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UniProtKB/Swiss-Prot entry P28221


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name 5HT1D_HUMAN
Primary accession number P28221
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 1992
Sequence was last modified on December 1, 1992 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 88)
Name and origin of the protein
Protein name 5-hydroxytryptamine receptor 1D
Synonyms 5-HT-1D
5-HT-1D-alpha
Serotonin receptor 1D
Gene name
Name: HTR1D
Synonyms: HTR1DA, HTRL
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1652050 [NCBI, ExPASy, EBI, Israel, Japan]
Hamblin M.W., Metcalf M.A.;
"Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.";
Mol. Pharmacol. 40:143-148(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
DOI=10.1073/pnas.89.8.3630; PubMed=1565658 [NCBI, ExPASy, EBI, Israel, Japan]
Weinshank R.L., Zgombick J.M., Macchi M.J., Branchek T.A., Hartig P.R.;
"Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.";
Proc. Natl. Acad. Sci. U.S.A. 89:3630-3634(1992).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).";
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Eye;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
VARIANT LEU-265.
DOI=10.1038/10290; PubMed=10391209 [NCBI, ExPASy, EBI, Israel, Japan]
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.;
"Characterization of single-nucleotide polymorphisms in coding regions of human genes.";
Nat. Genet. 22:231-238(1999).
[8]
ERRATUM.
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.;
Nat. Genet. 23:373-373(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M89955; AAA35491.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M81589; AAA60315.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF498979; AAM21126.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT007027; AAP35673.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL049576; CAB81617.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC007720; AAH07720.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00002183; -.
PIR A53279; A53279.
RefSeq NP_000855.1; -.
UniGene Hs.121482
3D structure databases
HSSP P08913; 1HLL. [HSSP ENTRY / PDB]
ModBase P28221.
Protein family/group databases
GPCRDB P28221; 5HT1D_HUMAN.
Organism-specific databases
GeneCards GC01M023389; -.
H-InvDB HIX0000241; -.
HGNC HGNC:5289; HTR1D.
GenAtlas HTR1D.
MIM 182133; gene. [NCBI / EBI]
PharmGKB PA29550; -.
Gene expression databases
ArrayExpress P28221; -.
Bgee P28221; -.
CleanEx HS_HTR1D; -.
GermOnline ENSG00000179546; Homo sapiens.
Ontologies
GO
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0004993; Molecular function: serotonin receptor activity (traceable author statement from ProtInc).
GO:0007187; Biological process: G-protein signaling, coupled to cyclic nucleotide second messenger (traceable author statement from ProtInc).
GO:0007268; Biological process: synaptic transmission (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR000505; 5HT1D_rcpt.
IPR002231; 5HT_rcpt.
IPR000276; 7TM_GPCR_Rhodpsn.
IPR017452; GPCR_Rhodpsn_supfam.
Graphical view of domain structure.
PANTHER PTHR19266:SF66; 5HT1D_rcpt; 1.
Pfam PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00514; 5HT1DRECEPTR.
PR01101; 5HTRECEPTOR.
PR00237; GPCRRHODOPSN.
PROSITE PS00237; G_PROTEIN_RECEP_F1_1; 1.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE P28221; -.
Genome annotation databases
Ensembl ENSG00000179546; Homo sapiens. [Contig view]
GeneID 3352; -.
KEGG hsa:3352; -.
Phylogenomic databases
HOGENOM P28221; -.
HOVERGEN P28221; -.
OMA P28221; RDSCWIH.
Other
DrugBank DB00918; Almotriptan.
DB00320; Dihydroergotamine.
DB00216; Eletriptan.
DB00696; Ergotamine.
DB00998; Frovatriptan.
DB00952; Naratriptan.
DB00953; Rizatriptan.
DB00669; Sumatriptan.
DB01079; Tegaserod.
DB00246; Ziprasidone.
DB00315; Zolmitriptan.
NextBio 13256; -.
SOURCE HTR1D; Homo sapiens.
GPCRDB-Snakes P28221.
ProtoNet P28221.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; Receptor; Transducer; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   377  377     5-hydroxytryptamine receptor 1D. PRO_0000068927
TOPO_DOM   1    38  38     Extracellular (By similarity). 
TRANSMEM   39    62  24     1 (By similarity). 
TOPO_DOM   63    75  13     Cytoplasmic (By similarity). 
TRANSMEM   76    98  23     2 (By similarity). 
TOPO_DOM   99   108  10     Extracellular (By similarity). 
TRANSMEM   109   134  26     3 (By similarity). 
TOPO_DOM   135   154  20     Cytoplasmic (By similarity). 
TRANSMEM   155   176  22     4 (By similarity). 
TOPO_DOM   177   194  18     Extracellular (By similarity). 
TRANSMEM   195   218  24     5 (By similarity). 
TOPO_DOM   219   302  84     Cytoplasmic (By similarity). 
TRANSMEM   303   326  24     6 (By similarity). 
TOPO_DOM   327   335  9     Extracellular (By similarity). 
TRANSMEM   336   360  25     7 (By similarity). 
TOPO_DOM   361   377  17     Cytoplasmic (By similarity). 
CARBOHYD   5     5        N-linked (GlcNAc...) (Potential). 
CARBOHYD   17    17        N-linked (GlcNAc...) (Potential). 
CARBOHYD   21    21        N-linked (GlcNAc...) (Potential). 
DISULFID   111   188        By similarity. 
VARIANT   265   265  1     S -> L (in dbSNP:rs6299 [NCBI]). VAR_011834 
Sequence information
Length: 377 AA [This is the length of the unprocessed precursor] Molecular weight: 41907 Da [This is the MW of the unprocessed precursor] CRC64: 0A4FCF81FFE2322A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSPLNQSAEG LPQEASNRSL NATETSEAWD PRTLQALKIS LAVVLSVITL ATVLSNAFVL 

        70         80         90        100        110        120 
TTILLTRKLH TPANYLIGSL ATTDLLVSIL VMPISIAYTI THTWNFGQIL CDIWLSSDIT 

       130        140        150        160        170        180 
CCTASILHLC VIALDRYWAI TDALEYSKRR TAGHAATMIA IVWAISICIS IPPLFWRQAK 

       190        200        210        220        230        240 
AQEEMSDCLV NTSQISYTIY STCGAFYIPS VLLIILYGRI YRAARNRILN PPSLYGKRFT 

       250        260        270        280        290        300 
TAHLITGSAG SSLCSLNSSL HEGHSHSAGS PLFFNHVKIK LADSALERKR ISAARERKAT 

       310        320        330        340        350        360 
KILGIILGAF IICWLPFFVV SLVLPICRDS CWIHPALFDF FTWLGYLNSL INPIIYTVFN 

       370 
EEFRQAFQKI VPFRKAS 

P28221 in FASTA format

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