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- FUNCTION: Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu (By similarity).
- FUNCTION: Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).
- FUNCTION: Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).
- FUNCTION: p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
- SUBUNIT: Matrix protein p17 is a trimer. Interacts with gp120. p6-gag interacts with host TSG101 and PDCD6IP/AIP1 (By similarity).
- SUBCELLULAR LOCATION: Matrix protein p17: Virion (Potential). Nucleus (By similarity). Cytoplasm (By similarity). Note=Following virus entry, the nuclear localization signal (NLS) of the matrix protein participates with Vpr to the nuclear localization of the viral genome. During virus production, the nuclear export activity of the matrix protein counteracts the NLS to maintain the Gag and Gag-Pol polyproteins in the cytoplasm, thereby directing unspliced RNA to the plasma membrane (By similarity).
- SUBCELLULAR LOCATION: Capsid protein p24: Virion (Potential).
- SUBCELLULAR LOCATION: Nucleocapsid protein p7: Virion (Potential).
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by ribosomal frameshifting. Translation results in the formation of the Gag polyprotein most of the time. Ribosomal frameshifting at the gag-pol genes boundary occurs at low frequency and produces the Gag-Pol polyprotein. This strategy of translation probably allows the virus to modulate the quantity of each viral protein. Maintenance of a correct Gag to Gag-Pol ratio is essential for RNA dimerization and viral infectivity.
| Name | Gag polyprotein |
| Isoform ID | P27978-1 |
| Note: Produced by conventional translation. |
| This is the isoform sequence displayed in this entry. |
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| Name | Gag-Pol polyprotein |
| Isoform ID | P27980-1 |
| Note: Produced by -1 ribosomal frameshifting. |
| This isoform is stored in UniProtKB/Swiss-Prot entry P27980. |
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- DOMAIN: Late-budding domains (L domains) are short sequence motifs essential for viral particle release. They can occur individually or in close proximity within structural proteins. They interacts with sorting cellular proteins of the multivesicular body (MVB) pathway. Most of these proteins are class E vacuolar protein sorting factors belonging to ESCRT-I, ESCRT-II or ESCRT-III complexes. p6-gag contains two L domains: a PTAP/PSAP motif, which interacts with the UEV domain of TSG101 and a LXXLF motif which interacts with PDCD6IP/AIP1 (By similarity).
- PTM: Capsid protein p24 is phosphorylated (By similarity).
- PTM: Specific enzymatic cleavages by the viral protease yield mature proteins. The polyprotein is cleaved during and after budding, this process is termed maturation (By similarity).
- MISCELLANEOUS: This is an African green monkey isolate.
- SIMILARITY: Belongs to the primate lentivirus group gag polyprotein family.
- SIMILARITY: Contains 2 CCHC-type zinc fingers.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 521 AA [This is the length of the unprocessed precursor] |
Molecular weight: 58409 Da [This is the MW of the unprocessed precursor] |
CRC64: 1F111BD2F2EDF4F5 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MGAATSALNR RQLDKFEHIR LRPTGKKKYQ IKHLIWAGKE MERFGLHERL LESEEGCKKI
70 80 90 100 110 120
IEVLYPLEPT GSEGLKSLFN LVCVLFCVHK DKEVKDTEEA VAIVRQCCHL VEKERNAERN
130 140 150 160 170 180
TTETSSGQKK NDKGVTVPPG GSQNFPAQQQ GNAWIHVPLS PRTLNAWVKA VEEKKFGAEI
190 200 210 220 230 240
VPMFQALSEG CTPYDINQML NVLGDHQGAL QIVKEIINEE AAQWDIAHPP PAGPLPAGQL
250 260 270 280 290 300
RDPRGSDIAG TTSTVQEQLE WIYTANPRVD VGAIYRRWII LGLQKCVKMY NPVSVLDIRQ
310 320 330 340 350 360
GPKEAFKDYV DRFYKAIRAE QASGEVKQWM TESLLIQNAN PDCKVILKGL GMHPTLEEML
370 380 390 400 410 420
TACQGVGGPS YKAKVMAEMM QNMQSQNMMQ QGGQRGRPRP PVKCYNCGKF GHMQRQCPEP
430 440 450 460 470 480
RKMRCLKCGK PGHLAKDCRG QVNFLGYGRW MGAKPRNFPA ATLGVEPTAP PPPSPYDPAK
490 500 510 520
KLLQQYADKG KQLREQRKKP PAVNPDWTEG YSLNSLFGED Q
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P27978 in FASTA format |
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