[1]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=Rio Lancetilla; PubMed=1707152 [NCBI, ExPASy, EBI, Israel, Japan] Hannig G., Ottilie S., Schartl M.; "Conservation of structure and expression of the c-yes and fyn genes in lower vertebrates."; Oncogene 6:361-369(1991).

Comments

FUNCTION: Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension (By similarity).
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
COFACTOR: Manganese.
ENZYME REGULATION: Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site (By similarity).
SUBUNIT: Associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
SIMILARITY: Contains 1 protein kinase domain.
SIMILARITY: Contains 1 SH2 domain.
SIMILARITY: Contains 1 SH3 domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X54971; CAA38715.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

I51592; I51592.

3D structure databases

HSSP

P06241; 1G83. [HSSP ENTRY / SWISS-3DIMAGE / PDB]

ModBase

P27446.

Ontologies

GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0030145;	Molecular function: manganese ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004715;	Molecular function: non-membrane spanning protein tyrosine kinase activity (inferred from electronic annotation from EC).
GO:0005515;	Molecular function: protein binding (inferred from electronic annotation from InterPro).
GO:0007275;	Biological process: multicellular organismal development (inferred from electronic annotation from UniProtKB-KW).
GO:0006468;	Biological process: protein amino acid phosphorylation (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR000980; SH2.
IPR001452; SH3.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.505.10; SH2; 1.

Pfam

PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
Pfam graphical view of domain structure.

PRINTS

PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.

ProDom

PD000001; Prot_kinase; 1.
PD000093; SH2; 1.
PD000066; SH3; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
SMART graphical view of domain structure.

PROSITE

PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PROSITE graphical view of domain structure (profiles).

Phylogenomic databases

HOVERGEN

P27446; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Developmental protein; Kinase; Lipoprotein; Manganese; Metal-binding; Myristate; Nucleotide-binding; Palmitate; Phosphoprotein; Proto-oncogene; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 537`	`536`	`Proto-oncogene tyrosine-protein kinase FYN.`	`PRO_0000088102`
`DOMAIN`	`82 143`	`62`	`SH3.`
`DOMAIN`	`149 246`	`98`	`SH2.`
`DOMAIN`	`271 524`	`254`	`Protein kinase.`
`NP_BIND`	`277 285`	`9`	`ATP (By similarity).`
`ACT_SITE`	`390 390`		`Proton acceptor (By similarity).`
`BINDING`	`299 299`		`ATP (By similarity).`
`MOD_RES`	`12 12`		`Phosphothreonine; by PKC (By similarity).`
`MOD_RES`	`420 420`		`Phosphotyrosine; by autocatalysis (By similarity).`
`MOD_RES`	`531 531`		`Phosphotyrosine (By similarity).`
`LIPID`	`2 2`		`N-myristoyl glycine (By similarity).`
`LIPID`	`3 3`		`S-palmitoyl cysteine (By similarity).`
`LIPID`	`6 6`		`S-palmitoyl cysteine (By similarity).`

Sequence information

Length: 537 AA [This is the length of the unprocessed precursor]

Molecular weight: 60447 Da [This is the MW of the unprocessed precursor]

CRC64: 6AC5486B13C3876B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGCVQCKDKE ATKLTDDRDA SISQGAGYRY GADPTPQHYP SFGVTAIPNY NNFHAPVGQG 

        70         80         90        100        110        120 
VTVFGGVNTS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFRKGERFQ ILNSTEGDWW 

       130        140        150        160        170        180 
DARSLTTGGS GYIPSNYVAP VDSIQAEDWY FGKLGRKDAE RQLLSTGNPR GTYLIRESET 

       190        200        210        220        230        240 
TKGAFSLSIR DWDDEKGDHV KHYKIRKLDS GGYYITTRAQ FDTLQQLVQH YSDRAAGLCC 

       250        260        270        280        290        300 
RLVVPCHKGM PRLADLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGTTKVAVKT 

       310        320        330        340        350        360 
LKPGTMSPES FLEEAQIMKK LRHDKLVQLY AVVSEEPIYI VTEYMSKGSL LDFLKDGEGR 

       370        380        390        400        410        420 
ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGD NLVCKIADFG LARLIEDNEY 

       430        440        450        460        470        480 
TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEQVE 

       490        500        510        520        530 
RGYRMPCPQD CPASLHELML QCWKKDPEER PTFEYLQAFL EDYFTATEPQ YQPGDNL

P27446 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools