[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1016/0888-7543(91)90034-C; PubMed=1664410 [NCBI, ExPASy, EBI, Israel, Japan] Wagstaff J., Chaillet J.R., Lalande M.; "The GABAA receptor beta 3 subunit gene: characterization of a human cDNA from chromosome 15q11q13 and mapping to a region of conserved synteny on mouse chromosome 7."; Genomics 11:1071-1078(1991).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Eye; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-80 (ISOFORMS 1 AND 2). TISSUE=Fibroblast; PubMed=8382702 [NCBI, ExPASy, EBI, Israel, Japan] Kirkness E.F., Fraser C.M.; "A strong promoter element is located between alternative exons of a gene encoding the human gamma-aminobutyric acid-type A receptor beta 3 subunit (GABRB3)."; J. Biol. Chem. 268:4420-4428(1993).
[4]	NUCLEOTIDE SEQUENCE OF 81-153 AND 183-227. PubMed=1714232 [NCBI, ExPASy, EBI, Israel, Japan] Wagstaff J., Knoll J.H.M., Fleming J., Kirkness E.F., Martin-Gallardo A., Greenberg F., Graham J.M. Jr., Menninger J., Ward D., Venter J.C., Lalande M.; "Localization of the gene encoding the GABAA receptor beta 3 subunit to the Angelman/Prader-Willi region of human chromosome 15."; Am. J. Hum. Genet. 49:330-337(1991).

Comments

FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
SUBUNIT: Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing. Isoforms differ in their signal region.

Name 1

Isoform ID P28472-1

This is the isoform sequence displayed in this entry.

Name 2

Isoform ID P28472-2

Features which should be applied to build the isoform sequence: VSP_000088.
SIMILARITY: Belongs to the ligand-gated ionic channel (TC 1.A.9) family [view classification].
WEB RESOURCE: Name=Protein Spotlight; Note=Forbidden fruit - Issue 56 of March 2005; URL="http://www.expasy.org/spotlight/back_issues/sptlt056.shtml";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M82919; AAA52511.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC010641; AAH10641.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
L04311; AAA52508.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
L04311; AAA52507.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A55275; A55275.
B45468; B45468.

RefSeq

NP_000805.1; -.
NP_068712.1; -.

UniGene

Hs.302352

3D structure databases

ModBase

P28472.

PTM databases

PhosphoSite

P28472; -.

Organism-specific databases

HIX0012052; -.

HGNC:4083; GABRB3.

137192; gene. [NCBI / EBI]

PharmGKB

PA28497; -.

GeneCards

P28472.

Gene expression databases

ArrayExpress

P28472; -.

CleanEx

HS_GABRB3; -.

GermOnline

ENSG00000166206; Homo sapiens.

Ontologies

GO:0005887;	Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0004890;	Molecular function: GABA-A receptor activity (traceable author statement from ProtInc).
GO:0007165;	Biological process: signal transduction (traceable author statement from ProtInc).
GO:0006810;	Biological process: transport (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR006028; GABAA_rcpt.
IPR002289; GABAAb_rcpt.
IPR006029; Neu_channel_TM.
IPR006202; Neur_chan_lig_bd.
IPR006201; Neur_channel.
Graphical view of domain structure.

Gene3D

G3DSA:2.70.170.10; Neur_chan_lig_bd; 1.

PANTHER

PTHR18945; Neur_channel; 1.

Pfam

PF02931; Neur_chan_LBD; 1.
PF02932; Neur_chan_memb; 1.
Pfam graphical view of domain structure.

PRINTS

PR01160; GABAARBETA.
PR00253; GABAARECEPTR.
PR00252; NRIONCHANNEL.

TIGRFAMs

TIGR00860; LIC; 1.

PROSITE

PS00236; NEUROTR_ION_CHANNEL; 1.

BLOCKS

P28472.

Genome annotation databases

Ensembl

ENSG00000166206; Homo sapiens. [Contig view]

GeneID

2562; -.

KEGG

hsa:2562; -.

Phylogenomic databases

HOVERGEN

P28472; -.

Other

DrugBank

DB00189; Ethchlorvynol.
DB00690; Flurazepam.
DB00186; Lorazepam.
DB00683; Midazolam.

SOURCE

GABRB3; Homo sapiens.

ProtoNet

P28472.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Cell junction; Cell membrane; Chloride; Chloride channel; Glycoprotein; Ion transport; Ionic channel; Membrane; Postsynaptic cell membrane; Signal; Synapse; Transmembrane; Transport.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 25`	`25`	`Potential.`
`CHAIN`	`26 473`	`448`	`Gamma-aminobutyric acid receptor subunit beta-3.`	`PRO_0000000462`
`TOPO_DOM`	`26 245`	`220`	`Extracellular (Probable).`
`TRANSMEM`	`246 267`	`22`	`Probable.`
`TRANSMEM`	`271 293`	`23`	`Probable.`
`TRANSMEM`	`305 327`	`23`	`Probable.`
`TOPO_DOM`	`328 450`	`123`	`Cytoplasmic (Probable).`
`TRANSMEM`	`451 472`	`22`	`Probable.`
`CARBOHYD`	`33 33`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`105 105`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`174 174`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`161 175`		`By similarity.`
`VAR_SEQ`	`1 26`		`MWGLAGGRLFGIFSAPVLVAVVCCAQ -> MCSGLLELLLPIWLSWTLGTRGSEPR (in isoform 2).`	`VSP_000088`
`CONFLICT`	`173 173`		`Q -> L (in Ref. 2; AAH10641).`

Sequence information

Length: 473 AA [This is the length of the unprocessed precursor]

Molecular weight: 54116 Da [This is the MW of the unprocessed precursor]

CRC64: D63597F7FBC69E71 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MWGLAGGRLF GIFSAPVLVA VVCCAQSVND PGNMSFVKET VDKLLKGYDI RLRPDFGGPP 

        70         80         90        100        110        120 
VCVGMNIDIA SIDMVSEVNM DYTLTMYFQQ YWRDKRLAYS GIPLNLTLDN RVADQLWVPD 

       130        140        150        160        170        180 
TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL YGLRITTTAA CMMDLRRYPL DEQNCTLEIE 

       190        200        210        220        230        240 
SYGYTTDDIE FYWRGGDKAV TGVERIELPQ FSIVEHRLVS RNVVFATGAY PRLSLSFRLK 

       250        260        270        280        290        300 
RNIGYFILQT YMPSILITIL SWVSFWINYD ASAARVALGI TTVLTMTTIN THLRETLPKI 

       310        320        330        340        350        360 
PYVKAIDMYL MGCFVFVFLA LLEYAFVNYI FFGRGPQRQK KLAEKTAKAK NDRSKSESNR 

       370        380        390        400        410        420 
VDAHGNILLT SLEVHNEMNE VSGGIGDTRN SAISFDNSGI QYRKQSMPRE GHGRFLGDRS 

       430        440        450        460        470 
LPHKKTHLRR RSSQLKIKIP DLTDVNAIDR WSRIVFPFTF SLFNLVYWLY YVN

P28472 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools