[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=VSB-899; DOI=10.1016/0378-1119(91)90311-X; PubMed=1743515 [NCBI, ExPASy, EBI, Israel, Japan] Sasnauskas K., Jomantiene R., Geneviciute E., Januska A., Lebedys J.; "Molecular cloning of the Candida maltosa ADE1 gene."; Gene 107:161-164(1991).
[2]	SEQUENCE REVISION. Sasnauskas K.; Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases.
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=1368674 [NCBI, ExPASy, EBI, Israel, Japan] Kawai S., Hikiji T., Murao S., Takagi M., Yano K.; "Isolation and sequencing of a gene, C-ADE1, and its use for a host-vector system in Candida maltosa with two genetic markers."; Agric. Biol. Chem. 55:59-65(1991).

Comments

CATALYTIC ACTIVITY: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.
PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 4/5 .
SIMILARITY: Belongs to the SAICAR synthetase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M58322; AAA34318.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
D00855; BAA00731.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

JH0489; JH0489.
S55291; S55291.
S55292; S55292.
S55293; S55293.

3D structure databases

HSSP

P27616; 1OBG. [HSSP ENTRY / PDB]

ModBase

P27602.

Ontologies

GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0004639;	Molecular function: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity (inferred from electronic annotation from InterPro).
GO:0006164;	Biological process: purine nucleotide biosynthetic process (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR013816; ATP_grasp_subdomain_2.
IPR001636; SAICAR_synt.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.

PANTHER

PTHR11609; SAICAR_synt; 1.

Pfam

PF01259; SAICAR_synt; 1.
Pfam graphical view of domain structure.

ProDom

PD003043; SAICAR_synt; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR00081; purC; 1.

PROSITE

PS01057; SAICAR_SYNTHETASE_1; 1.
PS01058; SAICAR_SYNTHETASE_2; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Ligase; Purine biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 291`	`291`		`Phosphoribosylaminoimidazole-succinocarboxamide synthase.`	`PRO_0000100924`

Sequence information

Length: 291 AA [This is the length of the unprocessed precursor]

Molecular weight: 32941 Da [This is the MW of the unprocessed precursor]

CRC64: A1DF09E65E9A9117 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTSTNLEGTF PLIAKGKVRD IYQVDDNTLL FVATDRISAY DVIMSNGIPN KGKILTKLSE 

        70         80         90        100        110        120 
FWFDFLPIEN HLIKGDIFQK YPQLEPYRNQ LEGRSLLVRK LKLIPLEVIV RGYITGSGWK 

       130        140        150        160        170        180 
EYQKSKTVHG IPIGDVVESQ QITPIFTPST KAEQGEHDEN ITKEQADKIV GKELCDRIEK 

       190        200        210        220        230        240 
IAIDLYTKAR DYAATKGIII ADTKFEFGLD GDNIVLVDEV LTPDSSRFWN AAKYEVGKSQ 

       250        260        270        280        290 
DSYDKQFLRD WLTSNGVAGK DGVAMPEDIV TETKSKYVEA YENLTGDKWQ E

P27602 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools