ID   ORF2A_BBMV              Reviewed;         810 AA.
AC   P27462;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-NOV-2008, entry version 41.
DE   RecName: Full=RNA-directed RNA polymerase 2A;
DE            Short=protein 2A;
DE            EC=2.7.7.48;
GN   Name=RNA2; ORFNames=ORF2a;
OS   Broad bean mottle virus.
OC   Viruses; ssRNA positive-strand viruses, no DNA stage; Bromoviridae;
OC   Bromovirus.
OX   NCBI_TaxID=12301;
OH   NCBI_TaxID=3906; Vicia faba (Broad bean).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   MEDLINE=92188542; PubMed=1546462; DOI=10.1016/0042-6822(92)90470-A;
RA   Romero J., Dzianott A.M., Bujarski J.J.;
RT   "The nucleotide sequence and genome organization of the RNA2 and RNA3
RT   segments in broad bean mottle virus.";
RL   Virology 187:671-681(1992).
CC   -!- FUNCTION: RNA-directed RNA polymerase.
CC   -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
CC       + RNA(n+1).
CC   -!- MISCELLANEOUS: The virus has a tripartite genome (RNA1, RNA2 and
CC       RNA3) and an encapsidated subgenomic RNA (RNA4) from which the
CC       coat protein is expressed. Virions are icosahedral, not enveloped,
CC       with 32 capsomers per nucleocapsid.
CC   -!- SIMILARITY: Belongs to the cucumoviruses/bromoviruses 2A family.
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DR   EMBL; M64713; AAA42741.1; -; Genomic_RNA.
DR   PIR; A42453; P2WMBB.
DR   RefSeq; NP_658999.1; -.
DR   GeneID; 962139; -.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-directed RNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:InterPro.
DR   InterPro; IPR007610; DUF585.
DR   InterPro; IPR001788; RNA-dep_RNA_pol_vir-typ.
DR   Pfam; PF04522; DUF585; 1.
DR   Pfam; PF00978; RdRP_2; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase; RNA-directed RNA polymerase; Transferase.
FT   CHAIN         1    810       RNA-directed RNA polymerase 2A.
FT                                /FTId=PRO_0000083268.
SQ   SEQUENCE   810 AA;  92993 MW;  BDB1A5EB27D532AE CRC64;
     MSKFVAADEY IVPSFQWLLG PTSSQVESFD SSVAGWIKRY EDESKRPEST VDGSCESFVL
     AVKPVMIGGQ CEPAYDQAKW AETCLNVTNL ASGLTGVRLI PLPEMARMIY LDEEDSFVDE
     SEVDDWYPED TSDGFEYLSA DGSDYHQNSE PEEEVLDKSN GTLESEEARH ETDVKSICSF
     RDIPVETTMG HRYLALSEEF ASIEVDYQVS SIVTPLNKGS IYMTLDVHEE THPKSGIQDK
     ASIERLEAAG HNALKTHAYF DDSYYEGFEE SADFSSDFQR LKIKQSHVDW YKDPDKFFEP
     VLNFGASSRR VGSQKTVLTA LKKRNADVPE LSDVVDATEV PICLRQSYLN IYGADCLFES
     FNIMAKGLDY HKRWKSHKEL QGVTLLCETN LQRYQHMIKS DVKPTVTDTL HVERDVPATI
     TFHGKGVTSC FSPFFTACFE KFSLALRESI YVPIGKISSL ELKSKALNNK FFLEADLSKF
     DKSQGELHLE FQRLILINLG FPVPLTNWWC DFHRSILSRW TLRPGVSIPL LSKTNRGCFH
     LLWEHFSDNA MMAYCFDMST AELAMFSGDD SLVICGSKPE FDPGVFQSLF NMEVKVMDPS
     LPYICSKFLL ESEFGDVFSV PDPMREIQRL QKRKIPKDVQ VLRADFDSFC DRMKFLDRLS
     ELSLSVLCRL TALKYCKPGI EGDVRAWLSG FAYYRENFLR YSECYVTDGI HCYRRVDPMS
     RFKPIDKFQR SDKEWFHDWR NNEFPKKPID KMARMFGAYK GPVNNDRVER KAKYKVNAAM
     HDPFALAYER RYVQELELKN DKGNCSVLRE
//