NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=W70;
PubMed=1551851 [NCBI, ExPASy, EBI, Israel, Japan]
Azakami H., Sugino H., Murooka Y.;
"Cloning and nucleotide sequence of a negative regulator gene for Klebsiella aerogenes arylsulfatase synthesis and identification of the gene as folA.";
J. Bacteriol. 174:2344-2351(1992).

Comments

FUNCTION: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity).
CATALYTIC ACTIVITY: P₁,P⁴-bis(5'-adenosyl) tetraphosphate + H₂O = 2 ADP.
SIMILARITY: Belongs to the Ap4A hydrolase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

D10358; BAA01188.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

P27510; 1-245.

ModBase

P27510.

Ontologies

GO:0008803;	Molecular function: bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00199; -; 1.
PBIL [Tree]

InterPro

IPR004617; ApaH.
IPR004843; M-pesterase.
Graphical view of domain structure.

Pfam

PF00149; Metallophos; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000903; B5n-ttraPtase_sm; 1.

TIGR00668; apaH; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Hydrolase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 259`	`>259`	`Bis(5'-nucleosyl)-tetraphosphatase, symmetrical.`	`PRO_0000197994`
`NON_TER`	`1 1`

Sequence information

Length: 259 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 29115 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 8755312AAC7AF7CD [This is a checksum on the sequence]

        10         20         30         40         50         60 
EFDPRRDTLW LTGDLVARGP GSLEVLRYVK SLGDTVRLVL GNHDLHLLAV FAGISRNKPK 

        70         80         90        100        110        120 
DRLKPLLEAP DADELLNWLR RQPLLQVDEE KKLVMAHAGI TPQWDLETAQ QCARDVEAVL 

       130        140        150        160        170        180 
SSDSYPFFLD AMYGDMPNHW SNELSGLARL RFISNAFTRM RYCFPNGQLD MYSKEAPEDA 

       190        200        210        220        230        240 
PAPLKPWFAI PGPVSNAYSI AFGHWASLEG RGTPEGIYAL DTGCCWGGEL TCLRWEDKQY 

       250 
FTQPSNRQKS LDEGEAVAS

P27510 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools