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UniProtKB/Swiss-Prot entry P28222


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name 5HT1B_HUMAN
Primary accession number P28222
Secondary accession number Q4VAY7
Integrated into Swiss-Prot on December 1, 1992
Sequence was last modified on December 1, 1992 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 84)
Name and origin of the protein
Protein name 5-hydroxytryptamine receptor 1B
Synonyms 5-HT-1D-beta
5-HT-1B
5-HT1B
Serotonin receptor 1B
Serotonin 1D beta receptor
S12
Gene name
Name: HTR1B
Synonyms: HTR1DB
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0006-291X(92)90654-4; PubMed=1315531 [NCBI, ExPASy, EBI, Israel, Japan]
Hamblin M.W., Metcalf M.A., McGuffin R.W., Karpells S.;
"Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity.";
Biochem. Biophys. Res. Commun. 184:752-759(1992).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0006-291X(92)91655-A; PubMed=1610347 [NCBI, ExPASy, EBI, Israel, Japan]
Mochizuki D., Yuyama Y., Tsujita R., Komaki H., Sagai H.;
"Cloning and expression of the human 5-HT1B-type receptor gene.";
Biochem. Biophys. Res. Commun. 185:517-523(1992).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1348246 [NCBI, ExPASy, EBI, Israel, Japan]
Jin H., Oksenberg D., Ashkenazi A., Peroutka S.J., Duncan A.M.V., Rozmahel R., Yang Y., Mengod G., Palacios J.M., O'Dowd B.F.;
"Characterization of the human 5-hydroxytryptamine1B receptor.";
J. Biol. Chem. 267:5735-5738(1992).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1559993 [NCBI, ExPASy, EBI, Israel, Japan]
Levy F.O., Gudermann T., Perez-Reyes E., Birnbaumer M., Kaumann A.J., Birnbaumer L.;
"Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype.";
J. Biol. Chem. 267:7553-7562(1992).
[5]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
PubMed=1565658 [NCBI, ExPASy, EBI, Israel, Japan]
Weinshank R.L., Zgombick J.M., Macchi M.J., Branchek T.A., Hartig P.R.;
"Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.";
Proc. Natl. Acad. Sci. U.S.A. 89:3630-3634(1992).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1351684 [NCBI, ExPASy, EBI, Israel, Japan]
Demchyshyn L., Sunahara R.K., Miller K., Teitler M., Hoffman B.J., Kennedy J.L., Seeman P., van Tol H.H.M., Niznik H.B.;
"A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6.";
Proc. Natl. Acad. Sci. U.S.A. 89:5522-5526(1992).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1328844 [NCBI, ExPASy, EBI, Israel, Japan]
Veldman S.A., Bienkowski M.J.;
"Cloning and pharmacological characterization of a novel human 5-hydroxytryptamine1D receptor subtype.";
Mol. Pharmacol. 42:439-444(1992).
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Kitano T., Kobayakawa H., Saitou N.;
"Silver project.";
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Kopatz S.A., Aronstam R.S., Sharma S.V.;
"Isolation of complete coding sequence for 5-hydroxytryptamine (serotonin) receptor 1B (HTR1B).";
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
[10]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02055; PubMed=14574404 [NCBI, ExPASy, EBI, Israel, Japan]
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[11]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[12]
PALMITOYLATION, AND PHOSPHORYLATION.
DOI=10.1021/bi00094a032; PubMed=8218242 [NCBI, ExPASy, EBI, Israel, Japan]
Ng G.Y.K., George S.R., Zastawny R.L., Caron M., Bouvier M., Dennis M., O'Dowd B.F.;
"Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition.";
Biochemistry 32:11727-11733(1993).
[13]
VARIANT CYS-124.
DOI=10.1006/bbrc.1994.2792; PubMed=7802650 [NCBI, ExPASy, EBI, Israel, Japan]
Nothen M.M., Erdmann J., Shimron-Abarbanell D., Propping P.;
"Identification of genetic variation in the human serotonin 1D beta receptor gene.";
Biochem. Biophys. Res. Commun. 205:1194-1200(1994).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M89478; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
D10995; BAA01763.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M83180; AAA36029.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L09732; AAA36030.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M81590; AAA60316.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M75128; AAA58675.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB041370; BAA94455.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY225227; AAO67712.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL049595; CAB51537.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC069065; AAH69065.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC096206; AAH96206.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC096207; AAH96207.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC096208; AAH96208.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JN0268; JN0268.
RefSeq NP_000854.1; -.
UniGene Hs.123016
3D structure databases
PDB
2G1X; Model; -; A=1-390.[ExPASy / RCSB / EBI]
PDBsum 2G1X; -.
ModBase P28222.
Protein-protein interaction databases
IntAct P28222; -.
Protein family/group databases
GPCRDB P28222; 5HT1B_HUMAN.
Organism-specific databases
H-InvDB HIX0032923; -.
HGNC HGNC:5287; HTR1B.
GenAtlas HTR1B.
MIM 182131; gene. [NCBI / EBI]
PharmGKB PA29549; -.
GeneCards P28222.
Gene expression databases
ArrayExpress P28222; -.
CleanEx HS_HTR1B; -.
GermOnline ENSG00000135312; Homo sapiens.
Ontologies
GO
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0004993; Molecular function: serotonin receptor activity (traceable author statement from ProtInc).
GO:0007187; Biological process: G-protein signaling, coupled to cyclic nucleotide second messenger (traceable author statement from ProtInc).
GO:0007268; Biological process: synaptic transmission (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR002147; 5HT1B_rcpt.
IPR002231; 5HT_rcpt.
IPR000276; GPCR_Rhodpsn.
IPR017452; GPCR_Rhodpsn_supfam.
Graphical view of domain structure.
PANTHER PTHR19266:SF67; 5HT1B_rcpt; 1.
Pfam PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00513; 5HT1BRECEPTR.
PR01101; 5HTRECEPTOR.
PR00237; GPCRRHODOPSN.
PROSITE PS00237; G_PROTEIN_RECEP_F1_1; 1.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P28222.
ProtoNet P28222.
Genome annotation databases
Ensembl ENSG00000135312; Homo sapiens. [Contig view]
GeneID 3351; -.
KEGG hsa:3351; -.
Phylogenomic databases
HOGENOM P28222; -.
HOVERGEN P28222; -.
Other
DrugBank DB00918; Almotriptan.
DB01191; Dexfenfluramine.
DB00320; Dihydroergotamine.
DB00216; Eletriptan.
DB00696; Ergotamine.
DB00998; Frovatriptan.
DB00952; Naratriptan.
DB00960; Pindolol.
DB00571; Propranolol.
DB00953; Rizatriptan.
DB00669; Sumatriptan.
DB00285; Venlafaxine.
DB00315; Zolmitriptan.
NextBio 13252; -.
SOURCE HTR1B; Homo sapiens.
GPCRDB-Snakes P28222.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Cell membrane; G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Polymorphism; Receptor; Transducer; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   390  390     5-hydroxytryptamine receptor 1B. PRO_0000068916
TOPO_DOM   1    49  49     Extracellular (Potential). 
TRANSMEM   50    73  24     1 (Potential). 
TOPO_DOM   74    86  13     Cytoplasmic (Potential). 
TRANSMEM   87   109  23     2 (Potential). 
TOPO_DOM   110   119  10     Extracellular (Potential). 
TRANSMEM   120   145  26     3 (Potential). 
TOPO_DOM   146   165  20     Cytoplasmic (Potential). 
TRANSMEM   166   187  22     4 (Potential). 
TOPO_DOM   188   205  18     Extracellular (Potential). 
TRANSMEM   206   229  24     5 (Potential). 
TOPO_DOM   230   315  86     Cytoplasmic (Potential). 
TRANSMEM   316   340  25     6 (Potential). 
TOPO_DOM   341   347  7     Extracellular (Potential). 
TRANSMEM   348   373  26     7 (Potential). 
TOPO_DOM   374   390  17     Cytoplasmic (Potential). 
LIPID   388   388        S-palmitoyl cysteine (Potential). 
CARBOHYD   24    24        N-linked (GlcNAc...) (Potential). 
CARBOHYD   32    32        N-linked (GlcNAc...) (Potential). 
DISULFID   122   199        By similarity. 
VARIANT   124   124  1     F -> C (in dbSNP:rs130060 [NCBI]). VAR_011715 
VARIANT   219   219  1     F -> L (in dbSNP:rs130061 [NCBI]). VAR_011831 
VARIANT   367   367  1     I -> V (in dbSNP:rs130063 [NCBI]). VAR_011832 
VARIANT   374   374  1     E -> K (in dbSNP:rs130064 [NCBI]). VAR_011833 
Sequence information
Length: 390 AA [This is the length of the unprocessed precursor] Molecular weight: 43568 Da [This is the MW of the unprocessed precursor] CRC64: CD874DC7EB44CF12 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEEPGAQCAP PPPAGSETWV PQANLSSAPS QNCSAKDYIY QDSISLPWKV LLVMLLALIT 

        70         80         90        100        110        120 
LATTLSNAFV IATVYRTRKL HTPANYLIAS LAVTDLLVSI LVMPISTMYT VTGRWTLGQV 

       130        140        150        160        170        180 
VCDFWLSSDI TCCTASILHL CVIALDRYWA ITDAVEYSAK RTPKRAAVMI ALVWVFSISI 

       190        200        210        220        230        240 
SLPPFFWRQA KAEEEVSECV VNTDHILYTV YSTVGAFYFP TLLLIALYGR IYVEARSRIL 

       250        260        270        280        290        300 
KQTPNRTGKR LTRAQLITDS PGSTSSVTSI NSRVPDVPSE SGSPVYVNQV KVRVSDALLE 

       310        320        330        340        350        360 
KKKLMAARER KATKTLGIIL GAFIVCWLPF FIISLVMPIC KDACWFHLAI FDFFTWLGYL 

       370        380        390 
NSLINPIIYT MSNEDFKQAF HKLIRFKCTS 

P28222 in FASTA format

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