|
|
|
|
|
|
[1]
|
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=NMRI;
TISSUE=Calvaria;
DOI=10.1016/0378-1119(92)90116-7; PubMed=1398148 [NCBI, ExPASy, EBI, Israel, Japan]
Hammani K.,
Henriet P.,
Eeckhout Y.;
"Cloning and sequencing of a cDNA encoding mouse stromelysin 1.";
Gene 120:321-322(1992).
|
[2]
|
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Swiss;
Li F.,
Strange R.,
Saurer S.,
Niemann H.,
Friis R.R.;
Submitted (AUG-1991) to the EMBL/GenBank/DDBJ databases.
|
[3]
|
NUCLEOTIDE SEQUENCE [MRNA] OF 415-469, AND DEVELOPMENTAL STAGE.
PubMed=2744464 [NCBI, ExPASy, EBI, Israel, Japan]
Brenner C.A.,
Adler R.R.,
Rappolee D.A.,
Pedersen R.A.,
Werb Z.;
"Genes for extracellular-matrix-degrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammalian development.";
Genes Dev. 3:848-859(1989).
|
|
|
|
- FUNCTION: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
- CATALYTIC ACTIVITY: Preferential cleavage where P1', P2' and P3' are hydrophobic residues.
- COFACTOR: Binds 4 calcium ions per subunit (By similarity).
- COFACTOR: Binds 2 zinc ions per subunit (By similarity).
- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (Probable).
- DEVELOPMENTAL STAGE: Present in unfertilized eggs and at the zygote and cleavage stages. Levels increase at the blastocyst stage and with endoderm differentiation.
- DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
- SIMILARITY: Belongs to the peptidase M10A family [view classification].
- SIMILARITY: Contains 4 hemopexin-like domains.
|
|
|
|
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Length: 477 AA [This is the length of the unprocessed precursor] |
Molecular weight: 53845 Da [This is the MW of the unprocessed precursor] |
CRC64: 9C15594F45262D37 [This is a checksum on the sequence] |
|
10 20 30 40 50 60
MKGLPVLLWL CVVVCSSYPL HDSARDDDAG MELLQKYLEN YYGLAKDVKQ FIKKKDSSLI
70 80 90 100 110 120
VKKIQEMQKF LGLEMTGKLD SNTMELMHKP RCGVPDVGGF STFPGSPKWR KSHITYRIVN
130 140 150 160 170 180
YTPDLPRQSV DSAIEKALKV WEEVTPLTFS RISEGEADIM ISFAVGEHGD FVPFDGPGTV
190 200 210 220 230 240
LAHAYAPGPG INGDAHFDDD ERWTEDVTGT NLFLVAAHEL GHSLGLYHSA KAEALMYPVY
250 260 270 280 290 300
KSSTDLSRFH LSQDDVDGIQ SLYGTPTASP DVLVVPTKSN SLEPETSPMC SSTLFFDAVS
310 320 330 340 350 360
TLRGEVLFFK DRHFWRKSLR TPEPEFYLIS SFWPSLPSNM DAAYEVTNRD TVFIFKGNQF
370 380 390 400 410 420
WAIRGHEELA GYPKSIHTLG LPATVKKIDA AISNKEKRKT YFFVEDKYWR FDEKKQSMEP
430 440 450 460 470
GFPRKIAEDF PGVDSRVDAV FEAFGFLYFF SGSSQLEFDP NAKKVTHILK SNSWFNC
|
P28862 in FASTA format |
|
ExPASy Home page
SIB Switzerland
