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UniProtKB/Swiss-Prot entry P28166


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ZFH1_DROME
Primary accession number P28166
Secondary accession numbers Q59DT3 Q6NP51 Q8MSQ8 Q9VA39 Q9VA40
Integrated into Swiss-Prot on October 1, 1994
Sequence was last modified on March 15, 2004 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 84)
Name and origin of the protein
Protein name Zinc finger protein 1
Synonym Zinc finger homeodomain protein 1
Gene name
Name: zfh1
Synonyms: zfh-1
ORFNames: CG1322
From
Drosophila melanogaster (Fruit fly) [TaxID: 7227] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND TISSUE SPECIFICITY.
DOI=10.1016/0925-4773(91)90048-B; PubMed=1680376 [NCBI, ExPASy, EBI, Israel, Japan]
Fortini M.E., Lai Z., Rubin G.M.;
"The Drosophila zfh-1 and zfh-2 genes encode novel proteins containing both zinc-finger and homeodomain motifs.";
Mech. Dev. 34:113-122(1991).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
DOI=10.1126/science.287.5461.2185; PubMed=10731132 [NCBI, ExPASy, EBI, Israel, Japan]
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[3]
GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
PubMed=12537572 [NCBI, ExPASy, EBI, Israel, Japan]
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
STRAIN=Berkeley;
TISSUE=Embryo;
PubMed=12537569 [NCBI, ExPASy, EBI, Israel, Japan]
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.;
"A Drosophila full-length cDNA resource.";
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 30-1054 (ISOFORM 1).
STRAIN=Berkeley;
TISSUE=Embryo;
Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-582; SER-586 AND SER-934, AND MASS SPECTROMETRY.
TISSUE=Embryo;
DOI=10.1021/pr700696a; PubMed=18327897 [NCBI, ExPASy, EBI, Israel, Japan]
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
J. Proteome Res. 7:1675-1682(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M63449; AAA29050.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014297; AAF57083.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014297; AAF57084.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014297; AAN14258.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY118654; AAM50023.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT003277; AAO25034.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT011080; AAR82746.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S33641; S33641.
RefSeq NP_476850.1; -.
NP_733401.2; -.
NP_733402.1; -.
UniGene Dm.4708
3D structure databases
HSSP P08153; 1ZFD. [HSSP ENTRY / PDB]
ModBase P28166.
Protein-protein interaction databases
IntAct P28166; -.
Enzyme and pathway databases
BioCyc DMEL-XXX-02:DMEL-XXX-02-014232-MON; -.
Organism-specific databases
FlyBase FBgn0004606; zfh1.
Gene expression databases
ArrayExpress P28166; -.
GermOnline CG1322; Drosophila melanogaster.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from InterPro).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0043565; Molecular function: sequence-specific DNA binding (inferred from electronic annotation from InterPro).
GO:0003700; Molecular function: transcription factor activity (inferred from electronic annotation from InterPro).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0019730; Biological process: antimicrobial humoral response (inferred from mutant phenotype from FlyBase).
GO:0007514; Biological process: garland cell differentiation (inferred from mutant phenotype from FlyBase).
GO:0008406; Biological process: gonad development (traceable author statement from FlyBase).
GO:0007507; Biological process: heart development (non-traceable author statement from FlyBase).
GO:0048542; Biological process: lymph gland development (inferred from mutant phenotype from FlyBase).
GO:0007498; Biological process: mesoderm development (inferred from expression pattern from FlyBase).
GO:0008045; Biological process: motor axon guidance (inferred from mutant phenotype from FlyBase).
GO:0007280; Biological process: pole cell migration (traceable author statement from FlyBase).
GO:0006355; Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001356; Homeobox.
IPR012287; Homeodomain-rel.
IPR007087; Znf_C2H2.
IPR015880; Znf_C2H2-like.
IPR013087; Znf_C2H2/integrase_DNA-bd.
Graphical view of domain structure.
Gene3D G3DSA:1.10.10.60; Homeodomain-rel; 1.
G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 3.
Pfam PF00046; Homeobox; 1.
PF00096; zf-C2H2; 8.
Pfam graphical view of domain structure.
PRINTS PR00024; HOMEOBOX.
ProDom PD000010; Homeobox; 1.
PD000003; Znf_C2H2; 2.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00389; HOX; 1.
SM00355; ZnF_C2H2; 9.
SMART graphical view of domain structure.
PROSITE PS00027; HOMEOBOX_1; 1.
PS50071; HOMEOBOX_2; 1.
PS00028; ZINC_FINGER_C2H2_1; 6.
PS50157; ZINC_FINGER_C2H2_2; 9.
PROSITE graphical view of domain structure (profiles).
BLOCKS P28166.
ProtoNet P28166.
Genome annotation databases
Ensembl CG1322; Drosophila melanogaster. [Contig view]
GeneID 43650; -.
KEGG dme:Dmel_CG1322; -.
NMPDR fig|7227.3.peg.15505; -.
Phylogenomic databases
HOGENOM P28166; -.
Other
NextBio 835065; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Complete proteome; DNA-binding; Homeobox; Metal-binding; Nucleus; Phosphoprotein; Repeat; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1054  1054     Zinc finger protein 1. PRO_0000047241
ZN_FING   74     97  24     C2H2-type 1. 
ZN_FING   289    311  23     C2H2-type 2. 
ZN_FING   324    346  23     C2H2-type 3. 
ZN_FING   355    377  23     C2H2-type 4. 
ZN_FING   383    407  25     C2H2-type 5. 
ZN_FING   628    651  24     C2H2-type 6. 
DNA_BIND   699    758  60     Homeobox. 
ZN_FING   967    989  23     C2H2-type 7. 
ZN_FING   995   1017  23     C2H2-type 8. 
ZN_FING   1023   1044  22     C2H2-type 9. 
COMPBIAS   222    246  25     Gln-rich (OPA repeat). 
MOD_RES   582    582        Phosphoserine. 
MOD_RES   586    586        Phosphoserine. 
MOD_RES   934    934        Phosphoserine. 
VAR_SEQ   1    307        Missing (in isoform 2). VSP_009670
VAR_SEQ   308    324        EQLHSPCGPAAVSNVSQ -> MSAAACLLSSSTSSFEK (in isoform 2). VSP_009671
VAR_SEQ   344    538        Missing (in isoform 3). VSP_009672
CONFLICT   78     78        Q -> K (in Ref. 5; AAR82746). 
CONFLICT   147    147        S -> T (in Ref. 5; AAR82746). 
CONFLICT   239    239        Q -> QMQQQQQ (in Ref. 1). 
CONFLICT   625    625        A -> S (in Ref. 1, 4 and 5; AAR82746). 
CONFLICT   954    954        A -> V (in Ref. 1; AAA29050). 
Sequence information
Length: 1054 AA [This is the length of the unprocessed precursor] Molecular weight: 116598 Da [This is the MW of the unprocessed precursor] CRC64: 5189AB2214AB5B8B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLSCLAPSSS RFGQEDTIIQ QSMPSTSPFA MQFPSLASTL LHHNQSPKHS NPGSSGIQDA 

        70         80         90        100        110        120 
HPNQPGAAAD AFLVKCTQCH KRFPEYQSLS EHIASEHPHD KLNCGAAQPE SDAEDEQSNM 

       130        140        150        160        170        180 
SGSSRRYAKS PLASNNNSST ANANNNSTSS QSMNNNSELA KNHNSANKMS PMCSPGSLTP 

       190        200        210        220        230        240 
GDLFAQLQHP PPQLPPHLHA QFMAAAASLA MQSARTASSP SQQQQQQLQQ QQQLQQQQQH 

       250        260        270        280        290        300 
QMAMQQLLPP QLPGSNSSVG SNSAYDLDLS APRSTSSPGS TTGDLSGAYP CMQCTASFAS 

       310        320        330        340        350        360 
REQLEQHEQL HSPCGPAAVS NVSQTCRICH KAFANVYRLQ RHMISHDESA LLRKFKCKEC 

       370        380        390        400        410        420 
DKAFKFKHHL KEHVRIHSGE KPFGCDNCGK RFSHSGSFSS HMTSKKCISM GLKLNNNRAL 

       430        440        450        460        470        480 
LKRLEKSPGS ASSASRRSPS DHGKGKLPEQ PSLPGLPHPM SYFASDAQVQ GGSAAPAPFP 

       490        500        510        520        530        540 
PFHPNYMNAA LLAFPHNFMA AAAGLDPRVH PYSIQRLLQL SAAGQQQREE EREEQQKQQQ 

       550        560        570        580        590        600 
HDEEETPDEP KLVMDIEEPE TKEMAPTPEA TEAATPIKRE ESREASPDPE SYRSSSQAIK 

       610        620        630        640        650        660 
QEQEPLNVAE ERQTPVEEHA PVEHAADLRC SRCSKQFNHP TELVQHEKVL CGLIKEELEQ 

       670        680        690        700        710        720 
HFQQQQATSF ALASASEEDE EDEEMDVEEE PRQESGERKV RVRTAINEEQ QQQLKQHYSL 

       730        740        750        760        770        780 
NARPSRDEFR MIAARLQLDP RVVQVWFQNN RSRERKMQSF QNNQAAGAAP PMPIDSQASL 

       790        800        810        820        830        840 
TREDQPLDLS VKRDPLTPKS ESSPPYIAPP SGEALNPEAI NLSRKFSTSA SMSPASISPS 

       850        860        870        880        890        900 
SAAALYFGAA PPPSPPNSQL DSTPRSGQAF PGLPPYMLPM SLPMEALFKM RPGGDFASNH 

       910        920        930        940        950        960 
ALMNSIKLPD YRGTSLSPGG SEKRSWRDDD SRISHEDEFG AGVLMPPKPR RGKAETHGHA 

       970        980        990       1000       1010       1020 
GDPDLPYVCD QCDKAFAKQS SLARHKYEHS GQRPYQCIEC PKAFKHKHHL TEHKRLHSGE 

      1030       1040       1050 
KPFQCSKCLK RFSHSGSYSQ HMNHRYSYCK PYRE 

P28166 in FASTA format

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