[1]
|
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=T-cell;
DOI=10.1016/0167-4781(91)90136-A; PubMed=2015305 [NCBI, ExPASy, EBI, Israel, Japan]
Nielsen P.J.;
"Primary structure of a human protein kinase regulator protein.";
Biochim. Biophys. Acta 1088:425-428(1991).
|
[2]
|
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Keratinocyte;
DOI=10.1006/jmbi.1993.1346; PubMed=8515476 [NCBI, ExPASy, EBI, Israel, Japan]
Leffers H.,
Madsen P.,
Rasmussen H.H.,
Honore B.,
Andersen A.H.,
Walbum E.,
Vandekerckhove J.,
Celis J.E.;
"Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway.";
J. Mol. Biol. 231:982-998(1993).
|
[3]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N.,
Chen X.,
Rolfs A.,
Halleck A.,
Hines L.,
Eisenstein S.,
Koundinya M.,
Raphael J.,
Moreira D.,
Kelley T.,
LaBaer J.,
Lin Y.,
Phelan M.,
Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
|
[4]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Eye, Skin, and Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
|
[5]
|
PROTEIN SEQUENCE OF 1-18.
TISSUE=Platelet;
DOI=10.1038/nbt810; PubMed=12665801 [NCBI, ExPASy, EBI, Israel, Japan]
Gevaert K.,
Goethals M.,
Martens L.,
Van Damme J.,
Staes A.,
Thomas G.R.,
Vandekerckhove J.;
"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.";
Nat. Biotechnol. 21:566-569(2003).
|
[6]
|
PROTEIN SEQUENCE OF 1-9; 28-49; 61-68; 104-115; 139-167 AND 213-222, ACETYLATION AT MET-1, AND MASS SPECTROMETRY.
TISSUE=B-cell lymphoma, and Hepatoma;
Bienvenut W.V.,
Dhillon A.S.,
Kolch W.;
Submitted (FEB-2008) to UniProtKB.
|
[7]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 73-245.
TISSUE=Brain;
Yu W.,
Gibbs R.A.;
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
|
[8]
|
PHOSPHORYLATION AT SER-232, AND MASS SPECTROMETRY.
DOI=10.1074/jbc.272.46.28882; PubMed=9360956 [NCBI, ExPASy, EBI, Israel, Japan]
Dubois T.,
Rommel C.,
Howell S.,
Steinhussen U.,
Soneji Y.,
Morrice N.,
Moelling K.,
Aitken A.;
"14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction.";
J. Biol. Chem. 272:28882-28888(1997).
|
[9]
|
TISSUE SPECIFICITY.
DOI=10.1046/j.1471-4159.2000.0752511.x; PubMed=11080204 [NCBI, ExPASy, EBI, Israel, Japan]
Malaspina A.,
Kaushik N.,
de Belleroche J.;
"A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord.";
J. Neurochem. 75:2511-2520(2000).
|
[10]
|
INTERACTION WITH CDKN1B.
DOI=10.1074/jbc.M203668200; PubMed=12042314 [NCBI, ExPASy, EBI, Israel, Japan]
Fujita N.,
Sato S.,
Katayama K.,
Tsuruo T.;
"Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.";
J. Biol. Chem. 277:28706-28713(2002).
|
[11]
|
INTERACTION WITH SSH1.
DOI=10.1083/jcb.200401136; PubMed=15159416 [NCBI, ExPASy, EBI, Israel, Japan]
Nagata-Ohashi K.,
Ohta Y.,
Goto K.,
Chiba S.,
Mori R.,
Nishita M.,
Ohashi K.,
Kousaka K.,
Iwamatsu A.,
Niwa R.,
Uemura T.,
Mizuno K.;
"A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia.";
J. Cell Biol. 165:465-471(2004).
|
[12]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, AND MASS SPECTROMETRY.
DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan]
Daub H.,
Olsen J.V.,
Bairlein M.,
Gnad F.,
Oppermann F.S.,
Korner R.,
Greff Z.,
Keri G.,
Stemmann O.,
Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
|
[13]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N.,
Zhou C.,
Villen J.,
Beausoleil S.A.,
Bakalarski C.E.,
Elledge S.J.,
Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
|
[14]
|
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J.,
Superti-Furga G.,
Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
|
[15]
|
X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).
DOI=10.1038/376188a0; PubMed=7603573 [NCBI, ExPASy, EBI, Israel, Japan]
Xiao B.,
Smerdon S.J.,
Jones D.H.,
Dodson G.G.,
Soneji Y.,
Aitken A.,
Gamblin S.J.;
"Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways.";
Nature 376:188-191(1995).
|
[16]
|
X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 1-234, MASS SPECTROMETRY, INTERACTION WITH PHOSPHOSERINE MOTIFS, AND SUBUNIT.
DOI=10.1073/pnas.0605779103; PubMed=17085597 [NCBI, ExPASy, EBI, Israel, Japan]
Yang X.,
Lee W.H.,
Sobott F.,
Papagrigoriou E.,
Robinson C.V.,
Grossmann J.G.,
Sundstroem M.,
Doyle D.A.,
Elkins J.M.;
"Structural basis for protein-protein interactions in the 14-3-3 protein family.";
Proc. Natl. Acad. Sci. U.S.A. 103:17237-17242(2006).
|
|
- FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
- SUBUNIT: Homodimer. Interacts with PCTK1 (By similarity). Interacts with SSH1. Interacts with CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm.
- INTERACTION:
Q9P0K1-1:ADAM22; NbExp=2; IntAct=EBI-359854, EBI-1567258;
Q9P0K1-3:ADAM22; NbExp=1; IntAct=EBI-359854, EBI-1567267;
P49407:ARRB1; NbExp=1; IntAct=EBI-359854, EBI-743313;
P32121:ARRB2; NbExp=1; IntAct=EBI-359854, EBI-714559;
P15056:BRAF; NbExp=1; IntAct=EBI-359854, EBI-365980;
Q6ICG6:C22orf9; NbExp=1; IntAct=EBI-359854, EBI-1053969;
Q9NZT1:CALML5; NbExp=1; IntAct=EBI-359854, EBI-1051681;
Q8IUF1:CBWD2; NbExp=1; IntAct=EBI-359854, EBI-359159;
P26196:DDX6; NbExp=1; IntAct=EBI-359854, EBI-351257;
Q7Z401:DENND4A; NbExp=1; IntAct=EBI-359854, EBI-1046479;
Q96F86:EDC3; NbExp=1; IntAct=EBI-359854, EBI-997311;
Q32P44:EML3; NbExp=1; IntAct=EBI-359854, EBI-1046713;
O43491:EPB41L2; NbExp=1; IntAct=EBI-359854, EBI-1052044;
Q9Y2J2:EPB41L3; NbExp=1; IntAct=EBI-359854, EBI-310986;
P23945:FSHR; NbExp=3; IntAct=EBI-359854, EBI-848239;
O75494:FUSIP1; NbExp=1; IntAct=EBI-359854, EBI-353655;
Q9Y4H2:IRS2; NbExp=1; IntAct=EBI-359854, EBI-1049582;
Q02241:KIF23; NbExp=1; IntAct=EBI-359854, EBI-306852;
P33176:KIF5B; NbExp=1; IntAct=EBI-359854, EBI-355878;
O60282:KIF5C; NbExp=1; IntAct=EBI-359854, EBI-717170;
Q9H0B6:KLC2; NbExp=1; IntAct=EBI-359854, EBI-726994;
Q9NSK0:KLC4; NbExp=1; IntAct=EBI-359854, EBI-949319;
Q6PKG0:LARP1; NbExp=1; IntAct=EBI-359854, EBI-1052114;
Q9Y383:LUC7L2; NbExp=1; IntAct=EBI-359854, EBI-352851;
P61326:MAGOH; NbExp=1; IntAct=EBI-359854, EBI-299134;
P27448:MARK3; NbExp=1; IntAct=EBI-359854, EBI-707595;
Q6WCQ1:MPRIP; NbExp=1; IntAct=EBI-359854, EBI-1022605;
O96013:PAK4; NbExp=1; IntAct=EBI-359854, EBI-713738;
Q9NQU5:PAK6; NbExp=1; IntAct=EBI-359854, EBI-1053685;
O94921:PFTK1; NbExp=3; IntAct=EBI-359854, EBI-1043945;
Q9UBF8:PI4KB; NbExp=1; IntAct=EBI-359854, EBI-1053214;
Q96T60:PNKP; NbExp=1; IntAct=EBI-359854, EBI-1045072;
Q86W92:PPFIBP1; NbExp=1; IntAct=EBI-359854, EBI-1045582;
Q15276:RABEP1; NbExp=1; IntAct=EBI-359854, EBI-447043;
P04049:RAF1; NbExp=1; IntAct=EBI-359854, EBI-365996;
Q9P0K7:RAI14; NbExp=1; IntAct=EBI-359854, EBI-1023749;
Q8IV61:RASGRP3; NbExp=1; IntAct=EBI-359854, EBI-1047876;
Q5PRF9:SAMD4B; NbExp=1; IntAct=EBI-359854, EBI-1047489;
Q07955:SFRS1; NbExp=1; IntAct=EBI-359854, EBI-398920;
P84103:SFRS3; NbExp=1; IntAct=EBI-359854, EBI-372557;
Q13247:SFRS6; NbExp=1; IntAct=EBI-359854, EBI-745230;
Q9P0V3:SH3BP4; NbExp=1; IntAct=EBI-359854, EBI-1049513;
Q08AE8:SPIRE1; NbExp=1; IntAct=EBI-359854, EBI-1055655;
Q4FZB7:SUV420H1; NbExp=1; IntAct=EBI-359854, EBI-1047962;
Q9UDY2:TJP2; NbExp=1; IntAct=EBI-359854, EBI-1042602;
P49815:TSC2; NbExp=1; IntAct=EBI-359854, EBI-396587;
P40818:USP8; NbExp=1; IntAct=EBI-359854, EBI-1050865;
- SUBCELLULAR LOCATION: Cytoplasm. Note=In neurons, axonally transported to the nerve terminals.
- TISSUE SPECIFICITY: Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
- SIMILARITY: Belongs to the 14-3-3 family.
|