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UniProtKB/Swiss-Prot entry P27543

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MTLD_ENTFA
Primary accession number P27543
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1992
Sequence was last modified on April 23, 2003 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 57)
Name and origin of the protein
Protein name Mannitol-1-phosphate 5-dehydrogenase
Synonym EC 1.1.1.17
Gene name
Name: mtlD
OrderedLocusNames: EF_0413
From
Enterococcus faecalis (Streptococcus faecalis) [TaxID: 1351] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Enterococcaceae; Enterococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1904856 [NCBI, ExPASy, EBI, Israel, Japan]
Fischer R., von Strandmann R.P., Hengstenberg W.;
"Mannitol-specific phosphoenolpyruvate-dependent phosphotransferase system of Enterococcus faecalis: molecular cloning and nucleotide sequences of the enzyme IIIMtl gene and the mannitol-1-phosphate dehydrogenase gene, expression in Escherichia coli, and comparison of the gene products with similar enzymes.";
J. Bacteriol. 173:3709-3715(1991).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=V583 / ATCC 700802;
DOI=10.1126/science.1080613; PubMed=12663927 [NCBI, ExPASy, EBI, Israel, Japan]
Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C., Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M., Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
"Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis.";
Science 299:2071-2074(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M38386; AAA24780.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE016830; AAO80272.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C39435; C39435.
RefSeq NP_814201.1; -.
3D structure databases
ModBase P27543.
Enzyme and pathway databases
BioCyc EFAE226185:EF_0413-MON; -.
Ontologies
GO
GO:0008926; Molecular function: mannitol-1-phosphate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00196; -; 1.
PBIL [Tree]
InterPro IPR013328; DHase_multihelical.
IPR013118; Mannitol_DHase_C.
IPR000669; Mannitol_DHase_core.
IPR013131; Mannitol_DHase_N.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
Pfam PF01232; Mannitol_dh; 1.
PF08125; Mannitol_dh_C; 1.
Pfam graphical view of domain structure.
PRINTS PR00084; MTLDHDRGNASE.
PROSITE PS00974; MANNITOL_DHGENASE; 1.
BLOCKS P27543.
Genome annotation databases
GeneID 1199330; -.
GenomeReviews AE016830_GR; EF_0413.
KEGG efa:EF0413; -.
NMPDR fig|226185.1.peg.387; -.
TIGR EF_0413; -.
Phylogenomic databases
HOGENOM P27543; -.
Other
ProtoNet P27543.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   384  384     Mannitol-1-phosphate 5-dehydrogenase. PRO_0000170706
NP_BIND   3    14  12     NAD (By similarity). 
CONFLICT   23    28        NGFHIT -> TGFILP (in Ref. 1; AAA24780). 
CONFLICT   34    37        ETII -> GNHH (in Ref. 1; AAA24780). 
CONFLICT   115   115        K -> NG (in Ref. 1; AAA24780). 
CONFLICT   138   146        KYLKNPAYA -> IIFEKPSLS (in Ref. 1; AAA24780). 
CONFLICT   167   167        E -> K (in Ref. 1; AAA24780). 
CONFLICT   198   202        HYVAD -> ITCR (in Ref. 1; AAA24780). 
CONFLICT   215   216        NT -> TS (in Ref. 1; AAA24780). 
CONFLICT   277   277        Q -> N (in Ref. 1; AAA24780). 
CONFLICT   320   323        PHLL -> AAFI (in Ref. 1; AAA24780). 
CONFLICT   356   384        IAEVTGIEDPETVKNIKQNVERYARPQVA -> DR (in Ref. 1; AAA24780). 
Sequence information
Length: 384 AA [This is the length of the unprocessed precursor] Molecular weight: 43099 Da [This is the MW of the unprocessed precursor] CRC64: CE51664A668BC7CD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNAVHFGAGN IGRGFIGEIL AKNGFHITFV DVNETIIQAL KERKSYTIEL ADASHQQINV 

        70         80         90        100        110        120 
ENVTGLNNMT EPEKVVEAIA EADLVTTAIG PNILPRIAEL IAQGIDARAE ANCQKPLDII 

       130        140        150        160        170        180 
ACENMIGGST FLAEEVAKYL KNPAYAEQWI GFPDAAVDRI VPLQKHEDPL FVQVEPFCEW 

       190        200        210        220        230        240 
VIDDTNRKAK EIQLEGVHYV ADLEPYIERK LFSVNTGHAT VAYTGALLGY QTIDEAMQDA 

       250        260        270        280        290        300 
LVVAQLKSVL QETGKLLVAK WNFDEQEHAA YIEKIIQRFQ NKYISDAITR VARTPIRKLG 

       310        320        330        340        350        360 
AQERFIRPIR ELQERNLVSP HLLAMIGIVF NYHDPEDEQS RQLQEMLDQE SVDTVIAEVT 

       370        380 
GIEDPETVKN IKQNVERYAR PQVA
P27543 in FASTA format

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