ID   HN_SV5CP                Reviewed;         565 AA.
AC   P28884;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-NOV-2008, entry version 51.
DE   RecName: Full=Hemagglutinin-neuraminidase;
DE            EC=3.2.1.18;
GN   Name=HN;
OS   Simian virus 5 (isolate Canine/CPI+) (SV5).
OC   Viruses; ssRNA negative-strand viruses; Mononegavirales;
OC   Paramyxoviridae; Paramyxovirinae; Rubulavirus.
OX   NCBI_TaxID=31608;
OH   NCBI_TaxID=9615; Canis familiaris (Dog).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9541; Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
OH   NCBI_TaxID=9544; Macaca mulatta (Rhesus macaque).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=92113554; PubMed=1765772;
RA   Baty D.U., Southern J.A., Randall R.E.;
RT   "Sequence comparison between the haemagglutinin-neuraminidase genes of
RT   simian, canine and human isolates of simian virus 5.";
RL   J. Gen. Virol. 72:3103-3107(1991).
CC   -!- FUNCTION: Attaches the virus to sialic acid-containing cell
CC       receptors and thereby initiating infection. Binding of HN protein
CC       to the receptor induces a conformational change that allows the F
CC       protein to trigger virion/cell membranes fusion (By similarity).
CC   -!- FUNCTION: Neuraminidase activity ensures the efficient spread of
CC       the virus by dissociating the mature virions from the neuraminic
CC       acid containing glycoproteins (By similarity).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-,
CC       alpha-(2->8)- glycosidic linkages of terminal sialic acid residues
CC       in oligosaccharides, glycoproteins, glycolipids, colominic acid
CC       and synthetic substrates.
CC   -!- SUBCELLULAR LOCATION: Virion membrane; Single-pass type II
CC       membrane protein (Potential). Cell membrane; Single-pass type II
CC       membrane protein (Potential).
CC   -!- SIMILARITY: Belongs to the paramyxoviruses hemagglutinin-
CC       neuraminidase family.
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DR   PIR; JQ1306; HNNZC2.
DR   SMR; P28884; 118-565.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR   GO; GO:0019058; P:viral infectious cycle; IEA:InterPro.
DR   InterPro; IPR000665; Hemagglutn-neuramid_glycoprot.
DR   InterPro; IPR016285; Hemagglutn-neuramid_paramyxo.
DR   Pfam; PF00423; HN; 1.
DR   PIRSF; PIRSF001072; Hemagglut-neuramid_paramyxoV; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Envelope protein; Glycoprotein; Hemagglutinin;
KW   Hydrolase; Membrane; Signal-anchor; Transmembrane; Virion.
FT   CHAIN         1    565       Hemagglutinin-neuraminidase.
FT                                /FTId=PRO_0000142643.
FT   TOPO_DOM      1     20       Cytoplasmic (Potential).
FT   TRANSMEM     21     41       Potential.
FT   TOPO_DOM     42    565       Extracellular (Potential).
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    139    139       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    267    267       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    504    504       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   565 AA;  62307 MW;  4DA94276AC6F523C CRC64;
     MVAEDAPVRG TCRVLFRTTT LIFLCTLLAL SISILYESLI IRKQIMSQAG STGSNFRLGS
     ITDLLNNILS VANQIIYNSA VALPLQLDTL ESTLLTAIKS LQTSDKLEQN CSWGAALIND
     NRYINGINQF YFSIAEGRNL TLGPLLNIPS FIPTATTPEG CTRIPSFSLT KTHWCYTHNV
     ILNGCQDHVS SNQFVSMGII EPTSAGFPSF RTLKTLYLSD GVNRKSCSIS TVPGGCMMYC
     FVSTQPERDD YLSTAPPEQR IIIMYYNDTI VERIINPPGV LDVWATLNPG TGSGVYYLGW
     VLFPTYGGVI KDTSLWNNQA NKYFIPQMVA ALCSQNQATQ VQNAKSSYYS SWFGNRMIQS
     GILACPLQQD LTNECLILPF SNDQVLMGAE GRLYMYGDSV YYYQRSNSWW PMTMLYKVTI
     TFTNGQPSAI SAQNVPTQQV PRPGTGDCSA TNRCPGFCLK GVYADAWLLT NPSSTSTFGS
     EATFTGSYLN AATQRINPTM YIANNTQIIS SQQFGSSGQE AAYGHTTCFR DTGSVMVYCI
     YIIELSSSLL GQFQIVPFIR QVTLS
//