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UniProtKB/Swiss-Prot entry P28566


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name 5HT1E_HUMAN
Primary accession number P28566
Secondary accession number Q9P1Y1
Integrated into Swiss-Prot on December 1, 1992
Sequence was last modified on December 1, 1992 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 84)
Name and origin of the protein
Protein name 5-hydroxytryptamine receptor 1E
Synonyms 5-HT-1E
5-HT1E
Serotonin receptor 1E
S31
Gene name
Name: HTR1E
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=1608964 [NCBI, ExPASy, EBI, Israel, Japan]
McAllister G., Charlesworth A., Snodin C., Beer M.S., Noble A.J., Middlemiss D.N., Iversen L.L., Whiting P.;
"Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype.";
Proc. Natl. Acad. Sci. U.S.A. 89:5517-5521(1992).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0014-5793(92)80379-U; PubMed=1733778 [NCBI, ExPASy, EBI, Israel, Japan]
Levy F.O., Gudermann T., Birnbaumer M., Kaumann A.J., Birnbaumer L.;
"Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase.";
FEBS Lett. 296:201-206(1992).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1513320 [NCBI, ExPASy, EBI, Israel, Japan]
Zgombick J.M., Schechter L.E., Macchi M., Hartig P.R., Branchek T.A., Weinshank R.L.;
"Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor.";
Mol. Pharmacol. 42:180-185(1992).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).";
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02055; PubMed=14574404 [NCBI, ExPASy, EBI, Israel, Japan]
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-363.
Kitano T., Kobayakawa H., Saitou N.;
"Silver project.";
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
[8]
VARIANT PHE-262.
DOI=10.1038/10290; PubMed=10391209 [NCBI, ExPASy, EBI, Israel, Japan]
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.;
"Characterization of single-nucleotide polymorphisms in coding regions of human genes.";
Nat. Genet. 22:231-238(1999).
[9]
ERRATUM.
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.;
Nat. Genet. 23:373-373(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M91467; AAA58353.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z11166; CAA77558.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M92826; AAA58355.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF498980; AAM21127.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL157777; CAC10582.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC069751; AAH69751.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB041373; BAA94458.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S20579; A45260.
RefSeq NP_000856.1; -.
UniGene Hs.1611
3D structure databases
HSSP P08913; 1HLL. [HSSP ENTRY / PDB]
ModBase P28566.
Protein-protein interaction databases
IntAct P28566; -.
Protein family/group databases
GPCRDB P28566; 5HT1E_HUMAN.
Organism-specific databases
H-InvDB HIX0032800; -.
HGNC HGNC:5291; HTR1E.
GenAtlas HTR1E.
HPA HPA004931; -.
MIM 182132; gene. [NCBI / EBI]
PharmGKB PA29552; -.
GeneCards P28566.
Gene expression databases
ArrayExpress P28566; -.
CleanEx HS_HTR1E; -.
GermOnline ENSG00000168830; Homo sapiens.
Ontologies
GO
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0004993; Molecular function: serotonin receptor activity (traceable author statement from ProtInc).
GO:0007187; Biological process: G-protein signaling, coupled to cyclic nucleotide second messenger (traceable author statement from ProtInc).
GO:0007268; Biological process: synaptic transmission (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR000450; 5HT1F_rcpt.
IPR002231; 5HT_rcpt.
IPR000276; GPCR_Rhodpsn.
IPR017452; GPCR_Rhodpsn_supfam.
Graphical view of domain structure.
PANTHER PTHR19266:SF65; 5HT1F_rcpt; 1.
Pfam PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00515; 5HT1FRECEPTR.
PR01101; 5HTRECEPTOR.
PR00237; GPCRRHODOPSN.
PROSITE PS00237; G_PROTEIN_RECEP_F1_1; 1.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P28566.
Genome annotation databases
Ensembl ENSG00000168830; Homo sapiens. [Contig view]
GeneID 3354; -.
KEGG hsa:3354; -.
Phylogenomic databases
HOGENOM P28566; -.
HOVERGEN P28566; -.
Other
DrugBank DB00216; Eletriptan.
SOURCE HTR1E; Homo sapiens.
GPCRDB-Snakes P28566.
ProtoNet P28566.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; Receptor; Transducer; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   365  365     5-hydroxytryptamine receptor 1E. PRO_0000068933
TOPO_DOM   1    22  22     Extracellular (Potential). 
TRANSMEM   23    47  25     1 (Potential). 
TOPO_DOM   48    59  12     Cytoplasmic (Potential). 
TRANSMEM   60    81  22     2 (Potential). 
TOPO_DOM   82    96  15     Extracellular (Potential). 
TRANSMEM   97   118  22     3 (Potential). 
TOPO_DOM   119   138  20     Cytoplasmic (Potential). 
TRANSMEM   139   159  21     4 (Potential). 
TOPO_DOM   160   179  20     Extracellular (Potential). 
TRANSMEM   180   201  22     5 (Potential). 
TOPO_DOM   202   291  90     Cytoplasmic (Potential). 
TRANSMEM   292   314  23     6 (Potential). 
TOPO_DOM   315   324  10     Extracellular (Potential). 
TRANSMEM   325   347  23     7 (Potential). 
TOPO_DOM   348   365  18     Cytoplasmic (Potential). 
CARBOHYD   2     2        N-linked (GlcNAc...) (Potential). 
CARBOHYD   5     5        N-linked (GlcNAc...) (Potential). 
DISULFID   95   173        By similarity. 
VARIANT   208   208  1     A -> T (in dbSNP:rs3828741 [NCBI]). VAR_022061 
VARIANT   262   262  1     S -> F (in dbSNP:rs6303 [NCBI]). VAR_014165 
Sequence information
Length: 365 AA [This is the length of the unprocessed precursor] Molecular weight: 41682 Da [This is the MW of the unprocessed precursor] CRC64: 4C31DD783A3F7483 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNITNCTTEA SMAIRPKTIT EKMLICMTLV VITTLTTLLN LAVIMAIGTT KKLHQPANYL 

        70         80         90        100        110        120 
ICSLAVTDLL VAVLVMPLSI IYIVMDRWKL GYFLCEVWLS VDMTCCTCSI LHLCVIALDR 

       130        140        150        160        170        180 
YWAITNAIEY ARKRTAKRAA LMILTVWTIS IFISMPPLFW RSHRRLSPPP SQCTIQHDHV 

       190        200        210        220        230        240 
IYTIYSTLGA FYIPLTLILI LYYRIYHAAK SLYQKRGSSR HLSNRSTDSQ NSFASCKLTQ 

       250        260        270        280        290        300 
TFCVSDFSTS DPTTEFEKFH ASIRIPPFDN DLDHPGERQQ ISSTRERKAA RILGLILGAF 

       310        320        330        340        350        360 
ILSWLPFFIK ELIVGLSIYT VSSEVADFLT WLGYVNSLIN PLLYTSFNED FKLAFKKLIR 


CREHT 

P28566 in FASTA format

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