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UniProtKB/Swiss-Prot entry P27664

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PDE6A_MOUSE
Primary accession number P27664
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1992
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 72)
Name and origin of the protein
Protein name Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Synonyms GMP-PDE alpha
EC 3.1.4.35
Gene name
Name: Pde6a
Synonyms: Mpa, Pdea
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Retina;
DOI=10.1016/0014-5793(91)80095-K; PubMed=1847109 [NCBI, ExPASy, EBI, Israel, Japan]
Baehr W., Champagne M.S., Lee A.K., Pittler S.J.;
"Complete cDNA sequences of mouse rod photoreceptor cGMP phosphodiesterase alpha- and beta-subunits, and identification of beta'-, a putative beta-subunit isozyme produced by alternative splicing of the beta-subunit gene.";
FEBS Lett. 278:107-114(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X60664; CAA43072.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S13030; S13030.
UniGene Mm.391106
3D structure databases
ModBase P27664.
Organism-specific databases
MGI MGI:97524; Pde6a.
Gene expression databases
ArrayExpress P27664; -.
CleanEx MM_PDE6A; -.
GermOnline ENSMUSG00000024575; Mus musculus.
Ontologies
GO
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0047555; Molecular function: 3',5'-cyclic-GMP phosphodiesterase activity (inferred from electronic annotation from EC).
GO:0050896; Biological process: response to stimulus (inferred from electronic annotation from UniProtKB-KW).
GO:0007165; Biological process: signal transduction (inferred from electronic annotation from InterPro).
GO:0007601; Biological process: visual perception (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR003018; GAF.
IPR003607; Met-dep_phosphohydro_HD.
IPR002073; PDEase.
Graphical view of domain structure.
Pfam PF01590; GAF; 2.
PF00233; PDEase_I; 1.
Pfam graphical view of domain structure.
PRINTS PR00387; PDIESTERASE1.
SMART SM00065; GAF; 2.
SM00471; HDc; 1.
SMART graphical view of domain structure.
PROSITE PS00126; PDEASE_I; 1.
BLOCKS P27664.
ProtoNet P27664.
Genome annotation databases
Ensembl ENSMUSG00000024575; Mus musculus. [Contig view]
Phylogenomic databases
HOVERGEN P27664; -.
Other
SOURCE Pde6a; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Cell membrane; cGMP; Hydrolase; Lipoprotein; Membrane; Prenylation; Repeat; Sensory transduction; Vision.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   859  858     Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha. PRO_0000198829
DOMAIN   73   222  150     GAF 1. 
DOMAIN   254   431  178     GAF 2. 
MOD_RES   2     2        N-acetylglycine (By similarity). 
LIPID   856   856        S-farnesyl cysteine (By similarity). 
Sequence information
Length: 859 AA [This is the length of the unprocessed precursor] Molecular weight: 99646 Da [This is the MW of the unprocessed precursor] CRC64: 14E49D60B2E75B6F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGEVTAEEVE KFLDSNIGFA KQYYNLHYRG KVISDLLGAK EAAVDFSNYH DVNSVEESEI 

        70         80         90        100        110        120 
IFDLLRDVQE NLQAEKCTFN VMKKLCFLLR ADRVSLFMYR TRNGIAELAT RLFNVHKDAV 

       130        140        150        160        170        180 
LEDCLVMPDS EIVFPLDMGV VGHVAHSKKI ANVPNTEEDE HFCDFVDNLT EYQTKNILAS 

       190        200        210        220        230        240 
PIMNGKDVVA IIMAVNKIDE PHFTKRDEEI LLKYLNFVNL IMKVFHLSYL HNCETRRGQI 

       250        260        270        280        290        300 
LLWSGSKVFE ELTDIERQFH KALYTVRAFL NCDRYSVGLL DMTKQKEFFD VWPVLMGEAP 

       310        320        330        340        350        360 
AYSGPRTPDG REINFYKVID YILHGKEDIK VIPNPPADHW ALVSGLPPYV AQNGLICNIM 

       370        380        390        400        410        420 
NAPAEDFFEF QKEPLDESGW MIKNVLSMPI VNKKEEIVGV ATFYNRKDGK PFDDMDETLM 

       430        440        450        460        470        480 
ESLTQFLGWS VLNPDTYESM NKLENRKDIF QDIVKYHVKC DNEEIQKILK TREVYGKEPW 

       490        500        510        520        530        540 
ECEEEELAEI LQRELPDAES YEINKFHFSD LPLTELELVK CGIQMYYELR VWDKFHIPQE 

       550        560        570        580        590        600 
ALVRFMYSLS KGYRRITYHN WRHGFNVGQT MFSLLVTGKL KRYFTDLEAL AMVTAAFCHD 

       610        620        630        640        650        660 
IDHRGTNNLY QMKSQNPLAK LHGSSILERH HLEFGKTLLR DESLNIFQNL NRRQHEHAIH 

       670        680        690        700        710        720 
MMDIAIIATD LALYFKKRTM FQKIVDQSKT YESTQEWTQY MMLEQTRKEI VMAMMMTACD 

       730        740        750        760        770        780 
LSAITKPWEV QSKVALLVAA EFWEQGDLER TVLQQNPIPM MDRNKADELP KLQVGFIDFV 

       790        800        810        820        830        840 
CTFVYKEFSR FHEEITPMLD GITNNRKEWK ALADEYEAKM KALEEEKQKQ QAAKQAASGN 

       850 
QPGGNPLQGA PASKSCCIQ
P27664 in FASTA format

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