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UniProtKB/Swiss-Prot entry P27701


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CD82_HUMAN
Primary accession number P27701
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1992
Sequence was last modified on August 1, 1992 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 76)
Name and origin of the protein
Protein name CD82 antigen
Synonyms Inducible membrane protein R2
C33 antigen
IA4
Metastasis suppressor Kangai-1
Suppressor of tumorigenicity protein 6
Tetraspanin-27
Tspan-27
CD82 antigen
Gene name
Name: CD82
Synonyms: KAI1, SAR2, ST6, TSPAN27
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Peripheral blood lymphocyte;
DOI=10.1002/eji.1830210219; PubMed=1842498 [NCBI, ExPASy, EBI, Israel, Japan]
Gaugitsch H.W., Hofer E., Huber N.E., Schnabl E., Baumruker T.;
"A new superfamily of lymphoid and melanoma cell proteins with extensive homology to Schistosoma mansoni antigen Sm23.";
Eur. J. Immunol. 21:377-383(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1401919 [NCBI, ExPASy, EBI, Israel, Japan]
Imai T., Fukudome K., Takagi S., Nagira M., Furuse M., Fukuhara N., Nishimura M., Hinuma Y., Yoshie O.;
"C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63.";
J. Immunol. 149:2879-2886(1992).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1126/science.7754374; PubMed=7754374 [NCBI, ExPASy, EBI, Israel, Japan]
Dong J.T., Barrett J.C.;
"KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2.";
Science 268:884-886(1995).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.1997.4618; PubMed=9126478 [NCBI, ExPASy, EBI, Israel, Japan]
Dong J.T., Isaacs W.B., Barrett J.C., Isaacs J.T.;
"Genomic organization of the human KAI1 metastasis-suppressor gene.";
Genomics 41:25-32(1997).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[6]
INTERACTION WITH IGSF8.
PubMed=12750295 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang X.A., Lane W.S., Charrin S., Rubinstein E., Liu L.;
"EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells.";
Cancer Res. 63:2665-2674(2003).
[7]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-129, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1021/pr8008012; PubMed=19159218 [NCBI, ExPASy, EBI, Israel, Japan]
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.";
J. Proteome Res. 8:651-661(2009).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X53795; CAA37804.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S48196; AAB23825.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U20770; AAC50133.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U67274; AAC51205.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U67268; AAC51205.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U67269; AAC51205.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U67270; AAC51205.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U67271; AAC51205.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U67272; AAC51205.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U67273; AAC51205.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR542255; CAG47051.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00020446; -.
PIR I38942; A46493.
RefSeq NP_002222.1; -.
UniGene Hs.527778
3D structure databases
ModBase P27701.
Protein-protein interaction databases
IntAct P27701; 1.
PTM databases
PhosphoSite P27701; -.
Organism-specific databases
GeneCards GC11P044544; -.
H-InvDB HIX0017389; -.
HGNC HGNC:6210; CD82.
GenAtlas CD82.
HPA CAB002508; -.
MIM 600623; gene. [NCBI / EBI]
PharmGKB PA142672155; -.
Gene expression databases
ArrayExpress P27701; -.
Bgee P27701; -.
CleanEx HS_CD82; -.
GermOnline ENSG00000085117; Homo sapiens.
Ontologies
GO
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR018499; Tetraspanin.
IPR018503; Tetraspanin_CS.
IPR000301; Tetraspanin_sub.
Graphical view of domain structure.
Pfam PF00335; Tetraspannin; 1.
Pfam graphical view of domain structure.
PRINTS PR00259; TMFOUR.
PROSITE PS00421; TM4_1; 1.
Proteomic databases
PRIDE P27701; -.
Genome annotation databases
Ensembl ENSG00000085117; Homo sapiens. [Contig view]
GeneID 3732; -.
Phylogenomic databases
HOGENOM P27701; -.
HOVERGEN P27701; -.
OMA P27701; QVKCCGW.
Other
NextBio 14607; -.
SOURCE CD82; Homo sapiens.
ProtoNet P27701.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycoprotein; Membrane; Polymorphism; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   267  267     CD82 antigen. PRO_0000219226
TOPO_DOM   1    11  11     Cytoplasmic (Potential). 
TRANSMEM   12    32  21     Potential. 
TOPO_DOM   33    53  21     Extracellular (Potential). 
TRANSMEM   54    72  19     Potential. 
TOPO_DOM   73    83  11     Cytoplasmic (Potential). 
TRANSMEM   84   110  27     Potential. 
TOPO_DOM   111   228  118     Extracellular (Potential). 
TRANSMEM   229   250  22     Potential. 
TOPO_DOM   251   267  17     Cytoplasmic (Potential). 
CARBOHYD   129   129        N-linked (GlcNAc...). 
CARBOHYD   157   157        N-linked (GlcNAc...) (Potential). 
CARBOHYD   198   198        N-linked (GlcNAc...) (Potential). 
VARIANT   241   241  1     I -> V (in dbSNP:rs1139971 [NCBI]). VAR_052326 
CONFLICT   240   241        II -> MV (in Ref. 2; AAB23825). 
Sequence information
Length: 267 AA [This is the length of the unprocessed precursor] Molecular weight: 29626 Da [This is the MW of the unprocessed precursor] CRC64: FC379855BD1CABDE [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGSACIKVTK YFLFLFNLIF FILGAVILGF GVWILADKSS FISVLQTSSS SLRMGAYVFI 

        70         80         90        100        110        120 
GVGAVTMLMG FLGCIGAVNE VRCLLGLYFA FLLLILIAQV TAGALFYFNM GKLKQEMGGI 

       130        140        150        160        170        180 
VTELIRDYNS SREDSLQDAW DYVQAQVKCC GWVSFYNWTD NAELMNRPEV TYPCSCEVKG 

       190        200        210        220        230        240 
EEDNSLSVRK GFCEAPGNRT QSGNHPEDWP VYQEGCMEKV QAWLQENLGI ILGVGVGVAI 

       250        260 
IELLGMVLSI CLCRHVHSED YSKVPKY 

P27701 in FASTA format

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