Canis familiaris (Dog) [TaxID: 9615]
Homo sapiens (Human) [TaxID: 9606]
Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) [TaxID: 9541]
Macaca mulatta (Rhesus macaque) [TaxID: 9544]

Protein existence

3: Inferred from homology;

References

[1]	NUCLEOTIDE SEQUENCE. PubMed=1765772 [NCBI, ExPASy, EBI, Israel, Japan] Baty D.U., Southern J.A., Randall R.E.; "Sequence comparison between the haemagglutinin-neuraminidase genes of simian, canine and human isolates of simian virus 5."; J. Gen. Virol. 72:3103-3107(1991).

Comments

FUNCTION: Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).
FUNCTION: Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity).
CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
SUBCELLULAR LOCATION: Virion membrane; Single-pass type II membrane protein (Potential). Cell membrane; Single-pass type II membrane protein (Potential).
SIMILARITY: Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

PIR

JQ1306; HNNZC2.

3D structure databases

SMR

P28884; 118-565.

ModBase

P28884.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0019031;	Cellular component: viral envelope (inferred from electronic annotation from InterPro).
GO:0055036;	Cellular component: virion membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004308;	Molecular function: exo-alpha-sialidase activity (inferred from electronic annotation from InterPro).
GO:0046789;	Molecular function: host cell surface receptor binding (inferred from electronic annotation from InterPro).
GO:0019058;	Biological process: viral infectious cycle (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR000665; Hemagglutn-neuramid_glycoprot.
IPR016285; Hemagglutn-neuramid_paramyxo.
Graphical view of domain structure.

Pfam

PF00423; HN; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF001072; Hemagglut-neuramid_paramyxoV; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; Envelope protein; Glycoprotein; Hemagglutinin; Hydrolase; Membrane; Signal-anchor; Transmembrane; Virion.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 565`	`565`	`Hemagglutinin-neuraminidase.`	`PRO_0000142643`
`TOPO_DOM`	`1 20`	`20`	`Cytoplasmic (Potential).`
`TRANSMEM`	`21 41`	`21`	`Potential.`
`TOPO_DOM`	`42 565`	`524`	`Extracellular (Potential).`
`CARBOHYD`	`110 110`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`139 139`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`267 267`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`504 504`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 565 AA [This is the length of the unprocessed precursor]

Molecular weight: 62307 Da [This is the MW of the unprocessed precursor]

CRC64: 4DA94276AC6F523C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MVAEDAPVRG TCRVLFRTTT LIFLCTLLAL SISILYESLI IRKQIMSQAG STGSNFRLGS 

        70         80         90        100        110        120 
ITDLLNNILS VANQIIYNSA VALPLQLDTL ESTLLTAIKS LQTSDKLEQN CSWGAALIND 

       130        140        150        160        170        180 
NRYINGINQF YFSIAEGRNL TLGPLLNIPS FIPTATTPEG CTRIPSFSLT KTHWCYTHNV 

       190        200        210        220        230        240 
ILNGCQDHVS SNQFVSMGII EPTSAGFPSF RTLKTLYLSD GVNRKSCSIS TVPGGCMMYC 

       250        260        270        280        290        300 
FVSTQPERDD YLSTAPPEQR IIIMYYNDTI VERIINPPGV LDVWATLNPG TGSGVYYLGW 

       310        320        330        340        350        360 
VLFPTYGGVI KDTSLWNNQA NKYFIPQMVA ALCSQNQATQ VQNAKSSYYS SWFGNRMIQS 

       370        380        390        400        410        420 
GILACPLQQD LTNECLILPF SNDQVLMGAE GRLYMYGDSV YYYQRSNSWW PMTMLYKVTI 

       430        440        450        460        470        480 
TFTNGQPSAI SAQNVPTQQV PRPGTGDCSA TNRCPGFCLK GVYADAWLLT NPSSTSTFGS 

       490        500        510        520        530        540 
EATFTGSYLN AATQRINPTM YIANNTQIIS SQQFGSSGQE AAYGHTTCFR DTGSVMVYCI 

       550        560 
YIIELSSSLL GQFQIVPFIR QVTLS

P28884 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools