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[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=(68)-VIII;
DOI=10.1093/nar/20.22.5985; PubMed=1461731 [NCBI, ExPASy, EBI, Israel, Japan]
Kaufmann J.,
Florian V.,
Klein A.;
"TGA cysteine codons and intron sequences in conserved and nonconserved positions are found in macronuclear RNA polymerase genes of Euplotes octocarinatus.";
Nucleic Acids Res. 20:5985-5989(1992).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-546.
STRAIN=(68)-VIII;
DOI=10.1093/nar/20.17.4445; PubMed=1408746 [NCBI, ExPASy, EBI, Israel, Japan]
Kaufmann J.,
Klein A.;
"Gene dosage as a possible major determinant for equal expression levels of genes encoding RNA polymerase subunits in the hypotrichous ciliate Euplotes octocarinatus.";
Nucleic Acids Res. 20:4445-4450(1992).
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- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
- SUBUNIT: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits (By similarity).
- SUBCELLULAR LOCATION: Nucleus, nucleolus (By similarity).
- SIMILARITY: Belongs to the RNA polymerase beta chain family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 1166 AA [This is the length of the unprocessed precursor] |
Molecular weight: 132714 Da [This is the MW of the unprocessed precursor] |
CRC64: 7253965D6173F0C9 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MKTNAKFDRK EISKIYKNIA RHHIDSFDFA MSTCLNRACE HMLPFDYIVP EESASCGFKK
70 80 90 100 110 120
LTLWYDSFEL GQPSLGEIDY DSHILYPSEC RQRKMTYTIP LFATIFKKFD DEMVDNFKVK
130 140 150 160 170 180
LGDIPTMGRK KFCNLKGLTK KELAKRGEDM LEFGGYFIVN GNEKVIRMLI VPKRNFPIAF
190 200 210 220 230 240
KRSKFLERGK DFTDYGVQMR CVRDDFTAQT ITLTYLSDGS VSLRLIYQKQ EFLIPIILIL
250 260 270 280 290 300
KALKNCTDRQ IYERIVKGNF NQRQISDRVE AILAVGKDLN IYDSDQSKAL IGSRFRIVLA
310 320 330 340 350 360
GITSETSDID AGDLFLSKHI CIHTDSYEAK FDTLILMIDK LYASVANEVE LDNLDSVAMQ
370 380 390 400 410 420
DVLLGGHLYL QILSEKLFDC LHINLRARLN KELKRHNFDP MKFRDVLTNQ KINCGIGLIG
430 440 450 460 470 480
KRMENFLATG NLISRTNLDL MQTSGFCIIG DKLNNIRFLS HFRSIHRGQY FAEQKTTSVR
490 500 510 520 530 540
KLLPESWGFI CPVHTPDGAP CGLLNHISMS CVPIGSEEKQ IDIDKFRNIL GELGMNSISS
550 560 570 580 590 600
DLCLNYHTGY YPVIFDGIHL GYVEKDIGES FVEGLRYLKC TQSQPDYAIP RTLEIAFIPF
610 620 630 640 650 660
SGYSRNLQWP GIFLASTPAR FTRPVKNLHY NCIEWISPLE QMNLSIACTD EDITPETTHQ
670 680 690 700 710 720
ELDPINILSI VASVGVFAEY NQSPRNMYQC QMAKQTMGTP YHNHQFRTDN KIYRLLFPHR
730 740 750 760 770 780
PIVKTRTQVD FDIEEYPSGT NAVVAVISYT GYDLEDAMII NKSSYERGFG HGVVYKSYTH
790 800 810 820 830 840
DLNESNSQST RGIKSSVRYK FLNNVSQKDK SKIKLENIDP DGLPKIGSQL TKGKPELCIF
850 860 870 880 890 900
DTLKRGAKLS KFKDSEKARI ETVRVCGNDD KNPDNLSIGY TIRYSRIPVI GDKFSSRHGQ
910 920 930 940 950 960
KGVLSVLWPQ VDMPFTENGI TPDLIINPHA FPSRMTMGML IQSMAAKSGS LRGEFKTVET
970 980 990 1000 1010 1020
FQRYDDNDIV GHFGKELLDK GFNYHGNELM YSGIFGTPLK ADIFIGVVYY QRLRHMVSDK
1030 1040 1050 1060 1070 1080
SQARGTGPID ILTHQPVKGR KKGGGIRFGE MERDSLLAHG AAYCLNDRLF RSSDYSEGFV
1090 1100 1110 1120 1130 1140
CQNCGSILSC YVNRAIMKTQ TFIPPSLDES NKDTEDKEIH MNEKVICKVC KKNSNCKKVA
1150 1160
LPFVLRFLAN ELASMGIKLK FTVNDF
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P28365 in FASTA format |
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ExPASy Home page
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