[1]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2319135 [NCBI, ExPASy, EBI, Israel, Japan]
Jackson D.G.,
Bell J.I.;
"Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation.";
J. Immunol. 144:2811-2815(1990).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, AND TISSUE SPECIFICITY.
TISSUE=Oesophageal carcinoma, and Pancreas;
DOI=10.1016/S0378-1119(96)00723-8; PubMed=9074508 [NCBI, ExPASy, EBI, Israel, Japan]
Nata K.,
Takamura T.,
Karasawa T.,
Kumagai T.,
Hashioka W.,
Tohgo A.,
Yonekura H.,
Takasawa S.,
Nakamura S.,
Okamoto H.;
"Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing.";
Gene 186:285-292(1997).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=B-cell;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[4]
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SIMILARITY TO NADASE.
DOI=10.1016/0968-0004(92)90337-9; PubMed=1471258 [NCBI, ExPASy, EBI, Israel, Japan]
States D.J.,
Walseth T.F.,
Lee H.C.;
"Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38.";
Trends Biochem. Sci. 17:495-495(1992).
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[5]
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CHARACTERIZATION.
PubMed=8253715 [NCBI, ExPASy, EBI, Israel, Japan]
Takasawa S.,
Tohgo A.,
Noguchi N.,
Koguma T.,
Nata K.,
Sugimoto T.,
Yonekura H.,
Okamoto H.;
"Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP.";
J. Biol. Chem. 268:26052-26054(1993).
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[6]
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ACTIVE SITE.
PubMed=7961800 [NCBI, ExPASy, EBI, Israel, Japan]
Tohgo A.,
Takasawa S.,
Noguchi N.,
Koguma T.,
Nata K.,
Sugimoto T.,
Furuya Y.,
Yonekura H.,
Okamoto H.;
"Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38.";
J. Biol. Chem. 269:28555-28557(1994).
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[7]
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SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
DOI=10.1186/gb-2004-5-2-r8; PubMed=14759258 [NCBI, ExPASy, EBI, Israel, Japan]
Hillman R.T.,
Green R.E.,
Brenner S.E.;
"An unappreciated role for RNA surveillance.";
Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).
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[8]
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X-RAY CRYSTALLOGRAPHY (1.91 ANGSTROMS) OF 45-300, AND DISULFIDE BONDS.
DOI=10.1016/j.str.2005.05.012; PubMed=16154090 [NCBI, ExPASy, EBI, Israel, Japan]
Liu Q.,
Kriksunov I.A.,
Graeff R.,
Munshi C.,
Lee H.C.,
Hao Q.;
"Crystal structure of human CD38 extracellular domain.";
Structure 13:1331-1339(2005).
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[9]
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VARIANT TRP-140.
DOI=10.1007/s001250051026; PubMed=9754820 [NCBI, ExPASy, EBI, Israel, Japan]
Yagui K.,
Shimada F.,
Mimura M.,
Hashimoto N.,
Suzuki Y.,
Tokuyama Y.,
Nata K.,
Tohgo A.,
Ikehata F.,
Takasawa S.,
Okamoto H.,
Makino H.,
Saito Y.,
Kanatsuka A.;
"A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro.";
Diabetologia 41:1024-1028(1998).
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- FUNCTION: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
- CATALYTIC ACTIVITY: NAD+ + H2O = ADP-ribose + nicotinamide.
- ENZYME REGULATION: ATP inhibits the hydrolyzing activity.
- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Isoform ID | P28907-2 |
| Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. |
| Features which should be applied to build the isoform sequence: VSP_000707, VSP_000708. |
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- TISSUE SPECIFICITY: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
- DEVELOPMENTAL STAGE: Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.
- SIMILARITY: Belongs to the ADP-ribosyl cyclase family.
- WEB RESOURCE: Name=Wikipedia; Note=CD38 entry; URL="http://en.wikipedia.org/wiki/CD38";.
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