ID   PLAP_MOUSE              Reviewed;         794 AA.
AC   P27612; Q8C6C4;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 3.
DT   10-JUN-2008, entry version 70.
DE   Phospholipase A-2-activating protein (PLAP).
GN   Name=Plaa; Synonyms=Plap;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-312.
RX   MEDLINE=91271400; PubMed=2052621;
RA   Clark M.A., Oezguer L.E., Conway T.M., Dispoto J., Crooke S.T.,
RA   Bomalaski J.S.;
RT   "Cloning of a phospholipase A2-activating protein.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:5418-5422(1991).
RN   [3]
RP   SEQUENCE REVISION.
RX   MEDLINE=95394363; PubMed=7665086; DOI=10.1016/0378-1119(95)00253-3;
RA   Wang H., Lemasters J.J., Herman B.;
RT   "Cloning of a rat cDNA encoding a protein with high homology to mouse
RT   phospholipase A2-activating protein.";
RL   Gene 161:237-241(1995).
CC   -!- FUNCTION: Plays an important role in the regulation of specific
CC       inflammatory disease processes.
CC   -!- INDUCTION: In smooth muscle and endothelial cells by leukotriene
CC       D4, by tumor necrosis factor in endothelial cells and by uric acid
CC       crystals in macrophages.
CC   -!- SIMILARITY: Belongs to the WD repeat PLAP family.
CC   -!- SIMILARITY: Contains 7 WD repeats.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA39943.1; Type=Miscellaneous discrepancy; Note=Several frameshifts and contaminating sequence;
CC       Sequence=Ref.3; Type=Frameshift; Positions=697;
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DR   EMBL; AK075934; BAC36064.1; -; mRNA.
DR   EMBL; M57958; AAA39943.1; ALT_SEQ; mRNA.
DR   PIR; A40963; A40963.
DR   RefSeq; NP_766283.2; -.
DR   UniGene; Mm.22724; -.
DR   UniGene; Mm.370954; -.
DR   HSSP; P07834; 1NEX.
DR   Ensembl; ENSMUSG00000028577; Mus musculus.
DR   GeneID; 18786; -.
DR   KEGG; mmu:18786; -.
DR   MGI; MGI:104810; Plaa.
DR   HOGENOM; P27612; -.
DR   HOVERGEN; P27612; -.
DR   ArrayExpress; P27612; -.
DR   CleanEx; MM_PLAA; -.
DR   GermOnline; ENSMUSG00000028577; Mus musculus.
DR   GO; GO:0016005; F:phospholipase A2 activator activity; IDA:MGI.
DR   GO; GO:0005515; F:protein binding; IPI:MGI.
DR   GO; GO:0006954; P:inflammatory response; IDA:MGI.
DR   InterPro; IPR015155; PFU.
DR   InterPro; IPR013535; PUL.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like.
DR   InterPro; IPR001680; WD40_repeat.
DR   Gene3D; G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 1.
DR   Pfam; PF09070; PFU; 1.
DR   Pfam; PF08324; PUL; 1.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   ProDom; PD000018; WD40; 2.
DR   SMART; SM00320; WD40; 7.
DR   PROSITE; PS00678; WD_REPEATS_1; FALSE_NEG.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Repeat; WD repeat.
FT   CHAIN         1    794       Phospholipase A-2-activating protein.
FT                                /FTId=PRO_0000051131.
FT   REPEAT       17     56       WD 1.
FT   REPEAT       63    107       WD 2.
FT   REPEAT      110    148       WD 3.
FT   REPEAT      149    188       WD 4.
FT   REPEAT      190    227       WD 5.
FT   REPEAT      229    268       WD 6.
FT   REPEAT      270    307       WD 7.
FT   CONFLICT     60     60       C -> Y (in Ref. 2; AAA39943).
FT   CONFLICT     70     70       C -> Y (in Ref. 2; AAA39943).
FT   CONFLICT    300    301       SE -> AD (in Ref. 3).
FT   CONFLICT    528    528       T -> S (in Ref. 3).
FT   CONFLICT    546    546       A -> T (in Ref. 3).
FT   CONFLICT    593    593       A -> R (in Ref. 3).
SQ   SEQUENCE   794 AA;  87235 MW;  0A8B1CFEC7756017 CRC64;
     MASGASRYRL SCSLPGHELD VRGLVCCLYP PGAFVSVSRD RTTRLWAPDS PNRGFTEMHC
     MSGHSNFVSC VCIIPSSDIY PHGLIATGGN DHNICIFSLD SPMPLYILKG HKDTVCSLSS
     GKFGTLLSGS WDTTAKVWLN DKCMMTLQGH TAAVWAVKIL PEQGLMLTGS ADKTIKLWKA
     GRCERTFLGH EDCVRGLAIL SETEFLSCAN DASIRRWQIT GECLEVYFGH TNYIYSISVF
     PNSKDFVTTA EDRSLRIWKH GECAQTIRLP AQSIWCCCVL ENGDIVVGAS DGIIRVFTES
     EERTASAEEI KAFERELSQA TIDSKTGDLG DINAEQLPGR EHLSEPGTRE GQTRLIRDGE
     RVEAYQWSVS DGRWIKIGDV VGSSGANQQT SGKVLYEGKE FDYVFSIDVN EGGPSYKLPY
     NVSDDPWLVA YNFLQKNDLN PMFLDQVAKF IIDNTKGQTL GLGNTSFSDP FTGGGRYVPG
     TSGPSNTVQT ADPFTGAGRY MPGSAGMDTT MTGVDPFTGN SAYRSAATKT VNIYFPKKEA
     LTFDQANPTQ ILGKLKELNG TAPEEKKLTE DDLVLLEKIL SLICNNSSEK PTAQQLQILW
     KAINWPEDIV FPALDILRLS IKHPNVNENF CNEKGDQFSS HLINLLNPKG KPANQLLALR
     TFCNCFVSQA GQKLMMSQRE SLMSHAIELK SGSNKNIHIA LATLTLNYSV CFHKDHNIEG
     KAQCLSVIST ILEVVQDLEA TFRLLVALGT LISDDSNAIQ LAKSLGVDSQ IKKYVSVSEP
     AKVSECCRLV LHLL
//