular component: mitochondrial intermembrane space (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004017;	Molecular function: adenylate kinase activity (inferred from electronic annotation from InterPro).
GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0006139;	Biological process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR006259; Adenyl_kin_sub.
IPR000850; Adenylate_kin.
IPR007862; Adenylate_kinase_Znf_lid.
Graphical view of domain structure.

PANTHER

PTHR23359; Adenylate_kin; 1.

Pfam

PF00406; ADK; 1.
PF05191; ADK_lid; 1.
Pfam graphical view of domain structure.

PRINTS

PR00094; ADENYLTKNASE.

ProDom

PD000657; Adenylate_kin; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR01351; adk; 1.

PROSITE

PS00113; ADENYLATE_KINASE; 1.

Genome annotation databases

Ensembl

ENSRNOG00000000122; Rattus norvegicus. [Contig view]

GeneID

24184; -.

Phylogenomic databases

HOVERGEN

P29410; -.

Other

NextBio

602539; -.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Acetylation; ATP-binding; Kinase; Mitochondrion; Nucleotide-binding; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 239`	`238`	`Adenylate kinase isoenzyme 2, mitochondrial.`	`PRO_0000158920`
`NP_BIND`	`22 30`	`9`	`ATP (By similarity).`
`MOD_RES`	`93 93`		`N6-acetyllysine (By similarity).`

Sequence information

Length: 239 AA [This is the length of the unprocessed precursor]

Molecular weight: 26379 Da [This is the MW of the unprocessed precursor]

CRC64: 075A4ACBD581DB8C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAPNALAPEP EHPEGIRAVL LGPPGAGKGT QAPKLAENFC VCHLATGDML RAMVASGSEL 

        70         80         90        100        110        120 
GKKLKATMDA GKLVSDEMVV ELIEKNLETP SCKNGFLLDG FPRTVKQAEM LDDLMDKRKE 

       130        140        150        160        170        180 
KLDSVIEFSI QDSLLIRRIT GRLIHPKSGR SYHEEFNPPK EAMKDDITGE PLIRRSDDNE 

       190        200        210        220        230 
KALKTRLEAY HTQTTPLVEY YRKRGIHCAI DASQTPDVVF ASILAAFSKA TCKDLVMFV

P29410 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools